Biology of B Cell Responses

The meeting will provide an overview of the latest advances in research on the biology of B cell responses. The requirements and processes relevant for the induction of protective B cell responses remain in large unclear and inefficient or deregulated B cell responses are frequently associated with the development of diseases. The goal of the meeting is to deepen our understanding of the factors and mechanisms controlling and regulating B cell development, differentiation and activation under steady-state conditions and in autoimmunity, infection, and B cell tumors. The specific aims are: 1. to identify factors involved in the developmental programming and function of B cells, 2. to elucidate the mechanisms relevant for the establishment and maintenance of B cell self-tolerance, 3. to define how B cell responses are initiated and regulated, 4. to provide insight in the mechanisms and dynamics underlying germinal center responses, and 5. to establish the link between immunoglobulin gene diversification and B cell tumor development. The meeting will provide a platform for early stage and established researchers to engage into interactive discussions on all aspects of the biology of B cell responses from B cell evolution to basic principles of B cell biology and human B cell immunology. It will thereby facilitate and booster the exchange of ideas and the initiation of collaborative research on B cells at international level. Interactions will be fostered across disciplines. Access to the parallel Keystone Meeting on Antibodies as Prophylactics and Therapeutic Drugs will provide all attendees with the unique opportunity to engage into expanded interdisciplinary interaction with translational scientists from academia and industry.
+ show speakers and program
Keynote Address
Jason G. Cyster, HHMI/University of California, San Francisco, USA
Lymphocyte Migration

Barry P. Sleckman, Washington University School of Medicine, USA
Pathways of Normal and Aberrant RAG Double Strand Break Repair in Developing B Cells

Cornelis Murre, University of California, San Diego, USA
Global Analysis of Long-Range Genomic Interactions that Orchestrate B Cell Fate

Hassan Jumaa, Max Planck Institute for Immunobiology, Germany
Pre B Cell Development Short Talk(s) Chosen from Abstracts

Christopher C. Goodnow, Australian National University, Australia
B Cell Self-Tolerance

Ann Marshak-Rothstein, University of Massachusetts Medical School, USA
(De-)Regulation of B Cell Activation

Roberta Pelanda, National Jewish Health, USA
Positive and Negative Selection of Primary B Cells

Facundo D. Batista, Cancer Research UK, London Research Institute, UK
Dynamic Imaging of Lymphocyte Activation: From Single Molecule to Living Tissue

Susan K. Pierce, NIAID, National Institutes of Health, USA
B Cell Responses in Malaria

Tomohiro Kurosaki, WPI Immunology Frontier Research Center, Osaka University, Japan
B Cell Differentiation

Jeffrey V. Ravetch, Rockefeller University, USA
Regulating B Cell Activation

Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland
B Cell Memory to Infection

Patrick C. Wilson, University of Chicago, USA
The Human B Cell Response to Viral Infection

Hedda Wardemann, Max-Planck Institute for Infection Biology, Germany
B Cell Selection

Marc K. Jenkins, University of Minnesota Medical School, USA
Origins of CD4+ Memory T Cells

Michael G. McHeyzer-Williams, The Scripps Research Institute, USA
Regulating B Cell Immunity

Carola G. Vinuesa, Australian National University, Australia
Selection of Memory B Cells

Shane Crotty, La Jolla Institute for Allergy and Immunology, USA
T Cell Help to B Cells: Differentiation and Function of Follicular Helper CD4 T Cells (Tfh)

David M. Tarlinton, Walter and Eliza Hall Institute of Medical Research, Australia
B Cell Responses

Mark J. Shlomchik, Yale University School of Medicine, USA
Germinal Center Selection and the Development of Memory B and Plasma Cells

Michel C. Nussenzweig, HHMI/Rockefeller University, USA
Germinal Center Biology

Max D. Cooper, Emory University, USA
Immune System Ontogeny and Phylogeny

David G. Schatz, Yale University School of Medicine, USA
Targeting of V(D)J Recombination and Somatic Hypermutation

Cristina Rada, MRC Laboratory of Molecular Biology, UK
Ig Gene Mutagenesis

Frederick W. Alt, Boston Children's Hospital, USA
Mechanisms of CSR and SHM

Klaus Rajewsky, Max Delbrück Center for Molecular Medicine, Germany
B Cell Immune Regulation

Louis M. Staudt, NCI, National Institutes of Health, USA
Therapies Targeting Pathological Signaling in B Cell Lymphomas

Riccardo Dalla-Favera, Columbia University, USA
Human Germinal Center B Cell Tumors

9 Feb - 14 Feb 2014
Keystone
United States of America
meeting website