Developmental Pathways and Cancer: Wnt, Notch and Hedgehog

Dysregulation of signaling pathways involved in embryogenesis, such as Wnt, Notch and Hedgehog, is a frequent feature of cancers involving adult tissues. Components of these pathways are recurrently mutated in diverse cancers, and increasing evidence points to a role for their ligands in directing cancer cell self-renewal and stromal responses, including angiogenesis, tissue remodeling, and tumor immunity. Extensive efforts to target these pathways are ongoing in academia and industry. Capitalizing on increased understanding of signaling mechanisms and biological roles of these pathways in cancer, major progress have been made recently, and a number of agents are being investigated currently in pre-clinical models or the clinic. The goal of this conference is to bring together experts in all aspects of tumor biology impacted by these developmental pathways, and to discuss the latest advances to help bring these concepts from bench to bedside.
+ show speakers and program
SUNDAY, FEBRUARY 2

16:00—20:00 Arrival and Registration

MONDAY, FEBRUARY 3

07:00—08:00 Breakfast

08:00—11:00 Signaling Mechanisms at the Cell Surface
Registered attendees can view abstracts starting on 01/02/2014

Speaker to be Announced

Xi He, Harvard Medical School, USA
Wnt Signaling Mechanism

Jeremy F. Reiter, University of California, San Francisco, USA
Hh Signaling in Cilia and Cancer

* Raphael Kopan, Washington University, USA
Notch Signaling

Short Talk(s) Chosen from Abstracts


Following Session is for Stem Cells and Cancer (J8)

08:00—11:00 Signaling Pathways in Stem Cells
Registered attendees can view abstracts starting on 01/02/2014

Jürgen A. Knoblich, IMBA - Institute of Molecular Biotechnology, Austria
Asymmetric Division

Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
Methylation in Stem Cells and Cancer

Thea D. Tlsty, University of California, San Francisco, USA
Regulation of Mammary Stem Cells and Plasticity

Geoffrey M. Wahl, The Salk Institute, USA
Signaling in Mammary Stem Cells and Cancer

Short Talk(s) Chosen from Abstracts

09:20—09:40 Coffee Break

11:00—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

16:30—17:00 Coffee Available

17:00—19:00 Signaling Mechanisms and Cancer
Registered attendees can view abstracts starting on 01/02/2014

Adolfo Ferrando, Columbia University, USA
T-ALL Therapeutics

Holger Gerhardt, London Research Institute, UK
Dll4/Notch Dynamics in Vascular Branching

* Warren S. Pear, University of Pennsylvania, USA
Normal and Leukemogenic Roles for Notch in Immune Cells

Short Talk Chosen from Abstracts


Following Session is for Stem Cells and Cancer (J8)

17:00—19:00 Shared Signals in Stem Cells and Cancer
Registered attendees can view abstracts starting on 01/02/2014

Leonard I. Zon, HHMI/Children's Hospital Boston, USA
Stem Cells and Cancer in Model Organisms

Tannishtha Reya, University of California, San Diego, USA
Developmental Signaling in Stem Cells and Cancer

Elaine Fuchs, HHMI/Rockefeller University, USA
Signaling in Skin Stem Cells and Skin Cancer

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 1


TUESDAY, FEBRUARY 4

07:00—08:00 Breakfast

08:00—11:00 Nuclear Responses and Tumorigenesis
Registered attendees can view abstracts starting on 01/02/2014

* Jon C. Aster, Brigham and Women's Hospital, USA
Determinants of Notch Target Gene Activation in Cancer Cells

Stephen C. Blacklow, Dana Farber Cancer Institute, USA
Ligand-Mediated Notch Activation

Mariann Bienz, MRC Laboratory of Molecular Biology, UK
Nuclear Wnt Signaling

Marian Waterman, University of California, Irvine, USA
LEF/TCF Targets and Cancer Metabolism

Short Talk(s) Chosen from Abstracts


Following Session is for Stem Cells and Cancer (J8)

08:00—11:00 Cancer Cell of Origin
Registered attendees can view abstracts starting on 01/02/2014

Scott A. Armstrong, Memorial Sloan-Kettering Cancer Center, USA
Epigenetic Control of Myeloid Leukemia Development

Robert J. Wechsler-Reya, Sanford-Burnham Medical Research Institute, USA
Stem Cells and the Origins of Medulloblastoma

Philip A. Beachy, HHMI/Stanford University, USA
The Cellular Origin of Bladder Neoplasia and Tissue Dynamics of its Progression to Invasive Carcinoma

Luis F. Parada, University of Texas Southwestern Medical Center, USA
Lineage Tracing and the Cancer Initiating Cell in Brain Tumors

Short Talk Chosen from Abstracts

09:20—09:40 Coffee Break

Following Session is for Stem Cells and Cancer (J8)

11:00—12:30 Roundtable: Preclinical Models

* Craig T. Jordan, University of Colorado, Anschutz Medical Campus, USA

Robert S. Kerbel, Sunnybrook Research Institute, Canada
Preclinical Models

11:00—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation

16:30—17:00 Coffee Available

17:00—19:00 Developmental Pathways and Tumor Initiation
Registered attendees can view abstracts starting on 01/02/2014

* Freddy Radtke, EPFL SV ISREC UPRAD, Switzerland
Tumor Suppressive Roles of Notch in Epithelial Cells

Owen J. Sansom, Beatson Institute of Cancer Research, UK
Wnt and mTOR Signaling in the Intestine

Rune C-M. Toftgard, Karolinska Institutet, Sweden
Hedgehog Signaling, Stem Cells and Skin Cancer Initiation

Short Talk Chosen from Abstracts


Following Session is for Stem Cells and Cancer (J8)

