Recombination Mechanisms and genome instability

Failure to repair DNA damage is associated with genome instability, which accelerates ageing and the onset of cancer. The most cytotoxic DNA lesion is the double strand break (DSB). Homologous Recombination is a major DSB repair mechanism with a key role during DNA replication to ensure genome integrity, and during meiosis to warrant proper chromosome segregation. This workshop aims to discuss the recent advances in the mechanisms of recombination and its contribution to genome integrity.
Topics will include:

■Genetics and Biochemistry of recombination
■Replication-recombination interface
■Recombination mechanisms
■Meiotic recombination
■DNA damage response
■Chromosome structure and cohesion
■Genome rearrangements
■Interplay between DSB repair and other nuclear processes
■DSB repair and human disease

+ show speakers and program
Andres Aguilera
CABIMER, University of Seville
Spain

Juan Alonso
Centro Nacional de Biotecnologia, CSIC
Spain

Francisco Antequera
Instituto de Biología Funcional y Genómica, CSIC
Spain

Simon Boulton
Cancer Research UK, South Mimms
UK

Dana Branzei
Fondazione Istituto FIRC di Oncologia Molecolare (IFOM)
Italy

Monica P. Colaiácovo
Harvard Medical School
USA

Vincenzo Costanzo
London Research Institute, South Mimms
UK

Titia De Lange
The Rockefeller University
USA

Bernard de Massy
Institut de Génétique Humaine, CNRS
France

Oscar Fernandez-Capetillo
Centro Nacional de Investigaciones Oncologicas
Spain

Marco Foiani
Fondazione Istituto FIRC di Oncologia Molecolare (IFOM)
Italy

Raimundo Freire
Hospital Universitario de Canarias
Spain

Catherine Freudenreich
Tufts University
USA

Pierre-Henri Gaillard
Centre National de la Recherche Scientifique
France

Jean Gautier
Columbia University Medical Center
USA

Susan Gasser
Friedrich Miescher Institute
 for Biomedical Research
Switzerland

James Haber
Brandeis University
USA

Wolf D. Heyer
University of California Davis
USA

Pablo Huertas
CABIMER, University of Seville
Spain

Neil Hunter
University of California Davis
USA

Hiroshi Iwasaki
Tokyo Institute of Technology
Japan

Maria Jasin
Memorial Sloan-Kettering Cancer Center
USA

Stefan Jentsch
Max Planck Institute of Biochemistry
Germany

Sue Jinks-Robertson
Duke University Medical Center
USA

Jos Jonkers
Netherlands Cancer Institute
The Netherlands

Roland Kanaar
Erasmus University Medical Center
The Netherlands

Scott Keeney
Memorial Sloan-Kettering Cancer Center
USA

Takehiko Kobayashi
National Institute of Genetics
Japan

Stephen Kowalczykowski
University of California Davis
USA

Lumir Krejci
University of Masaryk
Czech Republic

Michael Lichten
Center for Cancer Research, National Cancer Institute
USA

Maria Pia Longhese
Università di Milano-Bicocca
Italy

Massimo Lopes
University of Zurich
Switzerland

Ana Losada Centro Nacional de Investigaciones Oncologicas, Madrid Spain
Kenneth Marians
Memorial Sloan-Kettering Cancer Center
USA

Bénédicte Michel
CNRS, Centre de Génétique Moléculaire
France

Matthew Neale
University of Sussex
UK

Alain Nicolas
Institut Curie, Centre de Recherche
France

Philippe Pasero
Institut de Génétique Humaine, CNRS
France

Thomas Petes
Duke University
USA

John Petrini
Memorial Sloan Kettering Cancer Center
USA

Rodney Rothstein
Columbia University Medical Center
USA

John Rouse
Dundee University
UK

Lorraine Symington
Columbia University Medical Center
USA

Madalena Tarsounas
University of Oxford
UK

Stephen West
Cancer Research UK, South Mimms
UK

Virginia Zakian
Princeton University
USA


21 May - 25 May 2012
Jerez de la Frontera
Spain
meeting website