The NF-kappaB System in Health and Disease

The NF-kappaB System plays key roles in diverse physiological and pathological processes, involving innate and adaptive immunity, and many organs and cell types. The family of NF-kappaB transcription factors have overlapping and specific functions, and are regulated through numerous interconnected molecular mechanisms. The NF-kappaB System refers to the gene regulatory and signal regulatory networks (GRNs and SRNs), within which NF-kappaB transcription factors exert their activities. Those regulatory networks include mitogen-activated kinases, caspases and other apoptotic and necroptotic regulators, regulators of autophagy, cytoskeletal organization, and proliferation, as well as the interferon-regulatory innate immune network. Indeed understanding these processes as an interconnected system is paramount to studies of disease, as manifested by complex immunological, inflammatory, and tumor pathologies. To address these complexities and move towards a predictive understanding, this conference will emphasize the consideration of regulatory interactions, quantitative measurements, in silico modeling, and genome scale studies. It will provide an overview of the field and catalyze scientific interactions in the age of Systems Biology to advance post-genomic Immunology.
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SUNDAY, FEBRUARY 23

16:00—20:00 Arrival and Registration

MONDAY, FEBRUARY 24

07:00—08:00 Breakfast

08:00—09:00 Keynote Address
Registered attendees can view abstracts starting on 01/23/2014

David Baltimore, California Institute of Technology, USA
NFkappaB within Cellular Regulatory Systems

09:00—11:15 NFkappaB within Gene Regulatory Networks
Registered attendees can view abstracts starting on 01/23/2014

NOTE: The function of NFkB transcription factors within the gene regulatory networks, and the mechanisms that mediate stimulus-specific and cell-type specific gene expression programs.

Andrea Califano, Columbia University, USA
Network Biology of Cancer

Aviv Regev, Massachusetts Institute of Technology, USA
Systems Biology of Inflammatory Gene Expression

Irina A. Udalova, University of Oxford, UK
The Specificity of the NFkappaB Dimer Family

Short Talk(s) Chosen from Abstracts

09:40—10:00 Coffee Break

11:15—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

14:30—16:30 Workshop 1 for Highly Innovative, Recent Studies to be Presented

Short Talks Chosen from Abstracts

16:30—17:00 Coffee Available

17:00—19:00 NFkappaB Signaling System
Registered attendees can view abstracts starting on 01/23/2014

NOTE: The NFkB signaling system consists of more than a dozen dimers controlled by several IkB activities. Understanding how cell-type-specific and stimulus-specific control is achieved remains a challenge.

Elizabeth A. Komives, University of California, San Diego, USA
IkappaB Control of NFkappaB Activation and Inactivation

Jana Wolf, Max-Delbrück-Centrum für Molekulare Medizin, Germany
Mathematical Modeling of Regulatory Modules in NF-kappaB Signaling

Gourisankar Ghosh, University of California, San Diego, USA
NF-kappaB Signaling: Lessons from Structural Studies

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 1


TUESDAY, FEBRUARY 25

07:00—08:00 Breakfast

08:00—11:00 The Inflammatory Signaling Network
Registered attendees can view abstracts starting on 01/23/2014

NOTE: NFkB is one of several signaling systems within a larger network that controls inflammation. Understanding how signaling systems are coordinated remains an important challenge.

Vishva M. Dixit, Genentech, Inc., USA
Role of RIP Kinases in NF-kappaB Activation and Necropotsis

Richard A. Flavell, Yale University School of Medicine, USA
Inflammasome-Mediated Dysbiosis Regulates Progression of NAFLD and Obesity

Sarah Spiegel, Virginia Commonwealth University School of Medicine, USA
Phospho-Lipid Signaling Mediators in Inflammatory Signaling

Averil I. Ma, University of California, San Francisco, USA
Attenuating Inflammation with Deubiquitinases

Short Talk(s) Chosen from Abstracts

09:20—09:40 Coffee Break

11:00—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

16:30—17:00 Coffee Available

17:00—19:00 Innate Immune Signaling Networks
Registered attendees can view abstracts starting on 01/23/2014

NOTE: NFkB plays a critical role in innate immune responses when coordinated with other signaling systems. Understanding the molecular mechanisms and systems properties of the innate immune signaling networks remains an important challenge.