17:00—19:00 Cancer Stem Cells
Registered attendees can view abstracts starting on 01/02/2014

Sean J. Morrison, HHMI/University of Texas Southwestern Medical Center, USA
The Regulation of Melanoma Metastasis

John E. Dick, Princess Margaret Cancer Centre, University Health Network, Canada
Leukemia Stem Cells

Jeffrey M. Rosen, Baylor College of Medicine, USA
Tracking and Targeting Breast Cancer Stem Cells

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 2

WEDNESDAY, FEBRUARY 5

07:00—08:00 Breakfast

08:00—11:30 Stem Cells, Development and Cancer (Joint)
Registered attendees can view abstracts starting on 01/02/2014

Cédric Blanpain, Université Libre de Bruxelles, Belgium
Keynote Address: Tumor Stem Cells

Irving L. Weissman, Stanford University School of Medicine, USA
Keynote Address: Re-Engaging the Immune System against Cancer Stem Cells

Richard J. Gilbertson, St. Jude Children's Research Hospital, USA
Matching Therapy with Cancer in Developing Tissues

Roeland Nusse, HHMI/Stanford University, USA
Wnt Signaling in Development and Cancer

Catriona H.M. Jamieson, University of California, San Diego, USA
Therapeutic Targeting of Cancer Stem Cells in Hematologic Malignancies

09:40—10:00 Coffee Break

11:30—13:00 Poster Setup

13:00—22:00 Poster Viewing

On Own for Lunch and Recreation


Following Session is for Stem Cells and Cancer (J8)

14:30—16:30 Workshop

Short Talks Chosen from Abstracts

16:30—17:00 Coffee Available

17:00—19:00 Developmental Pathways in Cancer and Metastasis
Registered attendees can view abstracts starting on 01/02/2014

* Michael D. Taylor, Hospital for Sick Children, Canada
Hh in Medulloblastoma

Kimberly Stegmaier, Dana-Farber Cancer Institute, USA
Targeting Mutated NOTCH1 in Cancer

Joerg Huelsken, EPFL, Switzerland
Wnt-Dependent Metastasis

Short Talk Chosen from Abstracts


Following Session is for Stem Cells and Cancer (J8)

17:00—19:00 Cancer in Context: The Microenvironment and Metastasis
Registered attendees can view abstracts starting on 01/02/2014

Zena Werb, University of California, San Francisco, USA
Imaging the Microenvironment in Mammary Development and Cancer

Jing Yang, University of California, San Diego, USA
Epithelial-Mesenchymal Transition in Tumor Metastasis

Joan Massagué, HHMI/Memorial Sloan-Kettering Cancer Center, USA
Stem Cell Signals in Metastasis

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

19:30—22:00 Poster Session 3

THURSDAY, FEBRUARY 6

07:00—08:00 Breakfast

08:00—11:00 Emerging Cancer Drug Targets in Development Pathways
Registered attendees can view abstracts starting on 01/02/2014

* Richard A. Lang, Cincinnati Children's Hospital Medical Center, USA
Wnt in Angiogenesis

Feng Cong, Novartis Institutes for BioMedical Research, USA
Control of Wnt Signaling by Ubiquitin and Tankyrase

Austin Gurney, OncoMed Pharmaceuticals, USA
Notch/Wnt Inhibitors in Tumor Stem Cells/Angiogenesis

Bradley E. Bernstein, Massachusetts General Hospital, Harvard Medical School, USA
Epigenetic Mechanism of Resistance to GSI

Short Talk(s) Chosen from Abstracts


Following Session is for Stem Cells and Cancer (J8)

08:00—11:00 New Regulatory Pathways in Cancer
Registered attendees can view abstracts starting on 01/02/2014

Charlotte Kuperwasser, Tufts University School of Medicine, New England, USA
Genetic and Epigenetic Plasticity of Stem Cells in Breast Cancer

Lewis A. Chodosh, University of Pennsylvania School of Medicine, USA
Mechanisms Controlling Dormancy and Tumor Recurrence

Vishva M. Dixit, Genentech, Inc., USA
Apoptosis and Cancer

Short Talks Chosen from Abstracts

09:20—09:40 Coffee Break

Following Session is for Stem Cells and Cancer (J8)

11:00—12:30 Roundtable: Early Translation

* Philip A. Beachy, HHMI/Stanford University, USA

On Own for Lunch and Recreation

16:30—17:00 Coffee Available

17:00—19:00 Targeting Developmental Pathways: Clinical Experience
Registered attendees can view abstracts starting on 01/02/2014

Gavin O. Thurston, Regeneron Pharmaceuticals Inc., USA
Dll4 Inhibitor in Tumor Angiogenesis

Jean Y. Tang, Stanford University School of Medicine, USA
Hedgehog Pathway Inhibitor Clinical Trials

* Frederic J. de Sauvage, Genentech, Inc., USA
Innate and Acquired Resistance to Hedgehog Pathways Inhibitors

Short Talk Chosen from Abstracts


Following Session is for Stem Cells and Cancer (J8)

17:00—19:00 Targeting Cancer Stem Cells: Trials and Translation
Registered attendees can view abstracts starting on 01/02/2014

Craig T. Jordan, University of Colorado, Anschutz Medical Campus, USA
Therapeutic Targeting of Leukemia Stem Cells

Jeremy N. Rich, Cleveland Clinic, USA
Brain Tumor Stem Cells and Resistance to Therapy

Michael F. Clarke, Stanford University, USA
Targeting Cancer Stem Cells in Breast Cancer

Short Talk Chosen from Abstracts

19:00—20:00 Social Hour w/ Lite Bites

FRIDAY, FEBRUARY 7

Departure

2 Feb - 7 Feb 2014
Banff
Canada
meeting website