Aging and Diseases of Aging

Age-related diseases and disabilities, such as cancer, diabetes, and neuronal degeneration, pose an ever increasing social and economic burden worldwide. Fortunately, the last decades have witnessed dramatic progress in our understanding of the aging process. Genetic studies in particular have helped elucidate some of the molecular pathways that regulate the aging and offered new insights into the treatment of age-related diseases. However, there is still much to be learned and further progress in addressing the unique challenges of the aging population will require new insights and novel approaches. In order to accelerate the discovery process, this Keystone Symposia meeting will cover essential aspects of the aging processes, including cell signaling pathways, DNA stability, protein homeostasis, stem cells and cellular senescence. Each plenary session will emphasize innovative findings from a variety of models in basic research areas and link them to age-related disease and frailty. The ultimate goal is to provide an opportunity for attendees to communicate and promote an integrated understanding of aging and age-related diseases. The program for this meeting is highly likely to attract a wide variety of investigators, many of whom might not otherwise interact.
+ show speakers and program
MONDAY, OCTOBER 22

16:00—20:00
Arrival and Registration


TUESDAY, OCTOBER 23

07:30—08:30
Breakfast

NOTE: Breakfast at Individual Hotel

Individual Hotel
07:30—08:30
Poster Setup

Daigo
08:30—15:00
Poster Viewing

Daigo
08:30—09:30
Welcome and Keynote Address
Registered attendees can view abstracts starting on 09/22/2012

Daigo
David A. Sinclair, Harvard Medical School, USA
Using Sirtuins to Identify Fundamental causes of Aging and Age-Related Diseases

09:30—12:15
Cell Signaling I
Registered attendees can view abstracts starting on 09/22/2012

Daigo
Leonard P. Guarente, Massachusetts Institute of Technology, USA
Aging and Disease: Connections to Sirtuins

Marcia C. Haigis, Harvard Medical School, USA
Role of Mitochondrial Metabolism in Diseases of Aging

Eisuke Nishida, Kyoto University, Japan
A Fasting-Responsive Signaling Network That Extends Life-Span in C. elegans

Laura Bordone, Genomics Institute of the Novartis Foundation, USA
Regulation of Glucose and Nitrogen Metabolism by SIRT4

Martin S. Denzel†, Max-Planck-Institute for Biology of Ageing, Germany
Short Talk: Enhancing N-glycosylation via Activation of the Hexosamine Pathway Improves ER Protein Folding Capacity and Slows Aging

10:10—10:30
Coffee Break

Foyer
12:15—12:45
Lunch

Foyer/Saga/Daigo
12:30—15:00
Poster Session 1

Daigo
14:30—15:00
Coffee Available

Foyer
15:00—17:00
Cell Signaling II
Registered attendees can view abstracts starting on 09/22/2012

Daigo
Sean M. Oldham, Sanford-Burnham Medical Research Institute, USA
The Role of the TOR Pathway in Obesity and Aging

Shin-ichiro Imai, Washington University School of Medicine, USA
The Systemic Regulatory Network for Mammalian Aging and Longevity: The Importance of SIRT1 and NAMPT in the Hypothalamus and Adipose Tissue

Yousin Suh, Albert Einstein College of Medicine, USA
Functional Genomics of Human Aging

Caroline Kumsta†, Sanford-Burnham Medical Research Institute, USA
Short Talk: The Integrin-Signaling Complex Regulates Longevity and Thermo-Tolerance via HSF-1 in C. elegans

17:00—
On Own for Dinner


WEDNESDAY, OCTOBER 24

07:30—08:30
Breakfast

NOTE: Breakfast at Individual Hotel

Individual Hotel
08:30—11:45
Stem Cells and Aging. Session Sponsored by The Ellison Medical Foundation.
Registered attendees can view abstracts starting on 09/22/2012

NOTE: Support for these organizer-selected speakers generously provided by this foundation.

Daigo
* Kazuo Tsubota, Keio University School of Medicine, Japan

Thomas A. Rando, Stanford University School of Medicine, USA
Epigenetic Mechanisms of Stem Cell Aging and Rejuvenation

Heinrich Jasper, University of Rochester, USA
Proliferative Homeostasis and Aging of the Adult Intestine of Drosophila

Anne Brunet, Stanford University, USA
Epigenetic Regulation of Neural Stem Cell Aging

Amy J. Wagers, Harvard University, USA
Age-Dependent Regulators of Tissue Maintenance and Repair

Mineo Kurokawa, Graduate School of Medicine, University of Tokyo, Japan
Short Talk: Regulation of Stem Cells in Normal and Malignant Hematopoiesis

Anne H. H. Tseng, Academia Sinica and National Yang Ming University, Taiwan
Short Talk: SIRT3 Crosstalks with FOXO3 Acetylation-Phosphorylation-Ubiquitination to Mediate Hypoxic Adaptation

09:50—10:10
Coffee Break

Foyer
11:45—
Poster Setup

Daigo
11:45—16:00
Poster Viewing

Daigo
12:00—15:30
On Own for Lunch and Recreation

15:30—16:00
Coffee Available

Foyer
16:00—18:00
Cell Signaling III
Registered attendees can view abstracts starting on 09/22/2012

Daigo
Yo-ichi Nabeshima, Foundation for Biomedical Research and Innovation, Japan
alpha-Klotho in Health and Diseases

