Omics Meets Cell Biology: Applications to Human Health and Disease

This conference brings together researchers that are applying and developing novel “Omics” approaches to interrogate system-level networks with an ultimate goal of understanding the functions of proteins of therapeutic importance. The conference will place a special emphasis on the interface between Omics-level sciences as applied to and integrated with classical molecular- and cell-biological studies. Because these large-scale projects involve multidisciplinary teams from both academic and biotech/pharma labs that are situated in different institutions all over the world, this meeting will provide a unique opportunity for diverse research groups to get together and discuss new ideas, approaches, and novel results. SPECIFIC AIMS: This conference will explore how classical approaches to study biological processes, such as those used in cell biology, biochemistry and genetics, intersect with the new “Omics” technologies to advance our understanding of biological pathways associated with various human diseases. Extensive research in the past decade has shown that data sets generated by various “Omics” technologies represent a unique resource for biologists. However, a number of challenging technical and conceptual issues have been identified. These issues and resulting solutions will, ultimately determine their impact on biology and medicine. Some of the issues include completeness and reproducibility of large-scale data sets, and how different data types obtained from the same and different systems can be integrated. Perhaps most importantly, a key objective of the meeting will be to explore the development of simple and robust methods for understanding the meaning of “Omics” data. This in turn will further facilitate the integration and dissemination of the data. MEETING OBJECTIVES: 1. Explore the current status of interfacing “Omics” and molecular and cell biology in general, and specifically in selected areas of research. 2. Explore the current status of computational analysis of data generated by “Omics” technologies with respect to their potential to support both high-throughput and traditional molecular and cell biological research with an emphasis on disease-related projects. 3. Explore emerging “Omics” technologies with respect to their suitability to interface with molecular- and cell-biological research. 4. Provide an interactive forum to involve new investigators and highlight their discoveries.
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Registered attendees can view abstracts starting on 01/18/2014

TUESDAY, FEBRUARY 18

16:00—20:00 Arrival and Registration

WEDNESDAY, FEBRUARY 19

07:00—08:00 Breakfast

08:00—09:00 Keynote Address
Brenda J. Andrews, University of Toronto, Canada
Integrating Omics and Cell Biology: Applications to Global Protein Localization and Flux Maps in Yeast

09:00—11:15 Proteomics Technologies: Applications to Disease

Matthias Selbach, Max Delbrück Center for Molecular Medicine, Germany
From Protein-Protein Interactions to Disease Phenotypes

Anne-Claude Gingras, Samuel Lunenfeld Research Institute, Canada
Signaling Interactome Dynamics in Health and Disease

Ileana M. Cristea, Princeton University, USA
Proteomics Meets Virology

Short Talk(s) Chosen from Abstracts

09:40—10:00 Coffee Break

11:15—13:00 Poster Setup

11:15—12:15 Panel: Industry Options in "Omics": From Technology Development to Applications

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

16:30—17:00 Coffee Available

17:00—19:00 Omics Meets Genetics and Gene Expression

Heng Zhu, Johns Hopkins University School of Medicine, USA
Global Analysis of DNA Methylation-Dependent Transcription Factor-Binding Activity

Michael Snyder, Stanford University School of Medicine, USA
Extensive Dynamic Changes in Omics Profiles during Normal and Disease States

Frank C.P. Holstege, University Medical Center, Utrecht, Netherlands
Validation of a Gene Expression Signature for Assessment of Lymph Node Metastasis in Oral Squamous Cell Carcinoma

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 1

THURSDAY, FEBRUARY 20

07:00—08:00 Breakfast

08:00—11:00 From Genotype and Phenotype

Charlie M. Boone, University of Toronto, Canada
The Genetic Landscape of the Cell

Yoshi Ohya, University of Tokyo, Japan
Chemical Genetic Approaches to Elucidate Complex Cellular Processes

