The Chemistry and Biology of Cell Death

Cell death can occur through distinct mechanisms, and the signaling pathways leading to these lethal outcomes are becoming established. Although therapeutic strategies targeting specific cell death mediators were introduced over 10 years ago, the breadth of cell death mechanisms should present numerous additional possibilities for drug development. To better understand the Achilles’ heels for targeted therapy we need to comprehend the chemistry behind cell death paradigms. We propose that coupling the breadth of chemical biology with genetic analysis of cell death pathways in model organisms will provide not only a comprehensive understanding, but reveal tractable targets. The 2014 Keystone Symposia meeting on The Chemistry and Biology of Cell Death will address the normal regulation and pathogenic dysfunction of distinct cell death modalities, present updates on clinical trials and new strategies for therapeutic intervention, and highlight chemical biology efforts that are leading to a better understanding of the role that cell death plays in health and disease.
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TUESDAY, FEBRUARY 18

16:00—20:00 Arrival and Registration

WEDNESDAY, FEBRUARY 19

07:00—08:00 Breakfast

08:00—10:00 Keynote Session (Joint)
Registered attendees can view abstracts starting on 01/18/2014

Vishva M. Dixit, Genentech, Inc., USA
Signaling Lessons from Death Receptors: The Inflammasome and Beyond

Jodi Nunnari, University of California, Davis, USA
Molecular Basis of Mitochondrial Behaviors

10:00—10:20 Coffee Break

10:20—12:00 Mitochondria and Death (Joint)
Registered attendees can view abstracts starting on 01/18/2014

David W. Andrews, University of Toronto, Canada
Shedding Light on the Mechanisms of Action of Bcl-2 Family Proteins

Richard J. Youle, NINDS, National Institutes of Health, USA
Mitochondrial Quality Control

C. Glenn Begley, Tetralogic Pharmaceuticals, USA
Raising the Standards for Pre-Clinical Research

12:00—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

16:30—17:00 Coffee Available

17:00—19:00 Fundamental Death Mechanisms
Registered attendees can view abstracts starting on 01/18/2014

Douglas R. Green, St. Jude Children's Research Hospital, USA
Non-Apoptotic Developmental Cell Death

Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia
Death Receptors

Seamus J. Martin, Trinity College Dublin, Ireland
Crosstalk between Cell Death and Inflammatory Signaling

Short Talk Chosen from Abstracts


Following Session is for Mitochondrial Dynamics and Physiology (Q5)

17:00—19:00 Mitochondrial Architecture
Registered attendees can view abstracts starting on 01/18/2014

Nikolaus Pfanner, University of Freiburg, Germany
Biogenesis and Architecture of Mitochondria

Thomas Langer, University of Koeln, Germany
Mitochondrial Lipid Trafficking and Organelle Dynamics

Peter Rehling, Göttingen University Medical School, Germany
Mitochondrial Membrane Organization and Protein Biogenesis

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 1

THURSDAY, FEBRUARY 20

07:00—08:00 Breakfast

08:00—11:00 Chemical Biology
Registered attendees can view abstracts starting on 01/18/2014

Mark Hampton, University of Otago, New Zealand
Reactive Oxygen Species and Cell Death

Brent R. Stockwell, Columbia University, USA
Identifying Druggable Disease-Modifying Gene Products

Matthew S. Bogyo, Stanford University School of Medicine, USA
Advances in the Use of Small Molecule Probes to Study Caspase Function

Xiaoguang Lei, National Institute of Biological Sciences (NIBS), China
Probing Necroptosis With Small Molecules

Short Talk(s) Chosen from Abstracts


Following Session is for Mitochondrial Dynamics and Physiology (Q5)

08:00—11:00 Mitochondrial Dynamics
Registered attendees can view abstracts starting on 01/18/2014

Heidi M. McBride, McGill University, Canada
Mitochondrial SUMOylation Links Dynamics to Physiology

Gia K. Voeltz, University of Colorado, Boulder, USA
3D Structures of ER-Mitochondrial Contact Sites in Mammalian Cells

Luca Scorrano, University of Padova, Italy
Role of Mitochondrial Dynamics in Embryogenesis

Stefan Strack, University of Iowa, USA
Regulation of Drp1 Assembly and Mitochondrial Fission

Short Talk(s) Chosen from Abstracts

09:20—09:40 Coffee Break

11:00—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

14:30—16:30 Workshop 1

Short Talks Chosen from Abstracts


Following Session is for Mitochondrial Dynamics and Physiology (Q5)

14:30—16:30 Workshop 1: Mitochondrial Research and Drug Discovery

Short Talks Chosen from Abstracts

16:30—17:00 Coffee Available

17:00—19:00 "Deathomics"
Registered attendees can view abstracts starting on 01/18/2014

James A. Wells, University of California, San Francisco, USA
Caspase Kinetics

Jennie R. Lill, Genentech, Inc., USA
Caspase Substrate Discovery

Harris G. Fienberg, Stanford University, USA
Mass Cytometry in TRAIL Signaling

Short Talk Chosen from Abstracts


Following Session is for Mitochondrial Dynamics and Physiology (Q5)

17:00—19:00 Mitochondria as Signaling Platform
Registered attendees can view abstracts starting on 01/18/2014

Marcia C. Haigis, Harvard Medical School, USA
Sirtuin Regulation of Mitochondria: Energy Production, Apoptosis, and Signaling

Zhijian 'James' Chen, HHMI/University of Texas Southwestern Medical Center, USA
MAVS: A Marvelous Mitochondrial Antiviral Signaling Protein

