Complications of Diabetes (X7)

The meeting content seeks to challenge current research paradigms by introducing novel concepts and experimental approaches, addressing questions about the genetics of complications, for example, with discussions of gene interactions, epigenetics, and networks. Experts in metabolism, stem cell biology, mitochondrial biology, model organisms, and clinical complications will be brought together to provide new perspectives for scientists focused on the problem of developing new approaches to the prevention and treatment of diabetic complications. There is no other meeting of a similar nature providing a venue devoted to discussion of the diverse aspects of tissue dysfunction and damage caused by diabetes. This meeting will have several joint sessions with the simultaneous Keystone meeting on Innate Immunity, Metabolism and Vascular Injury.
+ show speakers and program
Sunday, March 23
Arrival and Registration Grand Foyer

Monday, March 24
Keynote Address: Michael A. Brownlee, Albert Einstein College of Medicine, USA
The Molecular Basis of Diabetic Complications

AM Plenary: Metabolic Dysregulation and the Pathogenesis of Diabetic Cardiovascular Disease
Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Adipocyte Origin of Insulin Resistance, Chronic Inflammation, and Lipotoxicity Domenico Accili, Columbia University, USA
FOXO1, Bile Acid Synthetic Pathways, and Diabetic Atherosclerosis
Christopher B. Newgard, Duke University Medical Center, USA
Metabolomics and Cardiometabolic Disease Mechanisms
Short Talk(s) Chosen from Abstracts

PM Plenary: Stem Cells in Diabetic Tissue Repair
Geoffrey Cash Gurtner, Stanford University, USA
Stem Cell Defects and Impaired Diabetic Wound Healing
Martin Friedlander, The Scripps Research Institute, USA
Endothelial Progenitor Cells and Diabetic Retinopathy
Speaker to be Announced
Short Talk Chosen from Abstracts

Poster Session 1

Tuesday, March 25
AM Plenary: Macrophages and Vascular Inflammation (Joint)
Kathryn J. Moore, New York University Medical Center, USA
MicroRNA Modulation of Cholesterol Homeostasis
Christoph J. Binder, Medical University of Vienna, Austria
Innate Sensors of Oxidative Stress
Ira Tabas, Columbia University, USA
Regulation of Inflammation and its Resolution in Atherosclerosis
Peter Tontonoz, HHMI/University of California, Los Angeles, USA
Transcriptional and Post-Transcriptional Regulation of Sterol Metabolism
Short Talk(s) Chosen from Abstracts

PM Plenary: Emerging Targets for the Treatment of Diabetic Complications
Susan Quaggin, Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, Canada
Targeting the Tie2 Pathway for Diabetic Nephropathy
Dean Li, University of Utah, USA
Robo4
James W. Russell, University of Maryland, USA
Nicotinamide Precursors as a Treatment in the Diabetic Nervous System
Short Talk Chosen from Abstracts

Poster Session 2

Wednesday, March 26
AM Plenary: Clinical Therapies on the Horizon for Diabetic Complications
Daniel J. Drucker, Samuel Lunenfeld Research Institute, Canada
Cardiovascular Effects of GLP1R Agonists
Matthew D. Breyer, Eli Lilly and Company, USA
Treatments for Diabetic Nephropathy
Lijun Wu, Concert Pharmaceuticals, Inc., USA
CTP-499, Possessing Anti-Inflammatory, Anti-Fibrotic and Anti-Oxidative Properties, as a Novel Drug for the Potential Treatment of Diabetic Kidney Disease
Karl Tryggvason, Karolinska Institute, Sweden
Pyridorin
Short Talk(s) Chosen from Abstracts

PM Plenary: Mitochondrial Biolog
Richard J.M. Coward, Bristol University, UK
Effects of Insulin and IGF Signaling on Podocyte Mitochondrial Integrity
Speakers to be Announced
Short Talk Chosen from Abstracts

Poster Session 3

Thursday, March 27
AM Plenary: Where Are the Missing Genetics in Diabetic Complications? (Joint)
Eric Schadt, Pacific Biosciences/Mount Sinai School of Medicine, USA
What the Genome Isn't Telling Us
Caroline Fox, NHLBI, National Institutes of Health, USA
Exome ChIP and Exome Sequencing as a Tool for Understanding Chronic Kidney Disease
Speakers to be Announced
Short Talk(s) Chosen from Abstracts

PM Plenary: Model Systems for Diabetic Complications
Ross L. Cagan, Mount Sinai School of Medicine, USA
Modeling Diabetic Complications in Drosophila
Jens Kroll, Medical Faculty Mannheim, Heidelberg University and DKFZ-ZMBH Alliance, Germany
Modeling Diabetic Complications in Zebrafish
Thomas M. Coffman, Duke University Medical Center, USA
Humanized Mouse Models of Diabetic Nephropathy
Short Talk Chosen from Abstracts

Friday, March 28
Departure


23 Mar - 28 Mar 2014
Whistler
Canada
meeting website