Exploiting and Understanding Chemical Biotransformations in the Human Microbiome

This conference explores the major challenges that are emerging from this new area of study:
• The biotransformation and resistance to therapeutics
• The discovery of natural products from microorganisms, in the context of the human microbiome and other systems
• Computational approaches to understanding microbial metabolism and biosynthesis
• The potential for synthetic biology to engineer microbiomes
• Therapeutic approaches to manipulate the microbiome
• Host-microbial signaling mechanisms
• The consequences of microbial biotransformations and toxicity on host health and disease

We anticipate this conference could lead to long-lasting collaborative partnerships between individuals with wide-ranging expertise from both academia and industry. This will involve the introduction of state-of-the-art techniques to existing areas of research, along with an attempt to identify general biological themes that influence multiple areas of research.
+ show speakers and program
Tuesday, April 1
Arrival and Registration Lower Atrium

Wednesday, April 2
Keynote Address: Jeffrey I. Gordon, Washington University School of Medicine, USA
Looking Ahead in the Human Microbiome

AM Plenary: Microbial Interactions with Therapeutics
Gerry Wright, McMaster University, Canada
Bacterial Inactivation of Anticancer Drugs
Matthew R. Redinbo, University of North Carolina at Chapel Hill, USA
Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme
Peter J. Turnbaugh, Harvard University, USA
Metabolism of Cardiac Drugs by the Human Gut Microbiota
Short Talk(s) Chosen from Abstracts

PM Plenary: Biosynthesis of Small Molecules and Drug Discovery
Emily Balskus, Harvard University, USA
Discovery and Characterization of Disease-Associated Metabolic Pathways within the Human Gut Microbiota
Michael A. Fischbach, University of California, San Francisco, USA
Natural Products Mediate Microbial Interactions in the Gut
Jörn Piel, University of Bonn, Germany
Discovery of Natural Products from Uncultivated and Cultured Symbionts
Short Talk Chosen from Abstracts

Poster Session 1

Thursday, April 3
AM Computational Approaches to Understanding Microbial Metabolism and Biosynthesis
Elhanan Borenstein, University of Washington, USA
Metagenomic Systems Biology
Joao Xavier, Memorial Sloan-Kettering Cancer Center, USA
Modeling Complex Microbial Communities
Curtis Huttenhower, Harvard School of Public Health, USA
Metabolic Reconstruction from Microbes to Meta'omes
Rob Knight, University of Colorado, USA
Microbial Communities Viewed Over Time and Space
Short Talk(s) Chosen from Abstracts

PM Plenary: Impacts on Host Health and Disease
Christian Jobin, University of North Carolina at Chapel Hill, USA
Genotoxic Bacteria and Cancer Progression
Stanley L. Hazen, Cleveland Clinical Foundation, USA
Links between Microbial Metabolism of Dietary Choline and Atherosclerosis
Eugene B. Chang, University of Chicago, USA
Diet, Microbes and Genetics: The Perfect Storm to Inflammatory Bowel Diseases
Short Talk Chosen from Abstracts

Poster Session 2

Friday, April 4
AM Plenary: Engineering Microbiomes
Sean Davies, Vanderbilt University, USA
Genetically Engineered Therapeutic Bacteria
Christopher Voigt, Massachusetts Institute of Technology, USA
Synthetic Metagenomics
Tom Van de Wiele, Ghent University, Belgium
Simulating the Human Gut Microbiome
Short Talks Chosen from Abstracts

PM Plenary: Therapeutics Approaches to Manipulating the Microbiome
Nathalie Delzenne, Université Catholique de Louvain, Belgium
Prebiotic Approaches to Metabolic Syndrome
Alexander Khoruts, University of Minnesota, USA
Human Fecal Transplantation: Metabolic Effects of Engraftment
Harry Flint, University of Aberdeen, UK
Dietary Modulation of the Gut Microbiota and Metabolism
Liping Zhao, Shanghai Jiao Tong University, China
Dietary Intervention for a Better Gut Microbiome and a Healthy Life

Poster Session 3

Saturday, April 5
AM Plenary: Host-Microbial Interactions
Heidi H. Kong, NCI, National Institutes of Health, USA
Host-Microbial Interactions in Healthy Skin and Dermatologic Disorders
Margaret J. McFall-Ngai, University of Wisconsin, USA
Evolutionarily Conserved Signals of Host-Microbe Interaction: Lessons from the Squid-Vibrio Symbiosis
Katherine P. Lemon, Forsyth Institute, USA
Small-Molecule-Mediated Interactions in the Nostril Microbiota and Pathogen Colonization
Sven Pettersson, Karolinska Institutet, Sweden
Microbial Control of Brain Development and Behavior
Short Talk(s) Chosen from Abstracts

Workshop
Short Talks Chosen from Abstracts

PM Plenary: Unintended Consequences of Antibiotic Use
Roy Kishony, Harvard Medical School, USA
Evolution of Antibiotic Resistance in Humans
Martin J. Blaser, New York University School of Medicine, USA
Early Life Exposure to Antibiotics Promotes Obesity

Closing Keynote Address: David A. Relman, Stanford University, USA
Stability and Resilience in the Human Microbiome

Sunday, April 6
Departure

1 Apr - 6 Apr 2014
Big Sky
United States of America
meeting website