David C. Chan†, California Institute of Technology, USA
Talk Title to be Determined

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 2

FRIDAY, FEBRUARY 21

07:00—08:00 Breakfast

08:00—11:00 Post-Translational Control of Cell Death
Registered attendees can view abstracts starting on 01/18/2014

John Silke, Walter and Eliza Hall Institute of Medical Research, Australia
IAPs and Ubiquitin

Henning Walczak, Imperial College London, UK
Death Receptors and Ubiquitin in Cell Death and Inflammation

Guy S. Salvesen, Sanford-Burnham Medical Research Institute, USA
Proteolytic Crosstalk in Death and Survival

Marion MacFarlane, MRC Toxicology Unit, UK
Death Receptor Mechanisms

Short Talk(s) Chosen from Abstracts


Following Session is for Mitochondrial Dynamics and Physiology (Q5)

08:00—11:00 Quality Control
Registered attendees can view abstracts starting on 01/18/2014

Cole M. Haynes, Memorial Sloan-Kettering Cancer Center, USA
Repairing and Rebuilding Defective Mitochondria

Jared Rutter, University of Utah, USA
Mitochondrial Ubiquitome and Organelle Turnover

Dario C. Altieri, Wistar Institute, USA
Mitochondrial Chaperones

Koji Okamoto, Osaka University, Japan
Targeting Autophagy for Mitochondrial Clearance

Short Talk(s) Chosen from Abstracts

09:20—09:40 Coffee Break

11:00—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

14:30—16:30 Workshop 2

Short Talks Chosen from Abstracts

16:30—17:00 Coffee Available

17:00—19:00 Death Meets Survival
Registered attendees can view abstracts starting on 01/18/2014

Pamela M. Holland, Amgen Inc., USA
Death Receptor Agonists for Cancer: What's the Right TRAIL?

Marion Bonnet, INSERM U976-Hopital St-Louis, France
Keratinocyte Survival and Death

Kim Newton, Genentech, USA
RIP Kinases

Short Talk(s) Chosen from Abstracts


Following Session is for Mitochondrial Dynamics and Physiology (Q5)

17:00—19:00 Stem Cells and Development
Registered attendees can view abstracts starting on 01/18/2014

Jahar Bhattacharya, College of Physicians & Surgeons, Columbia University, USA
Mitochondrial Transfer from Bone-Marrow-Derived Stromal Cells to Pulmonary Alveoli Protects Against Acute Lung Injury

Carla Koehler, University of California, Los Angeles, USA
Correcting Human Mitochondrial Mutations with Targeted RNA Import

Michael A. Frohman, Stony Brook University, USA
Roles for the Lipid-Signaling Enzyme MitoPLD in Mitochondrial Dynamics, piRNA Biogenesis, and Spermatogenesis

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 3

SATURDAY, FEBRUARY 22

07:00—08:00 Breakfast

08:00—11:00 Leveraging Model Organisms
Registered attendees can view abstracts starting on 01/18/2014

Eli Arama, Weizmann Institute of Science, Israel
Sperm Individualization

Hyung Don Ryoo, New York University School of Medicine, USA
Regulating the Subcellular Distribution of Pro-Apoptotic Proteins

Kim McCall, Boston University, USA
Cell Death in Drosophila Oogenesis

Eric H. Baehrecke, University of Massachusetts Medical School, USA
Cell Death and Autophagy

Short Talk(s) Chosen from Abstracts


Following Session is for Mitochondrial Dynamics and Physiology (Q5)

08:00—11:00 Environmental Control of Mitochondrial Physiology
Registered attendees can view abstracts starting on 01/18/2014

Andrew G. Dillin†, University of California, Berkeley, USA
Epigenetic Switches in the Regulation of Longevity and ETC Function in Worms

Lluis Fajas, Université de Lausanne, Switzerland
Cdk4: A New Actor in Mitochondria Physiology

Erika L. Pearce, Washington University School of Medicine, USA
Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

Christian Frezza, Hutchison/MRC Research Centre, UK
Altered Mitochondrial Metabolism in Cancer

Short Talk(s) Chosen from Abstracts

09:20—09:40 Coffee Break

On Own for Lunch and Recreation


Following Session is for Mitochondrial Dynamics and Physiology (Q5)

14:30—16:30 Workshop 2: Emerging Topics in Mitochondrial Dynamics and Physiology

Short Talks Chosen from Abstracts

16:30—17:00 Coffee Available

17:00—19:00 Systems Biology and Death Imaging
Registered attendees can view abstracts starting on 01/18/2014

Sweeney Ballroom A-B
Peter Sorger, Harvard Medical School, USA
Measuring and Modeling Receptor Mediated Cell Death

Sally A. Kornbluth, Duke University Medical Center, USA
Control of Death by Phosphorylation

Pascal Meier, Institute of Cancer Research, UK
Ripoptosomes

Short Talk Chosen from Abstracts


Following Session is for Mitochondrial Dynamics and Physiology (Q5)

17:00—19:00 Mitochondria in Tissue Homeostasis
Registered attendees can view abstracts starting on 01/18/2014

Eric A. Shoubridge, Montreal Neurological Institute, Canada
Tissue Specificity of Mitochondrial Disorders

Rodrigue Rossignol, University of Bordeaux, France
Metabolic, Transcriptional and Translational Response to Glucose Starvation

Judith Favier†, René Descartes University, France
Complex II and Epigenetics and Cancer

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

20:00—23:00 Entertainment

SUNDAY, FEBRUARY 23

Departure

18 Feb - 23 Feb 2014
Santa Fe
United States of America
meeting website