Immunological Mechanisms of Vaccination

Vaccines are remarkably successful in reducing morbidity and mortality from infectious diseases in both developed and developing countries. However, globally, mortality from infectious disease still exceeds 10 million deaths annually reflecting a need for new, more effective and more deployable vaccination approaches. As many of the relatively easy vaccines have already been made, vaccinology is now tackling more difficult diseases, often caused by complex and genetically variable pathogens. A better understanding of the immunological mechanisms underpinning existing and novel vaccines is therefore required. Fortunately, research efforts to uncover new molecular and cellular techniques offer exceptional opportunities for improved vaccine design. A better understanding of the immunology of vaccination will be of value in evidence-based design of new vaccines against major global causes of mortality such as HIV, malaria and tuberculosis, and against emerging infections such as swine influenza and dengue. Advances in immunology, genomics, and systems biology are beginning to offer a deeper understanding of the molecular and cellular mechanisms of host immunity, and the pivotal role played by the innate immune system in shaping the adaptive immune response. This is providing new opportunities to identify new signatures of vaccine immunogenicity and protective efficacy, which should facilitate vaccine development and guide improved vaccine design. The Keystone Symposia meeting on Immunological Mechanisms of Vaccination will bring together an interdisciplinary group of scientists in vaccinology, immunology and pathogen biology, to address recent advances in these fields and their potential for accelerating vaccine design and development.

Global Health Travel Award Deadline: July 17, 2012
+ show speakers and program
THURSDAY, DECEMBER 13

15:00—19:30
Arrival and Registration

16:00—17:30
Welcome and Keynote Address (Joint with Grand Challenges Meeting)
Registered attendees can view abstracts starting on 11/13/2012

Ottawa Convention Center
Bruce A. Beutler, University of Texas Southwestern Medical Center, USA
Genetics and Innate Immunity

17:30—20:00
Social Hour w/ Lite Bites

Adam/Drawing Rooms

FRIDAY, DECEMBER 14

08:00—09:00
Breakfast

Adam/Drawing Rooms
09:00—12:00
Innate Sensing of Pathogens and Vaccines
Registered attendees can view abstracts starting on 11/13/2012

Ballroom
Stephanie C. Eisenbarth, Yale University, USA
NLR Regulation of Dendritic Cell Priming During Immunization

Yan Shi, University of Calgary, Canada
Immune Activation by Force

Dana Philpott, University of Toronto, Canada
NOD Receptors and Adaptive Immunity

William R. Heath, University of Melbourne
Dendritic Cell Receptors and T Cell Induction

Short Talk(s) Chosen from Abstracts

10:20—10:40
Coffee Break

Adam/Drawing Rooms
12:00—13:00
Poster Setup

Adam/Drawing Rooms
12:00—
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Adam/Drawing Rooms
16:30—17:00
Coffee Available

Adam/Drawing Rooms
17:00—19:00
Augmenting Immune Responses to Vaccines
Registered attendees can view abstracts starting on 11/13/2012

Ballroom
Robert A. Seder, NIAID, National Institutes of Health, USA
Optimizing Adaptive Immunity with Immune Adjuvants

Tania H. Watts, University of Toronto, Canada
CD137L (4-1BBL) as an Immune Stimulant in Acute and Chronic Viral Infections

Daniel D. Pinschewer, University of Geneva, Switzerland
LCMV-based Vaccine Vectors: Viral Immunobiology Teaches Vaccinology

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Adam/Drawing Rooms
19:30—22:00
Poster Session 1

Adam/Drawing Rooms

SATURDAY, DECEMBER 15

08:00—09:00
Breakfast

Adam/Drawing Rooms
08:00—09:00
Poster Setup

Adam/Drawing Rooms
09:00—17:00
Poster Viewing

Adam/Drawing Rooms
09:00—12:00
T Cell Memory to Vaccines
Registered attendees can view abstracts starting on 11/13/2012

Ballroom
Ton N. Schumacher, The Netherlands Cancer Institute
Technologies for Tracking T Cell Responses

John T. Harty, University of Iowa, USA
Alternative Strategies for Generating Memory CD8 T Cells by Prime-Boost Immunization

