Cilia, Development and Human Disease

Our understanding of the cilium and ciliary-based signaling continue to rapidly advance, providing novel insights into diseases in which ciliary defects appear to play a dominant role in disease initiation ("ciliopathies"), as well as diseases such as cancer in which ciliary defects appear to play a critical role in disease progression. Increasingly, an understanding of ciliary disease mechanisms is leading to novel therapeutic strategies. This Symposium will bring together leaders in basic mechanisms, translational research, and clinical research, with the objective of bridging the gaps between basic discovery and human disease.
+ show speakers and program
SUNDAY, MARCH 2

16:00—20:00 Arrival and Registration

MONDAY, MARCH 3

07:00—08:00 Breakfast

08:00—09:00 Keynote Address
Registered attendees can view abstracts starting on 02/02/2014

Kathryn V. Anderson, Memorial Sloan-Kettering Cancer Center, USA

09:00—11:15 Ciliary Structure, Formation and Resorption
Registered attendees can view abstracts starting on 02/02/2014

Wallace Marshall, University of California, San Francisco, USA
Exploring the Ciliary Length Control System

Paul Lefebvre, University of Minnesota, USA
Molecular Genetics of Ciliary Length Control: The Long Mutants

Speaker to be Announced

Short Talk(s) Chosen from Abstracts

09:40—10:00 Coffee Break

11:15—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

16:30—17:00 Coffee Available

17:00—19:00 Left-Right Patterning and Hedgehog Signaling
Registered attendees can view abstracts starting on 02/02/2014

Bradley K. Yoder, University of Alabama, Birmingham, USA
Cilia in Development and Disease

Yingzi Yang, National Human Genome Research Institute, USA
Planar Cell Polarity of Node Cells and Symmetry Breaking

Hiroshi Hamada, Osaka University, Japan
Planar Polarization of Node Cells and Symmetry Breaking

Short Talk Chosen from Abstracts

19:00—20:00 Dinner

19:30—22:00 Poster Session 1

20:00—21:00 Social Hour

TUESDAY, MARCH 4

07:00—08:00 Breakfast

08:00—11:00 Vesicle Transport and Trafficking
Registered attendees can view abstracts starting on 02/02/2014

Peter K. Jackson, Stanford University, USA
Organizing GPCR Signaling in Primary Cilia

Oliver Blacque, University College Dublin, Ireland
Membrane Trafficking to C. elegans Sensory Cilia

Gregory Pazour, University of Massachusetts Medical School, USA
IFT Polysomes Involved in Vesicle Transport from Golgi to the Ciliary Membrane

Short Talk(s) Chosen from Abstracts

09:20—09:40 Coffee Break

11:00—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

16:30—17:00 Coffee Available

17:00—19:00 Therapeutic Advances in Treating Ciliopathies
Registered attendees can view abstracts starting on 02/02/2014

Jean Bennett, University of Pennsylvania, USA
Gene Transfer for Leber's Congenital Amaurosis

Speaker to be Announced

Frederic J. de Sauvage, Genentech, Inc., USA
Therapeutic Targeting of Hedgehog Signaling

Short Talk Chosen from Abstracts

19:00—20:00 Dinner

19:30—22:00 Poster Session 2

20:00—21:00 Social Hour

WEDNESDAY, MARCH 5

07:00—08:00 Breakfast

08:00—11:00 Cilia, Proliferation and Cancer
Registered attendees can view abstracts starting on 02/02/2014

Elizabeth Petri Henske, Brigham and Women's Hospital, USA
Cilia and the Pathogenesis of Tuberous Sclerosis Complex

Jeremy F. Reiter, University of California, San Francisco, USA
Cilia and Hedgehog-Signaling Dependent Tumorigenesis

Brian Dynlacht, New York University School of Medicine, USA
Basal Body and Centriole Transitions during Oncogenic Transformation

Erica A. Golemis, Fox Chase Cancer Center, USA
Regulation of Ciliary Resorption

Short Talk(s) Chosen from Abstracts

09:20—09:40 Coffee Break

11:00—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

16:30—17:00 Coffee Available

17:00—19:00 Cystic Disease
Registered attendees can view abstracts starting on 02/02/2014

Friedhelm Hildebrandt, University of Michigan, USA
DNA Damage Response Signaling in Ciliopathies

Michael Caplan, Yale University, USA
New Signaling Pathways in Polycystic Kidney Disease

Kimberly M. McDermott, University of Arizona, USA
The Role of Primary Cilia in Cancer Progression and Therapeutics with a Focus on Hedgehog

Short Talk Chosen from Abstracts

19:00—20:00 Dinner

19:30—22:00 Poster Session 3

20:00—21:00 Social Hour

THURSDAY, MARCH 6

07:00—08:00 Breakfast

08:00—11:00 Signaling to and from the Cilium
Registered attendees can view abstracts starting on 02/02/2014

Joel Rosenbaum, Yale University, USA
Exosomes and Signaling from the Cilium

Joseph G. Gleeson, University of California, San Diego, USA
Ahi1, Signaling and Cerebellar Development

Adrian Salic, Harvard Medical School, USA
Hedgehog Signal Transduction in the Primary Cilium

Philip A. Beachy, HHMI/Stanford University, USA
Biochemical Analyses of Hedgehog Signaling

Short Talk(s) Chosen from Abstracts

09:00—09:20 Coffee Break

On Own for Lunch and Recreation

16:30—17:00 Coffee Available

17:00—19:00 Protein Localization to Cilia
Registered attendees can view abstracts starting on 02/02/2014

Michel R. Leroux, Simon Fraser University, Canada
Formation and Function of the Ciliary Gate

Kristen Verhey, University of Michigan, USA
KIF17 and Ciliary Entry

Speaker to be Announced

Short Talk Chosen from Abstracts

19:00—20:00 Dinner

19:00—20:00 Social Hour

20:00—23:00 Entertainment


FRIDAY, MARCH 7

Departure

2 Mar - 7 Mar 2014
Tahoe City
United States of America
meeting website