The Biological and Biomedical Consequences of Protein Moonlighting

Protein moonlighting, the phenomenon of proteins exhibiting more than one unique biological function, is emerging as a factor in both microbial infection and idiopathic disease and a potential source of additional biological network complexity. Unanswered question about protein moonlighting, include: how common is the process, its evolutionary mechanisms, structural biology, how moonlighting proteins can be identified and its role in human and veterinary disease.

Topics
The definition of protein moonlighting and its generality
How to identify moonlighting proteins
Structural biology of protein moonlighting
Evolution of protein moonlighting
Moonlighting proteins in human infectious disease
Role of moonlighting protein in mammalian physiology and pathophysiology
+ show speakers and program
Tuesday 29 July 2014
09:30 - 10:30 Registration and coffee
An Introduction to Protein Moonlighting
Chair: Brian Henderson (University College London, United Kingdom)
Tuesday 29 July 2014
10:30 - 10:40
Welcome Introduction
Brian Henderson (University College London, United Kingdom)
10:40 - 11:20
An Introduction to Protein Moonlighting
Constance Jeffery (University of Illinois at Chicago, U.S.A.)
11:20 - 11:50
How Expensive is Protein Moonlighting
Shelley Copley (University of Colorado Boulder, U.S.A.)
11:50 - 12:05
TBC
Selected Oral Communication
12:05 - 12:20
TBC
Selected Oral Communication
12:20 - 13:30 Lunch and Poster Session
Identification and Structural Biology of Moonlighting Proteins
Chair: Constance Jeffery (University of Illinois at Chicago, U.S.A)
Tuesday 29 July 2014
13:30 - 14:00
Can Bioinformatics Help in the Identification of Moonlighting Proteins?
Juan Cedano (Autonomous University of Barcelona, Spain)
14:00 - 14:30
Proteomic Techniques for Identifying Moonlighting Proteins
Rob Beynon (Institute of Integrative Biology, United Kingdom)
14:30 - 14:45
TBC
Selected Oral Communication
14:45 - 15:00
TBC
Selected Oral Communication
15:00 - 15:30 Tea and Coffee Break
15:30 - 16:00
Structurally Disordered Proteins in Protein Moonlighting
Peter Tompa (Vrije Universiteit Brussel, Belgium)
16:00 - 16:30
Structural Biology of Protein Moonlighting: Lessons from Antibodies
Andrew Martin (University College London, United Kingdom)
16:30 - 16:45
TBC
Selected Oral Communication
16:45 - 17:00
TBC
Selected Oral Communication
17:00 - 17:30 Open Discussion
17:30 - 18:30 Poster Session
19:00 - 21:30 Conference Dinner
Evolutionary Mechanisms of Protein Moonlighting
Chair: Andrew Martin (University College London, United Kingdom)
Wednesday 30 July 2014
09:00 - 09:30
The Evolution of Moonlighting in the Chaperonins
Mario Fares (Trinity College Dublin, Ireland)
09:30 - 10:00
Evolution of Protein Moonlighting: Insight from Yeasts
Carlos Gancedo (Department of Metabolism and Cell Signalling, Spain)
10:00 - 10:15
TBC
Selected Oral Communication
10:15 - 10:30
TBC
Selected Oral Communication
10:30 - 11:00 Tea and Coffee Break
Protein Moonlighting and Microbial Infections
Chair: Constance Jeffery (University of Illinois at Chicago, U.S.A.)
Wednesday 30 July 2014
11:00 - 11:30
An Overview of Protein Moonlighting in Microbial Infection
Brian Henderson (University College London, United Kingdom)
11:30 - 12:00
Moonlighting Bacterial Peptidyl Prolyl Isomerase: A Novel Anti-Bacterial Therapeutic Target
Michael Steinert (Technische Universität Braunschweig, Germany)
12:00 - 12:30
Moonlighting Proteins in Parasitic Protozoa
Michael Ginger (University of Lancaster, United Kingdom)
12:30 - 12:45
TBC
Selected Oral Communication
12:45 - 13:00
TBC
Selected Oral Communication
13:00 - 14:30 Lunch and Poster Session
Protein Moonlighting in Human Health and Disease
Chair: Rob Beynon (Institute of Integrative Biology, United Kingdom)
Wednesday 30 July 2014
14:30 - 15:00
Moonlighting Proteins in Sperm-Egg Interactions
Francois Petit (Université Paris Sud, France)
15:00 - 15:30
Circulating Cell Stress Proteins as Biomarkers of Human Disease
Graham Pockley (Nottingham Trent University, United Kingdom)
15:30 - 16:00
ATPase-Hsp60 Interactions in Human Vasculitis
Jean Eric Alard (University of Munich, Germany)
16:00 - 16:30
Moonlighting Proteins as Therapeutics
Valerie Corrigall (King's College London, United Kingdom)
16:30 Close of Meeting

29 Jul - 30 Jul 2014
London
United Kingdom
meeting website