Mobile Genetic Elements and Genome Evolution

Transposable elements are powerful engines of evolution. They constitute the majority of genomic DNA in many eukaryotes, and they dramatically shape genetic content by causing mutations, rearrangements and sequence duplications. Of increasing significance is the link of these transposon-mediated mutations to disease. Sequencing of human populations demonstrates that active transposons are substantially more prevalent than previously appreciated. The aims of this conference are to: 1. Apply recent innovations in high throughput sequencing and genome analysis to the study of transposon biology and genome evolution. 2. Discuss the discovery of cellular systems that inhibit transposon activity as examples of the evolutionary arms race that exists between mobile DNA and their hosts. 3. Describe active transposition during neurogenesis and in tumor cells and raise fundamental questions about the role of mobile DNA in brain development and cancer. This symposium is designed to foster ties between leaders in the field of transposon biology with the pioneers of genome analysis. Discussions of transposon activity and genome evolution will focus on mechanistic models. Methods applied to these problems will include molecular structures, biochemistry, expression studies, and bioinformatic analyses. The transposons and hosts represented in this meeting include diverse examples from eubacteria, archaea, protists, plants, and mammals.
+ show speakers and program
SUNDAY, MARCH 9

16:00—20:00 Arrival and Registration

MONDAY, MARCH 10

07:00—08:00 Breakfast

08:00—10:00 Keynote Session
Registered attendees can view abstracts starting on 02/09/2014

David Botstein, Princeton University, USA
Integrative Genomics

Haig H. Kazazian, Johns Hopkins University School of Medicine, USA
L1 and Mammalian Genome Structure

10:00—10:20 Coffee Break

10:20—11:30 Transposon Applications and Human Health
Registered attendees can view abstracts starting on 02/09/2014

Frederic D. Bushman, University of Pennsylvania, USA
Viral Metagenomes

Kevin L. Gunderson, Illumina, Inc., USA
In vitro Transposition Assays for Next Generation Sequencing Sample Preparation

Short Talk(s) Chosen from Abstracts

11:30—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

16:30—17:00 Coffee Available

17:00—19:00 A Transposon-Eye View of Primate Evolution
Registered attendees can view abstracts starting on 02/09/2014

Mark A. Batzer, Louisiana State University, USA
Mobile Elements and Genomic Variation

Geoffrey J. Faulkner, Mater Medical Research Institute, Australia
L1 Mobilization in Mammalian Somatic Cells

John V. Moran, University of Michigan Medical School, USA
L1 Mechanism

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 1


TUESDAY, MARCH 11

07:00—08:00 Breakfast

08:00—11:00 Mechanisms of Genome Evolution I
Registered attendees can view abstracts starting on 02/09/2014

Marlene Belfort, University of Albany, SUNY, USA
Self-Splicing Introns and Inteins in Genome Evolution

Lynne E. Maquat, Rochester University School of Medicine and Dentistry, USA
Control of Gene Expression via SINE-Containing lncRNAs

Kazufumi Mochizuki, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Austria
Programmed DNA Elimination

Guillaume Bourque, McGill University, Canada
The Role of Genomic Repeats in Host Gene Regulation

Short Talk(s) Chosen from Abstracts

09:20—09:40 Coffee Break

11:00—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

14:30—16:30 Workshop 1

Short Talks Chosen from Abstracts

16:30—17:00 Coffee Available

17:00—19:00 Mechanisms of Genome Evolution II
Registered attendees can view abstracts starting on 02/09/2014

Cedric Feschotte, University of Utah, USA
Evolution of the Bat Genome

David M. Kingsley, Stanford University, USA
Stickleback Genome Evolution

Susan R. Wessler, University of California, Riverside, USA
Strategies of Successful Transposable Elements that Rapidly Diversify Genomes

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 2


WEDNESDAY, MARCH 12

07:00—08:00 Breakfast

08:00—11:00 The Contribution of Host Factors to DNA Mobility
Registered attendees can view abstracts starting on 02/09/2014

Jef D. Boeke, Johns Hopkins University School of Medicine, USA
Revisiting the Cell Biology of Retrotransposition

Nancy L. Craig, HHMI/Johns Hopkins University School of Medicine, USA
Host Factors and DNA Transposons

Alan N. Engelman, Dana-Farber Cancer Institute, USA
Integrase and HIV DNA Integration

Suzanne B. Sandmeyer, University of California, Irvine, USA
Coordinating Retrotransposition with Cellular Programs

Short Talk(s) Chosen from Abstracts

09:20—09:40 Coffee Break

11:00—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

16:30—17:00 Coffee Available

17:00—19:00 The Biological Impact of Mobile DNA, Friend or Foe I
Registered attendees can view abstracts starting on 02/09/2014

Shiv I. S. Grewal, NCI, National Institutes of Health, USA
Specialized Machinery Triggers RNAi to Silence Developmental Genes and Retrotransposons

Henry L. Levin, National Institutes of Health, USA
Biological Impact of Mobile DNA

Damon R. Lisch, University of California, Berkeley, USA
Epigenetic Regulation in Maize

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 3


THURSDAY, MARCH 13

07:00—08:00 Breakfast

08:00—11:00 The Biological Impact of Mobile DNA, Friend or Foe II
Registered attendees can view abstracts starting on 02/09/2014

William Theurkauf, University of Massachusetts Medical Center, USA
Talk Title to be Determined

Harmit Singh Malik, Fred Hutchinson Cancer Research Center, USA
Genetic Conflicts between Host and Viral Genomes

Luciano Marraffini, Rockefeller University, USA
CRISPR-Cas: The Adaptive Immune System of Bacteria and Archaea

Short Talk(s) Chosen from Abstracts

09:20—09:40 Coffee Break

On Own for Lunch and Recreation

14:30—16:30 Workshop 2

Short Talks Chosen from Abstracts

16:30—17:00 Coffee Available

17:00—19:00 The Interface between Mobile DNA, DNA Replication and DNA Repair/The Molecular Face of Transposition
Registered attendees can view abstracts starting on 02/09/2014

Rasika M. Harshey, University of Texas at Austin, USA
My Insertion and DNA Repair

Joseph E. Peters, Cornell University, USA
Vulnerability of DNA Replication on the Lagging-Strand Template to Transposition

Fred Dyda, National Institutes of Health, USA
Transposase Structure and Function

Phoebe A. Rice, University of Chicago, USA
Structure of Mu Transpososome

Short Talk Chosen from Abstracts

20:00—21:00 Social Hour w/ Lite Bites

20:00—23:00 Entertainment

FRIDAY, MARCH 14

Departure

9 Mar - 14 Mar 2014
Santa Fe
United States of America
meeting website