Giulio Superti-Furga, CeMM Center for Molecular Medicine of the Austrian Academy of Sciences, Austria
Charting and Challenging the Molecular Machinery of Human Cells

Short Talks Chosen from Abstracts

09:20—09:40 Coffee Break

11:00—13:00 Poster Setup

11:00—12:00 Panel: Academic Careers in "Omics": Starting Up a Successful Research Program

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

16:30—17:00 Coffee Available

17:00—19:00 Omics Meets Drug Discovery

Stefan Knapp, University of Oxford, UK
Using Structural Proteomics as a Tool for Drug Discovery

Domagoj Vucic, Genentech, Inc., USA
Targeting Ubiquitin Ligases in Cancer and Inflammation

Gerard Drewes, Cellzome - a GSK Company, Germany
Chemical Proteomics of Enzyme Families

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 2

FRIDAY, FEBRUARY 21

07:00—08:00 Breakfast

08:00—11:00 Computational Analysis of Systems Biology

Peer Bork, European Molecular Biology Laboratory, Germany
Systemic Analysis of the Human Gut: Learning from Bugs and Drugs

Nuno Bandeira, University of California, San Diego, USA
Toward Extensive Characterization of all Variation in Proteomics and Beyond

Olga G. Troyanskaya, Princeton University, USA
From Functional Genomics Studies to the Cell-Lineage Specific View of Human Disease

Trey Ideker, University of California, San Diego, USA
Mapping the Genetic Networks of Cancer

Short Talk(s) Chosen from Abstracts

09:20—09:40 Coffee Break

11:00—13:00 Poster Setup

11:00—12:00 Panel: Publishing High Impact "Omics" Papers

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

16:30—17:00 Coffee Available

17:00—19:00 An Integrated View of Cellular Signaling

Tony Pawson, Samuel Lunenfeld Research Institute, Canada
Signaling Networks in Cell Fate Determination

Walter Kolch, University College Dublin, Ireland
Molecular Computing: How Protein Interaction Networks Coordinate Cell Fate Decisions

Igor Stagljar, University of Toronto, Canada
Protein Interaction Networks Regulating Cell Signaling in Human Health and Disease

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 3

SATURDAY, FEBRUARY 22

07:00—08:00 Breakfast

08:00—11:00 Global Analysis of Metabolic and Lipidomics Networks

Markus Ralser, University of Cambridge, UK
Genetic Basis of Stability and Flexibility of Metabolic Networks

Markus R. Wenk, National University of Singapore, Singapore
Natural Variation of Blood Lipids in Healthy Human Individuals with Different Ethnic Backgrounds

A.J. Marian Walhout, University of Massachusetts Medical School, USA
Integrative Network Biology in the Nematode C. elegans

Anne-Claude Gavin, European Molecular Biology Laboratory (EMBL), Germany
Expending the Interaction Space: Protein-Metabolite Networks

Short Talk(s) Chosen from Abstracts

09:20—09:40 Coffee Break

On Own for Lunch and Recreation

16:30—17:00 Coffee Available

17:00—18:45 Omics and Neurodegenerative Disorders

Paola Picotti, ETH Zurich, Switzerland
Probing Generic and Specific Responses to Intracellular Protein Aggregation

Erich E. Wanker, Max Delbrueck Center for Molecular Medicine, Germany
From Protein Interaction Networks to Neurodegenerative Disease Mechanisms

Tony Schapira, University College London, France
The Intersection of Biochemistry and Genomics in Parkinson's Disease Pathogenesis

18:45—19:30 Closing Address
Rudolf H. Aebersold, Institute of Molecular Systems Biology, ETH Zurich, Switzerland
Network Driven Protein Biomarker Discovery and Validation

19:30—20:30 Social Hour w/ Lite Bites

20:00—23:00 Entertainment

SUNDAY, FEBRUARY 23 - Departure






18 Feb - 23 Feb 2014
Taos
United States of America
meeting website