Marc K. Jenkins, University of Minnesota Medical School, USA
Origins of CD4+ Memory T Cells

David Masopust, University of Minnesota, USA
CD8 T Cell Memory Induced by Heterologous Prime-Boost Vaccination

Short Talk(s) Chosen from Abstracts

10:20—10:40
Coffee Break

Adam/Drawing Rooms
12:00—13:00
Lunch

Adam/Drawing Rooms
12:30—15:00
Poster Session 2

Adam/Drawing Rooms
14:30—15:00
Coffee Available

Adam/Drawing Rooms
15:00—17:00
B Cell Memory to Vaccines
Registered attendees can view abstracts starting on 11/13/2012

Ballroom
Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland
Dissecting the Human Immune Response to Pathogens

Michel C. Nussenzweig, Rockefeller University, USA
Human Antibody Responses to HIV

Shane Crotty, La Jolla Institute for Allergy and Immunology, USA
Tfh Cells: Providing T Cell Help for B Cell Responses

Short Talk Chosen from Abstracts

17:00—
On Own for Dinner


SUNDAY, DECEMBER 16

08:00—09:00
Breakfast

Adam/Drawing Rooms
09:00—12:00
Understanding Signatures of Vaccine Protective Efficacy
Registered attendees can view abstracts starting on 11/13/2012

Ballroom
Bali Pulendran, Emory University, USA
Systems Vaccinology

Ennio De Gregorio, Novartis Vaccines and Diagnostics, Italy
Innate Immune Signatures of Vaccine Adjuvants

Rafick P. Sékaly, Vaccine & Gene Therapy Institute, USA
RNA Immunoprofiling of Vaccines

Susan M. Kaech, Yale University School of Medicine, USA
Talk Title to be Determined

Short Talk(s) Chosen from Abstracts

10:20—10:40
Coffee Break

Adam/Drawing Rooms
12:00—13:00
Poster Setup

Adam/Drawing Rooms
12:00—
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Adam/Drawing Rooms
16:30—17:00
Coffee Available

Adam/Drawing Rooms
17:00—19:00
Translating Immunity to Vaccines
Registered attendees can view abstracts starting on 11/13/2012

Ballroom
Dan H. Barouch, Harvard Medical School/Beth Israel Deaconess Medical Center, USA
Novel HIV Vaccine Strategies

Helen McShane, University of Oxford, UK
Clinical Development of TB vaccines

Speaker to be Announced

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Adam/Drawing Rooms
19:30—22:00
Poster Session 3

Adam/Drawing Rooms

MONDAY, DECEMBER 17

08:00—09:00
Breakfast

Adam/Drawing Rooms
09:00—12:00
Immunity and Vaccines Against Global Threats I
Registered attendees can view abstracts starting on 11/13/2012

Ballroom
Adrian V.S. Hill, University of Oxford, UK
Malaria Vaccine Challenges

Speaker to be Announced

Rafi Ahmed, Emory University School of Medicine, USA
Immune Mechanisms in Influenza Vaccination

Dennis L. Kasper, Harvard Medical School, USA
Immune Responses to Polysaccharide Vaccine Antigens

Short Talk(s) Chosen from Abstracts

10:20—10:40
Coffee Break

Adam/Drawing Rooms
12:00—
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Adam/Drawing Rooms
17:00—19:00
Immunity and Vaccines Against Global Threats II
Registered attendees can view abstracts starting on 11/13/2012

Ballroom
Louis J. Picker, Oregon Health & Science University, USA
Cytomegalovirus (CMV) as a Vector for HIV Vaccines

Jerald C. Sadoff, Crucell NV, Netherlands
Vaccine Vectors for HIV and Other Global Threats

Willem A. Hanekom, University of Cape Town, South Africa
Field Studies of TB Vaccines

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Adam/Drawing Rooms
20:00—23:00
Entertainment

Adam Room

TUESDAY, DECEMBER 18


Departure


*Session Chair †Speaker invited, not yet responded.

13 Dec - 18 Dec 2012
Ottawa
Canada
meeting website