Mechanisms of neuronal remodelling

During neural development, exuberant connections are first formed and later eliminated by regressive changes in neuronal morphology, which establish the mature pattern of dendrites and axons. Such neuronal remodelling is widespread across the animal kingdom, from insects to humans, and forms an essential part of nervous system wiring. As excessive or reduced neuronal remodelling might contribute to neurological diseases, remodelling is a Janus-faced process with physiological, as well as pathological roles - akin to programmed cell death. Understanding how neurites are remodeled during development should provide a broader insight into the process of axon destruction during disease and following injury. This EMBO Workshop will focus on the cellular and molecular mechanisms underlying neuronal remodelling across different animal models and their relation to the proper function of the nervous system.
This EMBO Workshop is cofunded by the Israeli Science Foundation.
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In this EMBO Workshop, we will focus on important unresolved questions on the mechanisms of neuronal remodelling.
These will include:
What cellular and molecular programs mediate neuronal remodelling? Are they conserved between different forms of remodelling?
What are the similarities to other regressive phenomena, such as apoptosis, autophagy and injury induced degeneration? Which roles do glia or immune cells play in remodelling?
What is the role of neuronal remodelling in brain plasticity, learning and memory?
Are there "diseases of remodelling"? What is the role of remodelling in neuro-psychiatric disorders, such as schizophrenia or autism?
+ show speakers and program
Bareyre, Florence
Ludwig-Maximilians University of Munich
Germany
website
Cheng, Hwai-Jong
University of California Davis
USA
website
Collins, Catherine
University of Michigan
USA
wesbite
Courchesne, Eric
University of California San Diego
USA website
Davis, Graeme
University of California San Francisco
USA
website
Dura, Jean-Maurice
The National Centre for Scientific Research (CNRS), Montpellier
France
website
Fainzilber, Mike
Weizmann Institute
Israel
website
Freeman, Marc
University of Massachusetts and HHMI
USA
website
Godinho, Leanne
Technical University Munich
Germany
website
Götz, Magdalena
Ludwig-Maximilians University of Munich
Germany
website
Holt, Christine
University of Cambridge
UK
website
Jan, Yuh-Nung
University of California San Francisco and HHMI
USA
website
Kolodkin, Alex
Johns Hopkins University and HHMI
USA
website
Luo, Liqun
Stanford University and HHMI
USA
website
Miller, Freda
University of Toronto
Canada
website
Misgeld, Thomas
Technical University Munich
Germany
website
Mizrahi, Adi
Hebrew University
Israel
website
O’Leary, Dennis
Salk Institute
USA
website
Podbilewicz, Benjamin
Technion
Israel
website
Rico , Beatriz
Institute for Neuroscience, Alicante
Spain
website
Rolls, Melissa
Penn State University
USA
website
Segal, Rosalind
Harvard University
USA
website
Sagasti, Alvaro
University of California Los Angeles
USA
website
Schmucker, Dietmar
VIB Vesalius Research Center
Belgium
website
Schuldiner, Oren
Weizmann Institute
Israel
website
Schwartz, Michal
Weizmann Institute
Israel
website
Stevens, Beth
Harvard University
USA
website
Tessier-Lavigne, Marc
Rockefeller University
USA
website
Wong, Rachel
University of Washington
USA
website
Yaron, Avraham
Weizmann Institute
Israel
website

22 Mar - 26 Mar 2014
Kibbutz Ein-Gedi,
Israel
meeting website