Lymphocyte signalling

A remarkable body of knowledge has been accumulated in the last decade on the signalling machinery responsible for coupling antigen receptors both to mediators of rapid reponses and to transcriptional effectors. Thus equipped, not only have we been able to study lymphocyte development, activation and differentiation using sophisticated mouse models, but we are finally beginning to translate these findings to the dissection of human lymphocyte responses with the same precision as with animal models. A quantum leap has been achieved with the development of potent imaging and bioinformatic tools that now make it possible to use what we learned to study the immune response in vivo in the complex context of the lymphoid organs, both under homeostatic conditions and during infection, dissecting the precise contribution of each cell type to the global output. Moreover we are finally beginning to glean the results of the studies on signalling by antigen receptors in the area of translational medicine, with the development of drugs that specifically target these signalling pathways for the treatment of immune-related diseases. The principle objective of this EMBO Conference is to provide a forum to critically assess recent progress in this rapidly moving area of signalling in the immune system. close
Main topics:
TCR signalling: from structure to signal initiation
Signaling downstream of antigen receptors: from single molecules to high throughput approaches
Regulation of immune synapse assembly
Metabolic control of the immune response
Signalling pathways that regulate effector and memory cell differentiation
Signalling pathways critical for immune cell development
Regulation of lymphocyte activation and fate by other immune cells
Lymphocyte activation and differentiation during the course of infection
Targeting antigen receptor signalling for immunotherapy
+ show speakers and program

SATURDAY 17 MAY

14:00-18:30
Registration
18:30
Welcome cocktail
19:00
Dinner

20:45-21:00
Welcome remarks

21:00-22:00
Keynote address by Ron Germain, USA

SUNDAY 18 MAY


Session 1: TCR signalling: from structure to signal initiation
9:00-9:30
Chris Garcia, USA
9:30-10:00
Michael Dustin, UK
10:00-10:30
Susan Pierce, USA
10:30-11:00
Balbino Alarcon, Spain
11:00-11:15
1 selected short talk
11:15-11:45
Coffee break

Session 2: Signalling downstream of antigen receptors: from single molecules to high throughput approaches (I)
11:45-12:15
Larry Samelson, USA
12:15-12:45
Arthur Weiss, USA
12:45-13:15
2 selected short talks
13:15
Lunch
15:00-18:45
Poster session (with poster competition and drinks)
19:00
Dinner

Session 3: Signalling downstream of antigen receptors: from single molecules to high throughput approaches (II)
20:30-21:00
Oreste Acuto, UK
21:00-21:30
Rose Zamoyska, UK
21:30-22:00
2 selected short talks

MONDAY 19 MAY


Session 4: Regulation of immune synapse assembly
9:00-9:30
Katarina Gaus, Australia
9:30-10:00
Christopher Wuelfing, UK
10:00-10:15
Cosima T Baldari, Italy
10:15-10:30
Claire Hivroz, France
10:30-11:00
2 selected short talks
11:00-11:30
Coffee break
11:30-12:00
Facundo Batista, UK
12:00-12:30
Francisco Sanchez-Madrid, Spain
12:30
Lunch

Session 5: Metabolic control of the immune response
14:00-14:30
Jonathan Powell, USA
14:30-15:00
Doreen Cantrell, UK
15:15
Shuttle to Ravenna, guided tour and dinner at local restaurant
TUESDAY 20 MAY


Session 6: Signalling pathways that regulate effector and memory cell differentiation
9:00-9:30
Ed Palmer, Switzerland
9:30-10:00
Susan Kaech, USA
10:00-10:30
Dan Littman, USA
10:30-11:00
Alexander Rudensky, USA
11:00-11:15
1 selected short talk
11:15-11:45
Coffee break

Session 7: Signalling pathways critical for immune cell development
11:45-12:15
Paul Allen, USA
12:15-12:45
Hassan Jumaa, Germany
12:45-13:15
Gary Koretzky, USA
13:15
Lunch

Session 8 : Regulation of lymphocyte activation and fate by other immune cells
14:45-15:15
Sebastian Amigorena, France
15:15-15:45
Claudia Berek, Germany
15:45-16:15
2 selected short talks
16:15-16:45
Coffee break

Session 9 : Lymphocyte activation and differentiation during the course of infectious disease
16:45-17:15
Rafi Ahmed, USA
17:15-17:45
Federica Sallusto, Switzerland
17:45-18:15
Philippe Bousso, France

18:15-18:45
Closing lecture, Carl June, USA
18:45-19:15
Concluding remarks, open discussion about the next conference
20:00
Banquet
22:00
Dance party

WEDNESDAY 21 MAY


Departure

17 May - 21 May 2014
Bertinoro
Italy
meeting website