Histone variants

Histone variants have emerged as key players in regulating chromatin structure and dynamics and represent a key epigenetic code. This EMBO Workshop will be the second in the series and will cover broad aspects of the biology and structural variations of histones and their impact in cellular processes. Topics will include:
structure of histone variants and their mode of incorporation into chromatin
genome organization
responses to the environment
reprogramming and stem cells
gametogenesis and reproduction
At this second EMBO Workshop, we will incorporate a novel aspect of a perspective in systems biology, in order to strengthen this important emerging topic. close
Epigenetic mechanisms are key for gene regulation and regulate cell plasticity, cell differentiation and development. In the recent years, epigenetics has become a main and extremely productive field in the life sciences. In general terms, epigenetic mechanisms involve
(i) the packing of the DNA,
(ii) the dynamics of eu- and hetero- chromatin compartments and chromatin components as well as
(iii) covalent modifications of DNA and histones.
The building block of the chromatin is the nucleosome, which is composed of an octamer of two copies of each of the core histones wrapped by DNA. Apart from the major core histones, whose synthesis and incorporation into chromatin is linked to the S phase of the cell cycle, histone ʻvariantsʼ are synthesized and incorporated into chromatin independently of DNA replication. These ʻreplacementʼ histones confer distinct properties to nucleosomes, and appear to be involved in important epigenetic processes such as X-inactivation. Recent progress has made clear that histone variants have a key role in regulating chromatin structure regulating development, reprogramming of germ cells and parasite infectiousness. The EMBO Workshop will focus on the structural and functional impacts of variations in histone sequence. Specialists of chromatin structure and transcription will meet with developmental biologists and physiologists to share their common interest on histone variants in yeast, plants and animals.
+ show speakers and program
KEYNOTE SPEAKER

Susan Gasser
Friedrich Miescher Institute for Biomedical Research (FMI)
CH
website

SPEAKERS

Karolin Luger
Colorado State University
USA
Genevieve Almouzni
Institut Curie
France
Kami Ahmad
Harvard Medical School
USA
Benjamin Loppin
Universite Claude Bernard
France
Saadi Khochbin
Institut Albert Bonniot Grenoble
France
Bing Zhu
Chinese Academy of Medical Sciences
China
Steve Henikoff
Fred Hutchinson Cancer Center
USA
Hitoshi Kurumizaka
Waseda University
Japan
Dan Zilberman
UC Berkeley
USA
Robin Allshire
Welcome Trust Centre for Cell Biology Edinburgh
UK
Gary Karpen
UC Berkeley
USA
Ben Black
University of Pennsylvania
USA
David Tremethick
Australian National University
Australia
Arthur Skoultchi
Albert Einstein College of Medicine NY
USA
Robert Schneider
IGBMC
France
Jessica Tyler
MD Anderson
USA
Shiv Grewal
National Cancer Institute
USA

2 Jun - 4 Jun 2012
Strasbourg
France
meeting website