Long Noncoding RNAs: Marching toward Mechanism


Much of the mammalian genome is transcribed into long non-coding RNAs, but their biological roles -- such as transcriptional regulation via recruitment of histone-modifying enzymes – are only beginning to be discovered. At the same time, bacterial non-coding RNAs are being found to function as small-molecule-sensing riboswitches and as elements of the CRISPR defense system. For all of these biological systems, a key remaining problem is to understand the detailed mechanism of action. Listing and comparing all of the long ncRNAs, riboswitches, and CRISPR elements genome-wide and among species is useful, but how does the RNA function in each of these systems? The goal of this Keystone Symposium is to stimulate conversations between scientists who work on these very diverse RNA systems, so they can share conceptual frameworks and experimental techniques. This goal will be accomplished by convening an exceptional group of academic and industrial scientists and students to share their insights.
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THURSDAY, FEBRUARY 27

16:00—20:00 Arrival and Registration

FRIDAY, FEBRUARY 28

07:00—08:00 Breakfast

08:00—09:00 Keynote Address
Registered attendees can view abstracts starting on 01/27/2014

Phillip A. Sharp, Massachusetts Institute of Technology, USA

09:00—11:15 Epigenetics and ncRNAs
Registered attendees can view abstracts starting on 01/27/2014

Anton Wutz, University of Cambridge, UK
Developmental Regulation of Noncoding RNA Function of the Mouse X Inactivation Center

Jeannie T. Lee, Massachusetts General Hospital, USA
XIST and TSIX in X-Chromosome Inactivation

Denise P. Barlow, Center for Molecular Medicine, Austria
Gene Silencing by Macro LncRNA Transcriptional Interference

Short Talk(s) Chosen from Abstracts

09:40—10:00 Coffee Break

11:15—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

16:30—17:00 Coffee Available

17:00—19:00 ncRNAs and Transcriptional Control
Registered attendees can view abstracts starting on 01/27/2014

Danny F. Reinberg, HHMI/New York University, USA
Histone Modification and Long ncRNAs

Ingrid Grummt, German Cancer Research Center, Germany
rRNA Regulation by ncRNAs

Edith Heard, Institut Curie, France
A New lncRNA

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 1

SATURDAY, MARCH 1

07:00—08:00 Breakfast

08:00—11:00 Bacterial ncRNAs
Registered attendees can view abstracts starting on 01/27/2014

Ronald R. Breaker, Yale University, USA
Large ncRNAs in Bacteria

Gisela T. Storz, NICHD, National Institutes of Health, USA
Bacterial Riboregulators

Pascale Cossart, Institut Pasteur, France
ncRNAs and Bacterial Pathogens, e.g. Listeria

Karen M. Wassarman, University of Wisconsin-Madison, USA
6S RNA

Short Talk(s) Chosen from Abstracts

09:20—09:40 Coffee Break

11:00—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

14:30—16:30 Workshop 1

Short Talks Chosen from Abstracts

16:30—17:00 Coffee Available

17:00—19:00 Riboswitches and CRISPR
Registered attendees can view abstracts starting on 01/27/2014

Jennifer A. Doudna, HHMI/University of California, Berkeley, USA
CRISPRs: Mechanism and Structure

Beatrix Suess, Technical University Darmstadt, Germany
Engineered Riboswitches

Robert T. Batey, University of Colorado, Boulder, USA
Structure and Mechanism of Bacterial Riboswitches

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 2

SUNDAY, MARCH 2

07:00—08:00 Breakfast

08:00—11:00 RNA Methods, Diagnostics and Therapeutics
Registered attendees can view abstracts starting on 01/27/2014

Howard Y. Chang, Stanford University, USA
High-Throughput Analysis of ncRNA Structure and Function

Larry Gold, Somalogic Inc., USA
Nucleic Acid SOMAmers for Diagnostics and Therapeutics

Bruce A. Sullenger, Duke University, USA
Clinical Applications of Antithrombotic Non-Coding RNAs

Arthur M. Krieg, RaNa Therapeutics, USA
Selectively Activating Gene Expression by Targeting PRC2-Associated lncRNAs

Short Talk(s) Chosen from Abstracts

09:20—09:40 Coffee Break

11:00—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

16:30—17:00 Coffee Available

17:00—19:00 Catalytic RNAs and RNPs
Registered attendees can view abstracts starting on 01/27/2014

Anna Marie Pyle, Yale University, USA
The Tertiary Structures of Long Noncoding RNAs: Lessons from Catalytic Introns

Peter Baumann, Stowers Institute for Medical Research, USA
Telomerase Biogenesis and Regulation

Joachim Lingner, École Polytechnique Fédérale de Lausanne (EPFL), Switzerland
Telomere Functions of TERRA ncRNA

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 3

MONDAY, MARCH 3

07:00—08:00 Breakfast

08:00—11:00 Genome-Wide Analysis
Registered attendees can view abstracts starting on 01/27/2014

John L. Rinn, Harvard University, USA
Linking RNA to Cellular Differentiation

Jonathan S. Weissman, University of California, San Francisco, USA
What's on Ribosomes?

Thomas R. Gingeras, Cold Spring Harbor Laboratory, USA
Lessons Learned from Complex Genomes

Caroline Dean, John Innes Centre, UK
Linking Antisense RNA and Chromatin in Flowering Control

Short Talk(s) Chosen from Abstracts

09:20—09:40 Coffee Break

On Own for Lunch and Recreation

14:30—16:30 Workshop 2

Short Talks Chosen from Abstracts

16:30—17:00 Coffee Available

17:00—19:00 Long ncRNAs and Chromatin
Registered attendees can view abstracts starting on 01/27/2014

Speaker to be Announced

Geneviève Almouzni, Centre National de la Recherche Scientifique, France
Satellite Transcripts and Heterochromatin Formation during Development and in Cancer

Thomas R. Cech, HHMI/University of Colorado, USA
FUS/TLS, ncRNAs and RNA Pol II

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

20:00—23:00 Entertainment

TUESDAY, MARCH 4

Departure

27 Feb - 4 Mar 2014
Santa Fe
United States of America
meeting website