Advances in protein-protein interaction analysis and modulation

Protein-protein interactions play a central role in the regulation of all biological processes and represent a promising class of therapeutic targets. Methodological and conceptual advances are required to chart comprehensive protein interaction maps, apprehend the complexity of interaction networks, discover modulators of protein interactions, circumscribe focused chemical spaces.

The workshop aims at bringing together experts from various fields who work on understanding and modulating protein-protein interactions.
The past decade has seen spectacular developments in the field of protein-protein interactions (PPIs). Well-established methods (based on yeast two-hybrid or mass spectrometry) have been performed at (sub-) proteomic scales in a number of model organisms and in human to produce protein interaction maps (interactomes).

Network science concepts and tools have been applied to apprehend the complexity of these interactomes and try to unveil topological and functional properties. The integration of ineractomics, genomics and structural genomics data has enabled first inventories of sequence motifs and structural folds involved in molecular recognition.

Protein interactions, which have generally been considered as undruggable by the pharmaceutical industry, have emerged as a promising class of therapeutic targets.

The growing list of small-molecule inhibitors of protein interactions and structures of protein complexes has allowed first efforts in circumscribing focused chemical spaces and in predicting the druggability of protein interactions.

These recent developments will be presented by 22 invited speakers, 40 posters and a few short talks selected from the submitted abstracts.

The broad scope of the workshop should provide a stimulating outlook of upcoming methodological and conceptual evolutions that will allow to complete protein interaction maps, gain deeper knowledge from interactome data, identify new therapeutic targets, discover vast collections of protein interaction modulators for research and therapeutic purposes.

Topics will include:

■Methodological developments to discover and analyze PPIs
■Discovery of small-molecule modulators of PPIs
■Analysis and exploitation of protein interaction networks
■Chemoinformatics & modeling to define PPI-focused chemical spaces and predict PPI druggability


+ show speakers and program
Thorsten
BERG
Institute of Organic Chemistry, University of Leipzig
Germany

Roger
BRENT
Fred Hutchinson Cancer Research Center, Seattle
USA

Monica
CAMPILLOS
Institute of Bioinformatics and Systems Biology / MIPS
Germany

Jacqueline
CHERFILS
CNRS - Laboratoire d’Enzymologie et Biochimie Structurales, Gif-sur-Yvette
France

Piona
DARIAVACH
Institut de Recherche en Cancérologie de Montpellier
France

Anne-Claude
GAVIN
EMBL Heidelberg
Germany

Toby
GIBSON
EMBL Heidelberg
Germany

Matthias
GSTAIGER
Institute of Molecular Systems Biology, Zurich
Switzerland

Ted
HUPP
Edinburgh Cancer Research UK Centre
UK

Walter
KOLCH
Conway Institute, University College Dublin
Ireland

Lydie
LANE
SIB-Swiss Institute of Bioinformatics
Switzerland

Vincent
LOTTEAU
INSERM – Université Claude Bernard, Lyon
France

Xavier
MORELLI
CNRS- Institut de Microbiologie de la Méditerranée
France

John P.
OVERINGTON
EMBL-EBI, Hinxton
UK

Robert
RUSSELL
BioQuant, Universität Heidelberg
Germany

Luis
SERRANO
CRB-Center for Genomics Regulation, Barcelona
Spain

Olivier
SPERANDIO
INSERM- Université Paris Diderot
France

Jan
TAVERNIER
VIB, Gent
Belgium

Mike
TYERS
Wellcome Trust Center for Cell Biology, Edinburgh
UK

Chandra
VERMA
Bioinformatics Institute, A*STAR
Singapore

Pascale
ZIMMERMANN
Katholieke Universiteit Leuven
Belgium


6 Jun - 9 Jun 2012
Roscoff
France
meeting website