Lipid Pathways in Biology and Disease

Lipids are hydrophobic small molecules required for life that carry out a multitude of critical functions. Lipids can act as hormones, intermediate signaling molecules, vitamins, structural elements in biological membranes and vehicles for energy storage. Disruptions in their levels of expression, as in obesity, diabetes, autoimmunity or certain inborn errors of lipid metabolism, promote profound disease states derived from dysfunctions in a broad spectrum of human organs. Key gaps in our understanding of these dysfunctions include the signaling cascades in which lipid intermediates operate, missing steps in regulatory mechanisms that control lipid synthesis and storage, and poorly described processes whereby various cell types respond to lipid overload. Thus the goals of this conference are to attract researchers at all career stages from multiple disciplines of lipid biology, and to address several central problems in the field: 1. How do disrupted lipid signaling pathways integrate with metabolic regulation to cause cellular dysfunction and metabolic/cardiovascular disease? 2. What are the mechanisms that control the cell biology of lipid storage and release? 3. How do genetic and epigenetic mechanisms control lipid metabolism and related disease? 4. How do various routes of adipogenesis control lipid-related energy expenditure? Of particular interest will be discussion of new technologies for lipid analysis and function in biology and medicine, for which a workshop will be included from abstract submissions. There will also be optimal opportunities for oral presentations of the latest data on all of the above topics to be selected from submitted abstracts.
+ show speakers and program
WEDNESDAY, MARCH 19

16:00—20:00 Arrival and Registration

THURSDAY, MARCH 20

07:00—08:00 Breakfast

08:00—09:00 Keynote Session
Registered attendees can view abstracts starting on 02/19/2014

Stephen O'Rahilly, University of Cambridge, UK
Human Metabolic Disease: Lessons from Genetics

Luke A. J. O'Neill, Trinity College Dublin, Ireland
Talk Title to be Determined

09:30—11:00 Lipids as Signaling Molecules I
Registered attendees can view abstracts starting on 02/19/2014

Sarah Spiegel, Virginia Commonwealth University School of Medicine, USA
S-1-P in Cell Biology and Disease

Scott A. Summers, Duke-NUS Graduate Medical School, Singapore
Ceramide Signaling and Metabolic Disease

George Kunos, NIAAA, National Institutes of Health, USA
Endocannabinoid/CB1 Receptor Signaling in Peripheral Tissues as a Therapeutic Target in Obesity/Diabetes

Michael P. Czech, University of Massachusetts Medical School, USA
Lipid Signaling in Adipocytes

09:40—10:00 Coffee Break

11:30—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

16:30—17:00 Coffee Available

17:00—19:00 Lipids as Signaling Molecules II
Registered attendees can view abstracts starting on 02/19/2014

* Paul F. Pilch, Boston University School of Medicine, USA

Daniele Piomelli, University of California, Irvine, USA
Neuronal Endocannabinoid Signaling and Energy Metabolism

Charles N. Serhan, Brigham and Women's Hospital, USA
Resolvins: Novel Mediators Derived from Polyunsaturated Fatty Acids

Garret A. FitzGerald, University of Pennsylvania, USA
Prostaglandins and Inflammatory Responses

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 1


FRIDAY, MARCH 21

07:00—08:00 Breakfast

08:00—11:00 Linking Metabolism to Gene Expression
Registered attendees can view abstracts starting on 02/19/2014

Jay D. Horton, University of Texas Southwestern Medical Center, USA
Hepatic Lipogenesis

Rosalind A. Coleman, University of North Carolina at Chapel Hill, USA
Triglyceride Synthesis and Signaling

Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA
Glycolytic Regulation of Cell Proliferation

Morris J. Birnbaum, University of Pennsylvania, USA
Insulin Signaling to Gluconeogenesis

Short Talk(s) Chosen from Abstracts

09:20—09:40 Coffee Break

11:00—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

16:30—17:00 Coffee Available

17:00—19:00 Packaging Neutral Lipids into Lipid Droplets
Registered attendees can view abstracts starting on 02/19/2014

* Robert V. Farese Jr., University of California, San Francisco, USA

Tobias C. Walther, Yale University, USA
Triglyceride Synthesis and Storage in Lipid Droplets

Hongyuan Yang, University of New South Wales, Australia
Seipin Function in Lipid Droplet Expansion

David B. Savage, University of Cambridge, UK
Genetic Disorders of Lipid Storage

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 2


SATURDAY, MARCH 22

07:00—08:00 Breakfast

08:00—11:00 Unconventional Lipid Droplet Functions
Registered attendees can view abstracts starting on 02/19/2014

* Dawn L. Brasaemle, Rutgers University, USA

Michael A. Welte, University of Rochester, USA
Lipid Droplets as Sites to Sequester Proteins from other Cellular Compartments

Carole Sztalryd, VAH and University of Maryland School of Medicine, USA
Lipid Droplet Coat: An Adaptation to Cellular Energetic Needs

Russell A. DeBose-Boyd, University of Texas Southwestern Medical Center, USA
Lipid Droplet Function in ER Associated Protein Degradation

John McLauchlan, University of Glasgow, UK
Lipid Droplet Function in Hepatitis C Virus Infection

Short Talk(s) Chosen from Abstracts

09:20—09:40 Coffee Break

11:00—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

16:30—17:00 Coffee Available

17:00—19:00 New Insights into Control of Lipogenesis
Registered attendees can view abstracts starting on 02/19/2014

David M. Sabatini, Whitehead Institute for Biomedical Research, USA
mTOR as a Key Lipogenic Signaling Node

Mitchell A. Lazar, University of Pennsylvania School of Medicine, USA
Hepatic Lipogenesis Regulations through HDAC

Catherine Postic, Institut Cochin INSERM U 567/ CNRS UMR 8104, France
ChREBP Regulation of Lipogenesis

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 3


SUNDAY, MARCH 23

07:00—08:00 Breakfast

08:00—11:00 Lipids in Human Disease
Registered attendees can view abstracts starting on 02/19/2014

* Gerald I. Shulman, HHMI/Yale University School of Medicine, USA

Kitt F. Petersen, Yale University School of Medicine, USA
Ectopic Lipid Accumulation and Insulin Resistance

Barbara B. Kahn, BIDMC and Harvard Medical School, USA
Systemic Metabolic Effects of Adipose Tissue Lipogenesis

Juleen R. Zierath, Karolinska Institutet, Sweden
Lipid Pathways and Regulation of Skeletal Muscle

Daniel J. Rader, University of Pennsylvania, USA
New Pathways in Hepatic Lipid Metabolism

Short Talk(s) Chosen from Abstracts

09:20—09:40 Coffee Break

On Own for Lunch and Recreation

14:30—16:30 Workshop: Therapeutic Strategies from Lipid Pathways

Short Talks Chosen from Abstracts

16:30—17:00 Coffee Available

17:00—19:00 Adipogenesis and "Britening" of White Fat
Registered attendees can view abstracts starting on 02/19/2014

* Silvia Corvera, University of Massachusetts Medical School, USA

Barbara Cannon, Stockholm University, Sweden
White Fat, Brown Fat and 'Brite' Fat

Sheila Collins, Sanford-Burnham Medical Research Institute, USA
Talk Title to de Determined

James G. Granneman, Wayne State University School of Medicine, USA
Progenitors of Brite Adipocytes

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

20:00—23:00 Entertainment


MONDAY, MARCH 24

Departure



19 Mar - 24 Mar 2014
Dublin
Ireland
meeting website