Chromatin Mechanisms and Cell Physiology

Chromatin is the physiological form of DNA in eukaryotic cells and thus, serves as template for many basic DNA related processes (e.g. transcription, repair, replication, recombination). Dynamic changes in chromatin structure are essential for the organization and utilization of our genetic information and are mediated by epigenetic mechanisms such as histone/DNA modifications, non-coding RNAs and chromatin remodeling. The establishment, maintenance and plasticity of distinct chromatin states is crucial for embryonic development, cell differentiation and cell type identity, as well as allowing response to environmental cues such as hormones, stress or nutrients. Chromatin dysfunction also significantly contributes to cell transformation and perturbed development. This Keystone meeting will highlight novel findings in mechanisms of dynamic chromatin regulation and their translation into cellular physiology. In particular, we will focus on four fundamental chromatin processes (RNA regulation, transcription and remodeling, DNA damage and repair, DNA replication) in conjunction with normal and perturbed cellular states (cell fate, signal response, cell transformation, epigenetic inheritance). Sessions feature basic and applied research in model systems ranging from plants over fungi to mammals. This open and inclusive program will generate intense discussions, interesting synergies, and a strong bridge connecting basic chromatin research with cellular physiology. This link will be beneficial to further explore the dynamic (mis)-regulation of chromatin based processes in medically relevant research fields investigating complex human disorders or stem cell therapy.
+ show speakers and program
SUNDAY, MARCH 23

16:00—20:00 Arrival and Registration

MONDAY, MARCH 24

07:30—08:30 Breakfast

08:30—11:45 Chromatin Modifications
Registered attendees can view abstracts starting on 02/23/2014

Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
5-Hydroxymethylcytosine: Genome-Wide Distribution, Enzymes and Disease

Ali Shilatifard, Stowers Institute for Medical Research, USA
Enhancer Marking and Regulation during Development and in Disease

Henk Stunnenberg, Nijmegen Centre for Molecular Life Sciences (NCMLS), Netherlands
Talk Title to be Determined

Asifa Akhtar, Max Planck Institute of Immunobiology and Epigenetics, Germany
Dosage Compensation in Drosophila

Jörn Walter, Saarland University, Germany
DNA Methylation and Genome-Wide Sequencing

09:50—10:10 Coffee Break

11:45—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

14:30—16:30 Panel: Epigenetic Inheritance

16:30—17:00 Coffee Available

17:00—19:00 Cell Fate
Registered attendees can view abstracts starting on 02/23/2014

Alexander Meissner, Harvard University, Broad Institute, USA
DNA Methylation Dynamics in Stem Cells and Development

M. Azim Surani, University of Cambridge, UK
Germ Cell Specification in Mice

Amanda G. Fisher, MRC Clinical Sciences Centre, UK
Chromatin and Cell Reprogramming

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 1


TUESDAY, MARCH 25

07:30—08:30 Breakfast

08:30—11:30 Transcription and Chromatin Remodeling
Registered attendees can view abstracts starting on 02/23/2014

Bradley R. Cairns, HHMI/University of Utah, USA
The Regulation of Chromatin Remodeling at Promoters

Huck-Hui Ng, Genome Institute of Singapore, Singapore
Transcriptional Regulatory Networks in Embryonic Stem Cells

Geneviève Almouzni, Centre National de la Recherche Scientifique, France
Nucleosome Dynamics and Histone Variants

Robert E. Kingston, Massachusetts General Hospital, USA
Gene Silencing by Polycomb Group Proteins: Mechanisms and Targeting

Short Talk(s) Chosen from Abstracts

09:50—10:10 Coffee Break

11:30—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

16:30—17:00 Coffee Available

17:00—19:00 Signal Response
Registered attendees can view abstracts starting on 02/23/2014

Paolo Sassone-Corsi, University of California, Irvine, USA
Mammalian Circadian Clock and Metabolism: The Epigenetic Link

Katrin Chua, Stanford University Medical Center, USA
Chromatin Regulation and Genome Maintenance by Mammalian Sirtuins

Ari M. Melnick, Weill Cornell Medical College, USA
IDH Mutations in Leukemia

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 2


WEDNESDAY, MARCH 26

07:30—08:30 Breakfast

08:30—11:30 RNA Regulation
Registered attendees can view abstracts starting on 02/23/2014

Shiv I. S. Grewal, NCI, National Institutes of Health, USA
RNAi-Dependent Formation of Heterochromatin and its Diverse Functions

David C. Baulcombe, University of Cambridge, UK
RNA Silencing Pathways in Plants

Nicholas J. Proudfoot, University of Oxford, UK
Turnover and Function of Non-Coding RNA Polymerase II Transcripts

Ramin Shiekhattar, Wistar Institute, USA
Long Noncoding RNAs with Enhancer-Like Function in Human Cells

Short Talk(s) Chosen from Abstracts

09:50—10:10 Coffee Break

11:30—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

14:30—16:30 Workshop: Epigenetic Therapy/Inhibitors

Short Talks Chosen from Abstracts

16:30—17:00 Coffee Available

17:00—19:00 Cell Transformation
Registered attendees can view abstracts starting on 02/23/2014

Alexander (Sasha) Tarakhovsky, Rockefeller University, USA
Signaling Function of Polycomb

Tony Kouzarides, University of Cambridge, UK
Chromatin Modifying Enzymes: Their Function and Role in Cancer

Toshikazu Ushijima, National Cancer Center Research Institute, Japan
Induction Mechanism of Aberrant Epigenetic Modifications by Chronic Inflammation

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 3

THURSDAY, MARCH 27

07:30—08:30 Breakfast

08:30—11:30 Chromatin Organization
Registered attendees can view abstracts starting on 02/23/2014

Bas van Steensel, Netherlands Cancer Institute, Netherlands
Role of Nuclear Lamina in Genome Organization and Gene Expression

Thomas Jenuwein, Max Planck Institute of Immunobiology and Epigenetics, Germany
Making and Breaking Chromatin

Job Dekker, University of Massachusetts Medical School, USA
The Long Range Landscape of Gene Promoters

Edith Heard, Institut Curie, France
X Inactivation and the Complexities of a Sex Chromosome

Short Talk(s) Chosen from Abstracts

09:50—10:10 Coffee Break

On Own for Lunch and Recreation

16:30—17:00 Coffee Available

17:00—19:00 Epigenetic Inheritance
Registered attendees can view abstracts starting on 02/23/2014

Danny F. Reinberg, HHMI/New York University, USA
Molecular Mechanisms of Epigenetic Inheritance

Shelley L. Berger, University of Pennsylvania, USA
Talk Title to be Determined

Minoo Rassoulzadegan, Université de Nice, France
Non-Mendalian Epigenetic Heredity: Gametic RNAs as Epigenetic Regulators and Transgenerational Signals

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

20:00—23:00 Entertainment


FRIDAY, MARCH 28

Departure

23 Mar - 28 Mar 2014
Oberstdorf
Germany
meeting website