Noboru Mizushima, Tokyo Medical and Dental University, Japan
Autophagy: Its Regulation Mechanism and Selective Substrates

Raul Mostoslavsky, Massachusetts General Hospital, Harvard Medical School, USA
The Chromatin Deacetylase SIRT6 is a Critical Modulator of Cancer Metabolism

Bernadette Zwaans, University of Michigan, USA
Short Talk: SIRT6 Promotes Repetitive Element Silencing

18:00—19:00
Social Hour w/ Lite Bites

Foyer/Saga/Daigo
19:00—22:00
Poster Session 2

Daigo

THURSDAY, OCTOBER 25

07:30—08:30
Breakfast

NOTE: Breakfast at Individual Hotel

Individual Hotel
07:30—08:30
Poster Setup

Daigo
08:30—15:00
Poster Viewing

Daigo
08:30—11:45
DNA Damage Response, Telomeres and Cellular Senescence
Registered attendees can view abstracts starting on 09/22/2012

Daigo
Judith Campisi, Buck Institute for Research on Aging, USA
The DNA Damage Response, Inflammation, and Aging

Manuel Serrano, Spanish National Cancer Center (CNIO), Spain
Tumor Suppressors at the Interface between Cancer and Aging

Fuyuki Ishikawa, Kyoto University, Japan
CST Complex in Telomere DNA Replication

Cynthia T. McMurray, Lawrence Berkeley National Laboratory, USA
Age-Related Instability and Metabolic Status Contribute to Onset of Huntington’s Disease: A Toxic Oxidation Cycle

Victoria P. Belancio†, Tulane University, USA
Short Talk: Circadian Dynamics of L1 Expression in Cancer

Naoko Ohtani, Cancer Institute of JFCR, Japan
Short Talk: Senescence-Associated Secretory Phenotypes (SASPs) Promote Obesity-Associated Hepatocarcinogenesis

09:50—10:10
Coffee Break

Foyer
12:00—12:45
Lunch

Foyer/Saga/Daigo
12:30—15:00
Poster Session 3

Daigo
14:30—15:00
Coffee Available

Foyer
15:00—17:00
Age-Related Neurodegenerative Diseases
Registered attendees can view abstracts starting on 09/22/2012

Daigo
Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Role of Autophagy in Neurodegenerative Diseases

Andrew G. Dillin, The Salk Institute for Biological Studies, USA
Aging as an Event of Proteostasis Collapse

Dale E. Bredesen, Buck Institute for Research on Aging, USA
Role of Cell Death Signaling in Alzheimer's Disease

Baohua Liu, University of Hong Kong, Hong Kong
Short Talk: Depleting Suv39h1 Methyltransferase Rescues Defective DNA Repair and Extends Lifespan in Progeria Mouse Model

17:00—
On Own for Dinner


FRIDAY, OCTOBER 26

07:30—08:30
Breakfast

NOTE: Breakfast at Individual Hotel

Individual Hotel
08:30—11:45
Aging and Metabolic Diseases
Registered attendees can view abstracts starting on 09/22/2012

Daigo
Takashi Kadowaki, University of Tokyo, Japan
AdipoRs Activation Increases Ca2+ and AMPK/SIRT/PGC-1, thereby Regulating Metabolic Stress and Mitochondria, Leading to Anti-Aging and Amelioration of Diseases of Aging

Juleen R. Zierath, Karolinska Institutet, Sweden
Nature or Nurture? Gene/Environment Influence in Skeletal Muscle Insulin Sensitivity in Type 2 Diabetes Patients

Carlos Canto Alvarez, Nestlé Institute of Health Sciences
Modulating NAD+ Levels for Targeting Metabolic Disorders and Age-Related Physiological Decline

Eric M. Verdin, University of California, San Francisco, USA
Mitochondrial Sirtuins: Regulators of Protein Acylation and Metabolism

Yoshito Takeda, Osaka University Graduate School of Medicine, Japan
Short Talk: Double Deletion of CD9 and CD81 in Mice Leads to a Syndrome Resembling Aging

Takashi Ito, Chiba University, Japan
Short Talk: CDC42 and NFkB Signaling Contribute to Pro-Inflammatory Phenotype of Senescent Endothelial Cells

09:50—10:10
Coffee Break

Foyer
11:45—16:30
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Aging and Cardiovascular Diseases
Registered attendees can view abstracts starting on 09/22/2012

Daigo
* Yasuyoshi Ouchi†, University of Tokyo, Japan

Edward G. Lakatta, NIA, National Institutes of Health, USA
The Stress of Aging Viewed from the Arterial Wall

Rolf Bodmer, Sanford-Burnham Medical Research Institute, USA
Cardiac Aging in Drosophila

Hiroshi Itoh, Keio University School of Medicine, Japan
Significance of Renal Tubular Sirt1 in Diabetic Nephrophaty through Epigenetic Modulation of Claudin-1 Gene Expression in Podocytes—Possible Existence of Renal Tubules-Podocytes Communication

Ken Shinmura, Keio University School of Medicine, Japan
Short Talk: Cardiac Sirt1 Is Essential for Caloric Restriction-Induced Cardioprotection against Ischemia/Reperfusion

19:00—20:00
Social Hour w/ Lite Bites

Foyer/Saga/Daigo

SATURDAY, OCTOBER 27


Departure


*Session Chair †Speaker invited, not yet responded.

22 Oct - 27 Oct 2012
Tokyo
Japan
meeting website