Tumor Metabolism

The recent discovery of mutations affecting metabolic enzymes such as succinate dehydrogenase, fumarate hydratase, and isocitrate dehydrogenase provides genetic evidence that altered cellular metabolism can cause cancer. Moreover, it has become apparent that a number of proteins that regulate processes pertinent to cellular transformation, such as enzymes that affect chromatin structure, respond to specific cellular metabolites. Finally, technologies for monitoring cellular metabolism are improving rapidly including technologies that lend themselves to non-invasive imaging. The goals of this meeting are to bring together a diverse group of scientists from academia and industry with basic and translational interests surrounding cancer metabolism. A particular focus will be on metabolic enzymes as potential targets for treating and/or imaging cancer cells. Toward this end this meeting hopes to attract a diverse group of scientists including biologists, chemists, and engineers. This meeting should provide participants with a greater understanding of the language and logic of cellular metabolism and provide a sense of the translational opportunities emerging from our growing knowledge of the role that altered metabolism plays in cancer.
+ show speakers and program
SUNDAY, MARCH 16

16:00—20:00 Arrival and Registration


MONDAY, MARCH 17

07:00—08:00 Breakfast

08:00—09:30 Keynote Session (Joint)
Registered attendees can view abstracts starting on 02/16/2014

M. Celeste Simon, HHMI/University of Pennsylvania, USA
Oxygen, Lipids and Cancer Cell Metabolism

Steven L. McKnight, University of Texas Southwestern Medical Center, USA
Acetyl-CoA as a Central Node in Cancer Metabolism

09:30—09:50 Coffee Break

09:50—12:00 Novel Metabolic Pathways in Cancer (Joint)
Registered attendees can view abstracts starting on 02/16/2014

Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA
Glutamine and Serine Metabolism

David M. Sabatini, Whitehead Institute for Biomedical Research, USA
Amino Acids, Sugars and Cancer Metabolism

Karen H. Vousden, Beatson Institute for Cancer Research, UK
p53 and Metabolism

Ralph J. DeBerardinis, University of Texas Southwestern Medical Center, USA
Metabolic Versatility in Cancer Cells

11:15—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

14:30—16:30 Workshop: Monitoring Metabolism

Hilary A. Coller, Princeton University, USA
Metabolism of Quiescent Cells

Hank F. Kung, University of Pennsylvania, USA
Novel PET Probes Based on Altered Tumor Metabolism

Linda C. Hsieh-Wilson, California Institute of Technology, USA
The Interplay of Protein Glycosylation and Cancer Metabolism

Alan Saghatelian, Harvard University, USA
Protein-Metabolite Interactions

16:30—17:00 Coffee Available

17:00—19:00 Succinate Dehydrogenase and Fumarate Hydratase
Registered attendees can view abstracts starting on 02/16/2014

Patrick J. Pollard, University of Oxford, UK
Pathogenesis of Fumarate Hydratase Mutations

Eyal Gottlieb, Beatson Institute for Cancer Research, UK
Targeting FH Mutant Tumors

Navdeep S. Chandel, Northwestern University, USA
Krebs Cycle Mutations and Cancer

Short Talk Chosen from Abstracts


Following Session is for Metabolism and Angiogenesis (X5)

17:00—19:00 Metabolism and Vascular Branching I
Registered attendees can view abstracts starting on 02/16/2014

Speaker to be Announced

Massimo Santoro, University of Torino, Italy
Novel Non-Mitochondrial Redox Regulator in Endothelial Cells

Kari K. Alitalo, University of Helsinki, Finland
Metabolic Effects of VEGF-B

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 1


TUESDAY, MARCH 18

07:00—08:00 Breakfast

08:00—11:00 Isocitrate Dehydrogenase
Registered attendees can view abstracts starting on 02/16/2014

William G. Kaelin, Jr., Dana Farber Cancer Institute, USA
Transformation by Mutant IDH

Craig B. Thompson, Memorial Sloan-Kettering Cancer Center, USA
Epigenetic Control by Mutant IDH

Elizabeth Maher, University of Texas Southwestern Medical Center, USA
Metabolic Imaging of IDH Mutant Brain Tumors

Katharine E. Yen, Agios Pharmaceuticals, USA
Targeting Mutant IDH

Short Talk(s) Chosen from Abstracts


Following Session is for Metabolism and Angiogenesis (X5)

08:00—11:00 Metabolism and Vascular Branching II
Registered attendees can view abstracts starting on 02/16/2014

Michael Potente, Max-Planck-Institute for Heart and Lung Research, Germany
Linking Angiogenesis and Metabolism through FOXO Transcription Factors

Peter F. Carmeliet, University of Leuven, VIB, Belgium
Targeting Glycolysis in Vascular Branching

Christer Betsholtz, Karolinska Institutet, Sweden
Lipid Signals in Vascular Quiescence

M. Luisa Iruela-Arispe, University of California, Los Angeles, USA
Endothelial VEGFR2 Signaling in Diabetes

Short Talk(s) Chosen from Abstracts

09:20—09:40 Coffee Break

11:00—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

16:30—17:00 Coffee Available

17:00—19:00 Lactate and Monocarboxylate Transporters
Registered attendees can view abstracts starting on 02/16/2014

Michael P. Lisanti, University of Manchester, UK
Changing the Cancer Paradigm: New Strategies for Personalized Medicine and Drug Discovery

