Innate Immunity, Metabolism and Vascular Injury

Smoldering inflammation in tissues, whether it is in the vascular bed, white adipose tissue or perivascular fat, is primarily mediated by the innate immune system. This conference will bring together leading investigators in areas of macrophage biology, vascular inflammation, atherosclerosis, and obesity-induced metabolic disease. Sessions will encompass a broad range of topics highlighting the importance of and mechanisms by which innate immunity contributes to progression of metabolic diseases, including monocyte development and trafficking, macrophage activation in vascular bed and adipose tissues, and systems biology of myeloid cells. Exciting new developments in sensing of metabolic stress by inflammasomes, clearance of apoptotic cells by macrophages, and initiation of necrotic cell death programs will also be discussed. These basic studies will be complemented by talks discussing new strategies for promoting plaque regression, and targeting innate inflammation to treat insulin resistance, type 2 diabetes, and coronary artery disease.
+ show speakers and program
Sunday, March 23
Arrival and Registration Grand Foyer

Monday, March 24
Keynote Address
Ruslan M. Medzhitov, HHMI, Yale University School of Medicine, USA
Inflammation and Diseases of Homeostasis

AM Plenary: Monocytes - Development and Disease
Frederic Geissmann, King's College London, UK
Patrolling Monocytes: Policying the Endothelium
Filip K. Swirski, Massachusetts General Hospital, USA
Splenic Monocytes and Atherosclerosis
Alan R. Tall, Columbia University, USA
Regulation of Hematopoiesis by Cholesterol
Short Talk(s) Chosen from Abstracts

Workshop 1
Short Talks Chosen from Abstracts

PM Plenary: Genomics of Myeloid Cells
Christopher K. Glass, University of California, San Diego, USA
A Genome-Wide View of Macrophage Activation
Laszlo Nagy, University of Debrecen, Hungary
Regulation of Macrophage and Dendirtic Cell Gene Expression
Gwendalyn J. Randolph, Washington University, USA
Genomics of Tissue Macrophages
Short Talk Chosen from Abstracts

Poster Session 1

Tuesday, March 25
AM Plenary: Macrophages and Vascular Inflammation (Joint)
Kathryn J. Moore, New York University Medical Center, USA
MicroRNA Modulation of Cholesterol Homeostasis
Christoph J. Binder, Medical University of Vienna, Austria
Innate Sensors of Oxidative Stress
Ira Tabas, Columbia University, USA
Regulation of Inflammation and its Resolution in Atherosclerosis
Peter Tontonoz, HHMI/University of California, Los Angeles, USA
Transcriptional and Post-Transcriptional Regulation of Sterol Metabolism
Short Talk(s) Chosen from Abstracts

PM Plenary: Inflammasomes in Metabolic Disease
Richard A. Flavell, Yale University School of Medicine, USA
Inflammasomes, NFLAD and Obesity
Jenny P. Y. Ting, University of North Carolina at Chapel Hill, USA
Fatty Acid Activation of Inflammasomes
Vishva M. Dixit, Genentech, Inc., USA
The Inflammasome
Short Talk Chosen from Abstracts

Poster Session 2

Wednesday, March 26
AM Plenary: Innate Inflammation and Insulin Resistance
Anthony W. Ferrante, Columbia University, USA
Adipose Tissue Macrophages and Metabolic Disease
Richard M. Locksley, HHMI/University of California, San Francisco, USA
Innate Helper Type 2 Cells in Metabolic Disease
Ajay Chawla, University of California, San Francisco, USA
Macrophages and Brown Fat Metabolism
Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center, USA
Targeting Inflammation to Treat Metabolic Disease
Short Talk(s) Chosen from Abstracts

PM Plenary: Apoptosis and Necrosis
Kodi S. Ravichandran, University of Virginia, USA
Apoptotic Meal: Find-Me and Eat-Me Signals
Shigekazu Nagata, Kyoto University, Japan
Apoptotic Cell Clearance and Autoimmunity
Andres Hidalgo, CNIC, Spain
Clearance of Aged Neutrophils
Short Talk Chosen from Abstracts

Poster Session 3

Thursday, March 27
AM Plenary: Where Are the Missing Genetics in Diabetic Complications? (Joint)
Eric Schadt, Pacific Biosciences/Mount Sinai School of Medicine, USA
What the Genome Isn't Telling Us
Caroline Fox, NHLBI, National Institutes of Health, USA
Exome ChIP and Exome Sequencing as a Tool for Understanding Chronic Kidney Disease
Speakers to be Announced
Short Talk(s) Chosen from Abstracts

Workshop 2
Short Talks Chosen from Abstracts

PM Plenary: Progressing Fat and Regressing Cholesterol
Linda K. Curtiss, The Scripps Research Institute, USA
Perivascular Fat and Atherosclerosis
Edward A. Fisher, New York University School of Medicine, USA
HDL and Atherosclerosis Regression: Getting Rid of Cholesterol and Macrophages from the Plaque
Daniel J. Rader, University of Pennsylvania, USA
Molecular Regulators of Reverse Cholesterol Transport
Short Talk Chosen from Abstracts

Friday, March 28
Departure

23 Mar - 28 Mar 2014
Whistler
Canada
meeting website