Fibrosis: From Bench to Bedside

Fibrosis of all the internal organs is increasingly recognized as a deleterious and ominous consequence of, normal aging, repetitive subclinical tissue injury or severe persistent tissue injury. Fibrosis is increasingly seen as the next broad ranging target for therapeutics after Cancer, and there is now a rush to first-in-class therapeutics. The primary cell that lays down fibrotic tissue is the myofibroblast. The biology of myofibroblasts is relatively undeveloped due a lack of definitive markers, and lack of clear ontogeny, until very recently. This new meeting will: a) bring together Biotech, Pharma and Academia in a seamless meeting. b) It will focus on fibrosis as an abnormal wound healing or tissue repair response identifying aberrant developmental pathways, and progenitor cell responses. c) It will have a broad focus on basic biology of myofibroblasts, their progenitors, progenitor ontogeny, and their interaction with the immune system in disease. d) There will be focus on fibrosis as a normal part of aging and the epigenetics involved in maintaining myofibroblasts in an activated state. e) Among the major blocks to progress is the lack of biomarkers for which will be a full session. f) Finally there will be formal presentations from Biotech/Pharma on the most promising new therapeutics in development or clinical trial. All of these highlighted areas are underdeveloped and are rapidly changing, we aim to make the Keystone Fibrosis meeting the Premier International Meeting for anyone with an interest in this disease process. We will aim to bring together academics from a broad range of interest areas, including cancer, vascular biology, stem cell biology, tissue regeneration as well as those with organ specific interests.
+ show speakers and program
SUNDAY, MARCH 23

16:00—20:00 Arrival and Registration

MONDAY, MARCH 24

07:00—08:00 Breakfast

08:00—09:00 Keynote Address
Registered attendees can view abstracts starting on 02/23/2014

Harry (Hal) C. Dietz, Johns Hopkins University School of Medicine, USA
TGF-beta Signaling and Its Role in Fibrogenesis

09:00—11:15 Senescence, Cell Stress and the Fibrogenic Response
Registered attendees can view abstracts starting on 02/23/2014

Judith Campisi, Buck Institute for Research on Aging, USA
The Role of Cellular Senescence in Inflammation and Fibrosis

Dean Sheppard, University of California, San Francisco, USA
Injured Epithelium and TGF-beta Activation

Scott L. Friedman, Mount Sinai School of Medicine, USA
Autophagy Fuels Fibrosis

Short Talk(s) Chosen from Abstracts

09:40—10:00 Coffee Break

11:15—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

16:30—17:00 Coffee Available

17:00—19:00 Metabolic Pathways in Fibrogenesis
Registered attendees can view abstracts starting on 02/23/2014

Rik Derynck, University of California, San Francisco, USA
TGF-beta Mediates Maladaptive Metabolic Responses to Stress

Erwin P. Böttinger, Mount Sinai School of Medicine, USA
Mitochondrial Dysfunction and Renal Fibrogenesis

Nelson Chau, Regulus Therapeutics, USA
MicroRNA21 and Lipid Metabolism in Fibrogenesis

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 1


TUESDAY, MARCH 25

07:00—08:00 Breakfast

08:00—11:00 Perivascular Mesenchymal Cells - Bipolar Cells in Microvascular Disease and Fibrogenesis
Registered attendees can view abstracts starting on 02/23/2014

Jeremy S. Duffield, University of Washington, USA
Mechanisms of Perivascular Cell Activation in Kidney Disease

Lucie Peduto, Institut Pasteur, France
The Fate and Function of ADAM12 Mesenchymal Cells in Fibrosis

Christian Göritz, Karolinska Institutet, Sweden
The Role of Pericytes in Central Nervous System Scarring and Fibrosis

Jonathan M. Graff, University of Texas Southwestern Medical Center, USA
Give Me a Pill Not a Treadmill: Fibrogenic Stem Cell Reprogramming Cures Obesity and Diabetes

Short Talk(s) Chosen from Abstracts

09:20—09:40 Coffee Break

11:00—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

14:30—16:30 Workshop 1: What Is the Role of Acute and Chronic Infections in Fibrogenesis?

Short Talks Chosen from Abstracts

16:30—17:00 Coffee Available

17:00—19:00 Innate Immunity and Inflammation in Fibrogenesis
Registered attendees can view abstracts starting on 02/23/2014

Paul Kubes, University of Calgary, Faculty of Medicine, Canada
Intravascular Immunity in the Development and Resolution of Sterile Injury

Anthony J. Coyle, Pfizer, USA
TNF Blockade in Lung Fibrosis

John P. Iredale, University of Edinburgh, UK
Macrophages and Resolution of Liver Fibrosis

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 2


WEDNESDAY, MARCH 26

07:00—08:00 Breakfast

08:00—11:00 Established and Promising New Pathways Entering Clinical Development
Registered attendees can view abstracts starting on 02/23/2014

Paul W. Noble, Cedars-Sinai Medical Center, USA
Update on Clinical Trials in IPF

Speaker to be Announced

Speaker to be Announced
Fibrosis Trial in IPF

Andrew M. Tager, Massachusetts General Hospital, USA
LPA1 in Fibrogenesis

Short Talk(s) Chosen from Abstracts

09:20—09:40 Coffee Break

11:00—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

16:30—17:00 Coffee Available

17:00—19:00 Adaptive Immunity in Fibrogenesis
Registered attendees can view abstracts starting on 02/23/2014

Speaker to be Announced
Representative from Novartis:Trials Using Anti-IL 13 Antibodies in Lung Disease

Thomas A. Wynn, NIAID, National Institutes of Health, USA
Mechanisms of T Cell Mediated Fibrosis in Lung and Liver

Speaker to be Announced

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 3


THURSDAY, MARCH 27

07:00—08:00 Breakfast

08:00—11:00 Resolution of Fibrosis and Pathways of Repair/Regeneration
Registered attendees can view abstracts starting on 02/23/2014

Bruno Péault, University of California, Los Angeles, USA
Role of Vascular Pericytes in Normal and Pathologic Tissue Regeneration

Gabrielle Kardon, University of Utah, USA
Interactions between Muscle Stem Cells, Fibroblasts, and Macrophages Are Critical for Muscle Regeneration

Stuart Forbes, University of Edinburgh, UK
Liver Regeneration

Speaker to be Announced

Short Talk(s) Chosen from Abstracts

09:20—09:40 Coffee Break

On Own for Lunch and Recreation

14:30—16:30 Workshop 2: Non-Invasive Monitoring of Fibrosis, Biomarkers and Devices

Short Talks Chosen from Abstracts

16:30—17:00 Coffee Available

17:00—19:00 Myofibroblast Reprogramming
Registered attendees can view abstracts starting on 02/23/2014

David A. Brenner, University of California, San Diego Health Sciences, USA
Myofibroblast Reversion in the Resolution of Fibrosis

Jelena Mann, Newcastle University, UK
Epigenetics in Myofibroblast Reprogramming

Boris Hinz, University of Toronto, Canada
Environment and Its Effect on Myofibroblasts

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

20:00—23:00 Entertainment


FRIDAY, MARCH 28

Departure

23 Mar - 28 Mar 2014
Keystone
United States of America
meeting website