Jacques Pouysségur, University of Nice, France
Hypoxic-Regulation of MCT Transporters

John Kurhanewicz, University of California, San Francisco, USA
Using I\in Vivo Hyperpoalrized 13C MR Imaging for Measuring Metabolic Fluxes Important to Cancer Progression and Therapeutic Response

Short Talk Chosen from Abstracts


Following Session is for Metabolism and Angiogenesis (X5)

17:00—19:00 Novel Metabolic Pathways in Cancer II
Registered attendees can view abstracts starting on 02/16/2014

James M. Phang, NCI at Frederick, CCR, NIH, USA
The Proline Metabolic Axis and Cancer

Yury I. Miller, University of California, San Diego, USA
Cholesterol Efflux and Angiogenesis

Holger Gerhardt†, London Research Institute, UK
Talk Title to be Determined

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 2


WEDNESDAY, MARCH 19

07:00—08:00 Breakfast

08:00—11:00 Metabolism and Epigenetic Enzymes
Registered attendees can view abstracts starting on 02/16/2014

Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
Talk Title to be Determined

Leonard P. Guarente, Massachusetts Institute of Technology, USA
SIRTs in Cancer and Aging

Chuan He, University of Chicago, USA
Epigenetic DNA and RNA Demethylation in Mammalian Regulation

Anne Brunet, Stanford University, USA
Metabolic and Epigenetic Regulation of Aging

Short Talk(s) Chosen from Abstracts


Following Session is for Metabolism and Angiogenesis (X5)

08:00—11:00 Metabolism and Anti-Angiogenic Therapy
Registered attendees can view abstracts starting on 02/16/2014

Rakesh K. Jain, Massachusetts General Hospital, USA
Alleviating Tumor Hypoxia for Cancer Treatment

Patrizia Agostinis, KU Leuven, Belgium
Vessel Normalization by the Autophagy Blocker Chloroquine

Olivier Feron, UCLouvain, Belgium
Targeting Lactate in Angiogenesis

Adrian L. Harris, University of Oxford, Weatherall Institute of Molecular Medicine, UK
Metabolic Response to Anti-Angiogenic Therapy

Short Talk(s) Chosen from Abstracts

09:20—09:40 Coffee Break

11:00—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

16:30—17:00 Coffee Available

17:00—19:00 Lipid Metabolism
Registered attendees can view abstracts starting on 02/16/2014

Daniel K. Nomura, University of California, Berkeley, USA
Mapping Dyregulated Metabolic Pathways in Cancer Using Functional Proteomic and Metabolomic Platforms

Gerald Hoefler, Medical University of Graz, Austria
Lipid Metabolism and Cancer Cachexia

Ernst R. Lengyel, University Of Chicago, USA
Crosstalk between Cancer Cells and Adipocytes

Short Talk Chosen from Abstracts


Following Session is for Metabolism and Angiogenesis (X5)

17:00—19:00 Metabolism and Pathological Angiogenesis
Registered attendees can view abstracts starting on 02/16/2014

Yoshiaki Kubota, Keio University, Japan
Oxidative Stress as a Target for Anti-Angiogenic Therapy

Michael Simons, Yale University, USA
Vascular Fate Determination and Metabolism

Massimiliano Mazzone, KU Leuven, Belgium
Influence of Macrophage Metabolism on Vessel Shape: Implications for Cancer

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 3


THURSDAY, MARCH 20

07:00—08:00 Breakfast

08:00—11:00 Novel Cancer Metabolic Targets (Joint)
Registered attendees can view abstracts starting on 02/16/2014

Almut Schulze, Cancer Research UK, UK
Phosphofructokinase

Jonathan Hurov, Agios Pharmaceuticals, USA
Targeting Cancer Metabolism

Douglas R. Green, St. Jude Children's Research Hospital, USA
Sphingolipid Metabolism

Peter K. Jackson, Stanford University, USA
Targeting Glycolysis

Short Talk(s) Chosen from Abstracts

09:20—09:40 Coffee Break

On Own for Lunch and Recreation

16:30—17:00 Coffee Available

17:00—19:00 Novel Cancer Metabolic Targets II
Registered attendees can view abstracts starting on 02/16/2014

Benjamin F. Cravatt III, The Scripps Research Institute, USA
Targeting Lipid Metabolism

Sandaruwan Geeganage, Eli Lilly and Company, USA
NAMPT Inhibitors and Cancer

Nissim Hay, University of Illinois at Chicago, USA
Targeting Glucose Metabolism for Cancer Therapy

Short Talk Chosen from Abstracts


Following Session is for Metabolism and Angiogenesis (X5)

17:00—19:00 Metabolism and Angiogenesis: Therapeutic Implications
Registered attendees can view abstracts starting on 02/16/2014

George D. Yancopoulos, Regeneron Pharmaceuticals, Inc., USA
Targeting VEGF and VEGF-Trap

Napoleone Ferrara, University of California, San Diego, USA
Targeting VEGF for Therapy of Cancer and Intraocular Neovascular Disorders

Douglas Hanahan, ISREC, Switzerland
Targeting Angiogenesis in Cancer

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

20:00—23:00 Entertainment


FRIDAY, MARCH 21

Departure



16 Mar - 21 Mar 2014
Whistler
Canada
meeting website