The Role of Inflammation during Carcinogenesis

There is a growing appreciation that inflammation is the root cause of many cancers. Epidemiological and infectious disease literature supports this hypothesis. In addition, there is a growing body of experimental support confirming the role of inflammation in cancer initiation. However, once tumors are established, this inflammatory response changes and a set of immune cells are recruited that are immunomodulatory and not inflammatory. These types of immune cells, particularly those of the innate system, are also recruited to tumors in which there is no evidence for inflammation as a cause of tumorigenesis. This phenomenon has sometimes been called sterile inflammation. These immune cells enhance tumor progression and metastasis by promoting angiogenesis, enhancing tumor cell migration, invasion and intravasation and suppressing anti-tumor immunity. The conference will address the mechanisms behind the recruitment of the immune cells and their function, the switches in type of inflammatory responses during tumor progression and the actions of these cells in tumor promotion both at the primary and metastatic sites.
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20 May - 25 May 2012
Dublin
Ireland
meeting website