Takashi Fujita, Institute for Virus Research, Kyoto University, Japan
Virus-Induced Stress Response and NF-kappaB Activation

Zhijian 'James' Chen, HHMI/University of Texas Southwestern Medical Center, USA
Coordinated Activation of NFkappaB and IRF

Gregory M. Barton, University of California, Berkeley, USA
Toll-Like Receptors in Health and Disease

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 2

WEDNESDAY, FEBRUARY 26

07:00—08:00 Breakfast

08:00—11:00 Lymphoid Signaling Systems
Registered attendees can view abstracts starting on 01/23/2014

NOTE: Within lymphoid cells, NFkB plays critical roles in controlling survival and proliferation. Misregulated NFkB is at the root of immunological diseases and malignancies.

Sankar Ghosh, Columbia University, USA
NFkappaB Control in Lymphocytes

Margot Thome, University of Lausanne, Switzerland
MALT1-Dependent Lymphoid Signaling and B-Cell Malignancy

Alexander Hoffmann, University of California, San Diego, USA
NF-kappaB Network Functions to Fine-Tune Lymphocyte Expansion

Robert C. Rickert, Sanford-Burnham Medical Research Institute, USA
Functional Specificity of IKK Complexes in B-Cell Fate Decisions

Short Talk(s) Chosen from Abstracts

09:20—09:40 Coffee Break

11:00—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

16:30—17:00 Coffee Available

17:00—19:00 Cell Decision Systems
Registered attendees can view abstracts starting on 01/23/2014

NOTE: While NFkB's function as a transcription factor.

Andre Levchenko†, Johns Hopkins University, USA
Talk Title to be Determined

Suzanne Gaudet, Dana-Farber Cancer Institute/Harvard Medical School, USA
Measuring, Modeling and Leveraging Cell-to-Cell Variability in Responses to TNF

Shigeki Miyamoto, University of Wisconsin, Madison, USA
Genotoxic NF-kappaB Responses

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 3

THURSDAY, FEBRUARY 27

07:00—08:00 Breakfast

08:00—11:00 Signaling Systems in Cancer
Registered attendees can view abstracts starting on 01/23/2014

NOTE: NFkB has been implicated in the pathogenesis of many cancers. Its precise role seems to be cancer specific and depends on the contextual network.

Michael Karin, University of California, San Diego, USA
NF-kappaB in Solid Tumors

Louis M. Staudt, NCI, National Institutes of Health, USA
Systems Biology of B Cell Malignancies

Riccardo Dalla-Favera, Columbia University, USA
Lymphocytic Cancers

Klaus Rajewsky, Max Delbrück Center for Molecular Medicine, Germany
Mouse Models of NFkappaB's Roles in Cancer

Short Talk(s) Chosen from Abstracts

09:20—09:40 Coffee Break

On Own for Lunch and Recreation

14:30—16:30 Workshop 2 for Highly Innovative, Recent Studies to be Presented

Short Talks Chosen from Abstracts

16:30—17:00 Coffee Available

17:00—19:00 NFkappaB Systems Pharmacology
Registered attendees can view abstracts starting on 01/23/2014

NOTE: The NFkB signaling system is a critical regulator of many processes and hence a significant drug target. However, its functional pleiotropy harbors risks and regulatory buffering mechanisms pose challenges.

Philip Cohen, University of Dundee, UK
The Composition and Regulation of the NEMOsome

Frank Mercurio, BioTheryX, Inc., USA
Targeting NF-kappaB in the Clinic: Embrace the Complexity

Albert S. Baldwin Jr., University of North Carolina School of Medicine, USA
IKK Signaling in Cancer and Disease

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

20:00—23:00 Entertainment


FRIDAY, FEBRUARY 28

Departure

23 Feb - 28 Feb 2014
Keystone
United States of America
meeting website