Emerging Concepts and Targets in Islet Biology

The novelty of this meeting will be the focus on basic signaling pathways that identify emerging targets for enhancing the function, promoting survival and/or increasing proliferation of islet cells. We will include potential drug targets that reside in different organ systems that can impact islet cells by inter-organ communication, or are localized to the islet milieu with effects on islet vascularization and innervation, or are products of novel genes that have been recently identified in genetic studies. Efforts will be aimed at assessing the efficacy of drug targeting and will require means to quantitatively assess islet responses in vivo, and focus on non-invasive assessment (biomarkers or imaging) of beta cell mass and/or function.
+ show speakers and program
Sunday, April 6
Arrival and Registration Longs Peak Foyer

Monday, April 7
Keynote Address: C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
Novel Signaling Pathways Relevant for Targeting Metabolism

AM Plenary: New Insights into Beta Cells Signaling Pathways
Rohit N. Kulkarni, Joslin Diabetes Center, Harvard Medical School, USA
Growth Factor Regulation of Proinsulin Processing in Beta Cells
Adolfo Garcia-Ocaña, University of Pittsburgh, USA
Role of PKC-zeta in Beta Cell Signaling
Carmella Evans-Molina, Indiana University, USA
Regulation of ER Calcium Homeostasis in the Diabetic Beta Cell
Short Talk(s) Chosen from Abstracts

Workshop 1: Drug Targets in Clinical Trials

PM Plenary: The Role of Non-Beta Cells in Glucose Homeostasis
Patrik Rorsman, Oxford Centre for Diabetes, Endocrinology and Metabolism, UK
Signaling in the Regulation of Alpha Cells: Role of Calcium and Ion Channels Maureen J. Charron, Albert Einstein College of Medicine, USA
Glucagon Receptor Signaling and its Implications for Glucose Homeostasis
Jeffrey M. Zigman, University of Texas Southwestern Medical Center, USA
Ghrelin Signaling in Modulation of Alpha Cells
Short Talk Chosen from Abstracts

Poster Session 1

Tuesday, April 8
AM Plenary: Novel Drug Targets to Enhance Beta Cell Function
Eckhard Lammert, Heinrich-Heine-University / German Diabetes Center, Germany
Targeting NMDA Receptors to Regulate Beta Cell Secretion
Josephine Egan, NIA, National Institutes of Health, USA
Significance of Targeting Cannabinoids in the Perohepry to Regulate Beta Cell Function and Survival
Erik Renström, Skåne University Hospital, Sweden
Alpha 2A Adrenergic Receptors and Beta Cell Secretion
Mehboob Hussain, Johns Hopkins University School of Medicine, USA
Snapin as a Target of Incretin-Mediated Increase in Glucose-Stimulated Insulin Secretion
Short Talk(s) Chosen from Abstracts

Workshop 2: Update on Investments in Stem Cell/iPS Research

PM Plenary: Novel Drug Targets to Preserve and/or Promote Proliferation of Beta Cells
Raghavendra G. Mirmira, Indiana University School of Medicine, USA
The Role of Deoxyhypusine Synthase/Polyamine Synthesis Inhibitors on Beta Cells Michael R. Hayden†, University of British Columbia and Teva Pharmaceutical Industries Ltd., Canada
The Significance of MicroRNA in Targeting ABC Transporters to Modulate Beta Cell Cholesterol Metabolism
Fumihiko Urano, Washington University School of Medicine, USA
Role for Endoplasmic Reticulum Stress Chaperones in Regulating Beta Cell Survival Short Talk Chosen from Abstracts

Poster Session 2

Wednesday, April 9
AM Plenary: Targeting Extra-Pancreatic Tissues to Regulate Beta Cell Biology - Systemic Communication
Gerard Karsenty, Columbia University Medical Center, USA
Targeting the Bone to Modulate Beta Cell Biology
Pierre Léopold, Université Nice Sophia Antipolis, France
Signals from the Adipose in the Regulation of the Endocrine Pancreas
Speakers to be Announced
Short Talk(s) Chosen from Abstracts

Workshop 3: Discussion on Procurements and Distribution of High Quality Human Islets and Pancreas

PM Plenary: Targeting Local Innervation and Vascularization to Regulate Beta Cell Biology - Intra-Islet Communication
Alejandro Caicedo, University of Miami, USA
Sympathetic Innervation Targets Blood Vessels to Modify Beta Cell Function Per-Ola Carlsson, Uppsala University, Sweden
How Can Vascularization Be Modified to Enhance Beta Cell Function and Mass?
Hans-Michael Dosch, Hospital for Sick Children, Canada
The Role of Schwann Cells in Regulating Beta Cells
Short Talk Chosen from Abstracts

Poster Session 3

Thursday, April 10
AM Plenary: Non-Invasive Assessment of Beta Cell Function and Mass
Speaker to be Announced
Markus Stoffel, Institute of Molecular Health Science, Switzerland
MicroRNAs as Potential Biomarkers of Beta Cells
Eckhard Wolf, Ludwig-Maximilians-Universität (LMU) Munich, Germany
The GIPRdn Pig as a Model to Identify Biomarkers of Subclinical Diabetes
Kevan C. Herold, Yale University, USA
Insulin Gene Methylation as a Marker of Beta Cell Death
Short Talk(s) Chosen from Abstracts

PM Plenary: Novel Genes Involved in Islet Dysfunction
Alan D. Attie, University of Wisconsin-Madison, USA
The Role of Tomosyn 2 in the Regulation of Insulin Secretion
Michael German, University of California, San Francisco, USA
Transcriptional Cascade Controlling Beta-Cell Differentiation
Charlotte A. Ling, Lund University, Sweden
TFBM1 and its Variants as Regulators of Islet Function and Development of Diabetes
Short Talk Chosen from Abstracts

Friday, April 11
Departure

6 Apr - 11 Apr 2014
Keystone
United States of America
meeting website