Immune Evolution in Cancer

Neoplastic progression is initiated by accumulations of somatic mutations in proliferating cells resulting in alterations of once “healthy” cells to sustain survival programs and resist embedded tissue-based programs designed to restrain their unchecked proliferation. Concurrent with neoplastic progression, the immune system sculpts the neoplastic cell repertoire by eliminating immunogenic cells while allowing outgrowth of less immunogenic variants, a process known as immunoediting. As neoplasms undergo early progression, they often resemble a chronic “wound” wherein activated tissue remodeling, and immune and angiogenic programs are characteristic of wound healing and facilitate the survival of potentially malignant cells. Cells of the adaptive and innate immune systems are particularly important during wound healing, however during cancer development, many immune cells are co-opted and effectively “reprogrammed” towards a tumor-promoting phenotype. As a result, malignant cells condition their environment to facilitate their progression by co-opting multiple immune effector cell populations. Presentations at this conference will focus on how the tumor microenvironment perturbs lymphoid and myeloid cells, the mechanisms used by immune cells to promote tumor growth, and the strategies being developed to counteract tumor-induced immune suppression to generate anti-tumor immunity. Many of the tumor-promoting effects of the immune system are regulated by leukocyte infiltration, e.g., chronic inflammation, thus this conference in conjunction with the companion conference “Inflammation, Infection, and Cancer,” will provide an in depth examination of the current understanding of tumor progression, and will facilitate interactions between tumor immunologists and cancer biologists.
+ show speakers and program
SUNDAY, MARCH 9

16:00—20:00 Arrival and Registration

MONDAY, MARCH 10

07:00—08:00 Breakfast

08:00—10:00 Keynote Session (Joint)
Registered attendees can view abstracts starting on 02/09/2014

Robert D. Schreiber, Washington University School of Medicine, USA
Immunoediting in the Tumor Microenvironment

Alexander Y. Rudensky, HHMI/Memorial Sloan-Kettering Cancer Center, USA
Regulatory T Cells, Inflammation and Cancer

10:00—10:20 Coffee Break

10:20—12:00 Inflammation and Immunity in the Tumor Microenvironment (Joint)
Registered attendees can view abstracts starting on 02/09/2014

Andrew J. Dannenberg, Weill Medical College of Cornell University, USA
Obesity-Inflammation Connection: Implications for Breast Cancer

Jeffrey W. Pollard, Queen's Medical Research Institute, UK
Monocyte and Macrophage Heterogeneity and Tumor Progression

Lisa M. Coussens, Oregon Health & Sciences University, USA
Impact of Innate and Adaptive Immunity on Cancer-Associated Chronic Inflammation

Short Talk(s) Chosen from Abstracts

12:00—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

16:30—17:00 Coffee Available

17:00—19:00 Location, Location, Location: Stromal Cell Effects
Registered attendees can view abstracts starting on 02/09/2014

Ronen Alon, Weizmann Institute of Science, Israel
Tumor-Driven Extravasation of Leukocytes

Kornelia Polyak, Dana-Farber Cancer Institute, Harvard Medical School, USA
Leukocytes in Breast Tumor Progression

Shannon J. Turley, Dana-Farber Cancer Institute, Harvard Medical School, USA
Influence of the Stromal Niche on Leukocyte Function in Solid Tumors

Short Talk Chosen from Abstracts


Following Session is for Inflammation, Infection and Cancer (X1)

17:00—19:00 Chronic Inflammation and Cancer
Registered attendees can view abstracts starting on 02/09/2014

Timothy C. Wang, Irving Cancer Research Center, Columbia University, USA
GI Infection, Inflammation and Tumor Microenvironment

Dafna Bar-Sagi, New York University School of Medicine, USA
Pancreatitis as an Initiating Event in Pancreatic Cancer

Robert F. Schwabe, Columbia University, USA
Inflammation, Toll-Like Receptor Signaling and Liver Cancer

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 1

TUESDAY, MARCH 11

07:00—08:00 Breakfast

08:00—11:00 Co-Opting of Anti-Tumor Immunity by Myeloid-Derived Suppressor Cells
Registered attendees can view abstracts starting on 02/09/2014

Olivera J. Finn, University of Pittsburgh School of Medicine, USA
MDSC in Premalignant Disease

Dmitry I. Gabrilovich, University of South Florida, USA
Mechanisms Regulating MDSC in Tumor Microenvironment

Suzanne Ostrand-Rosenberg, University of Maryland, USA
Inflammation and Alarmins as Drivers of MDSC

Vincenzo Bronte, University of Verona, Italy
Tumor-Induced Immune Suppression by MDSC

Short Talk(s) Chosen from Abstracts


Following Session is for Inflammation, Infection and Cancer (X1)

08:00—11:00 Infection and Cancer Initiation
Registered attendees can view abstracts starting on 02/09/2014

Martyn Plummer, International Agency for Research on Cancer, France
The Global Burden of Cancer Attributable to Infection

Cynthia L. Sears, Johns Hopkins University School of Medicine, USA
Colonic Commensals, B. fragilis and Colorectal Cancer

Xiao-Fan Wang, Duke University Medical Center, USA
HBV Infection, MicroRNAs and Metastasis

Elizabeth P. Murchison, University of Cambridge, UK
Transmissible Facial Cancer in Tasmanian Devils as a Model of Infectious Cancer

Short Talk(s) Chosen from Abstracts

09:20—09:40 Coffee Break

11:00—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

16:30—17:00 Coffee Available

17:00—19:00 Re-Educating Tumor-Promoting Macrophages (Joint)
Registered attendees can view abstracts starting on 02/09/2014

Alberto Mantovani, Istituto Clinico Humanitas/ Milan University, Italy
Inflammation, Macrophage Polarization, and Cancer

Jo A. Van Ginderachter, VIB-Vrije Universiteit Brussel, Belgium
Macrophage Plasticity in the Tumor Microenvironment

Johanna A. Joyce, Memorial Sloan-Kettering Cancer Center, USA
Re-Educating Macrophages in the Tumor Microenvironment

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 2


WEDNESDAY, MARCH 12

07:00—08:00 Breakfast

08:00—11:00 Evolving Immune Suppressive Mechanisms in the Tumor Microenvironment
Registered attendees can view abstracts starting on 02/09/2014

Frank Marini, Wake Forest School of Medicine, USA
Mesenchymal Stem Cells in the Tumor Microenvironment

Ruth Ganss, Western Australian Institute for Medical Research, Australia
Tumor-Targeted Therapy to Modulate Stroma

Arthur Hurwitz, National Cancer Institute, National Institutes of Health, USA
Immune Suppressive Properties of Tumor-Associated Mast Cells

Bill C. Dougall, Amgen, USA
RANKL and Bone Metastasis

Short Talk(s) Chosen from Abstracts


Following Session is for Inflammation, Infection and Cancer (X1)

08:00—11:00 The Impact of the Microbiome on Cancer
Registered attendees can view abstracts starting on 02/09/2014

Fiona M. Powrie, University of Oxford, UK
Cellular and Molecular Pathways that Promote Inflammation-Driven Cancer

Wendy S. Garrett, Harvard School of Public Health, USA
Host Microbiota, Colitis and Cancer

Eric G. Pamer, Memorial Sloan-Kettering Cancer Center, USA
Analysis of Diverse Intestinal Microbiomes

Johanna Lampe, Fred Hutchinson Cancer Research Center, USA
Effects of Diet and Modulation of Inflammation on Cancer Risk

Short Talk(s) Chosen from Abstracts

09:20—09:40 Coffee Break

11:00—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

16:30—17:00 Coffee Available

17:00—19:00 Antigen Presentation in the Tumor Microenvironment
Registered attendees can view abstracts starting on 02/09/2014

Jose Conejo-Garcia, Wistar Institute, USA
Satb1 Is the Master Regulator of Cancer-Induced Aberrant Myelopoiesis

A. Karolina Palucka, Baylor Institute for Immunology Research, USA
Dendritic Cell Cancer Vaccines

Eduardo M. Sotomayor, Moffitt Cancer Center and Research Institute, USA
Dendritic Cells in Cancer: The Good and the Bad

Short Talk Chosen from Abstracts


Following Session is for Inflammation, Infection and Cancer (X1)

17:00—19:00 Origin of Myeloid Cells in Physiology and Cancer
Registered attendees can view abstracts starting on 02/09/2014

Frederic Geissmann, King's College London, UK
Monocyte Origins and Lineage Tracing

Miriam Merad, Mount Sinai Medical Center, USA
Tracing the Cell of Origin for Resident Macrophage Populations

Mikael J. Pittet, Massachusetts General Hospital, USA
Origins of Tumor-Associated Myeloid Cells

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 3

THURSDAY, MARCH 13

07:00—08:00 Breakfast

08:00—11:00 Overcoming Immune Suppression in the Tumor Microenvironment
Registered attendees can view abstracts starting on 02/09/2014

Martin Oft, Targenics, Inc., USA
Killing from Within: How to Activate Tumor Resident Cytotoxic T Cells

George Coukos, University of Pennsylvania, USA
Immune Escape and Angiogenesis

Thomas Blankenstein, Max Delbruck Center for Molecular Medicine, Germany
Oncogene Targeting T Cells

Suzanne L. Topalian, Johns Hopkins University School of Medicine, USA
Counteracting Immune Suppressive Molecules Facilitates the Development of Antitumor Immunity

Short Talk(s) Chosen from Abstracts


Following Session is for Inflammation, Infection and Cancer (X1)

08:00—11:00 Inflammation as a Target and Modulator of Cancer Therapeutics
Registered attendees can view abstracts starting on 02/09/2014

Michael Karin, University of California, San Diego, USA
Talk Title to be Determined

J. Martin Brown, Stanford University, USA
Myeloid Cells and the Adaptive Response to Irradiation

Michele De Palma, Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland
Targeting Myeloid Cell Rebound following Anti-Cancer Therapies

Napoleone Ferrara, University of California, San Diego, USA
Myeloid Cells and VEGF-Independent Tumor Angiogenesis

Short Talk(s) Chosen from Abstracts

09:20—09:40 Coffee Break

On Own for Lunch and Recreation

14:30—16:30 Workshop

Short Talks Chosen from Abstracts

16:30—17:00 Coffee Available

17:00—19:15 Therapeutic Manipulation of the Tumor Microenvironment (Joint)
Registered attendees can view abstracts starting on 02/09/2014

Robert H. Vonderheide, University of Pennsylvania School of Medicine, USA
Enhancing Antigen Presentation

Giorgio Trinchieri, NCI, National Institutes of Health, USA
Inflammation Role in Carcinogenesis and Response to Cancer Therapy

Frances R. Balkwill, Barts Cancer Institute, Queen Mary, University of London, UK
Targeting Inflammatory Cytokines and Chemokines

Carl H. June, University of Pennsylvania, USA
Adoptive Therapy with Engineered T Cells

19:15—20:15 Social Hour w/ Lite Bites

20:00—23:00 Entertainment

FRIDAY, MARCH 14

Departure

9 Mar - 14 Mar 2014
Whistler
Canada
meeting website