TGF-β Superfamily: Signaling in Development and Disease

TGF-β Superfamily:
Signaling in Development and Disease
+ show speakers and program
Sunday,July, 28, 2013
4:00PM – 9:00PM Conference Registration
6:00PM – 7:00 PM FASEB Opening Reception
7:00PM – 8:30 PM Dinner
Chair: Peter ten Dijke, LUMC, The Netherlands
8:45PM – 10:00PM Keynote Speaker: Hans Clevers, Hubrecht Institute, The Netherlands
Wnt signaling in stem cells and cancer

Monday,July, 29, 2013
7:30AM – 9:00AM Breakfast
Session 1:
9:00AM – 12:30PM
Signaling mechanisms
Chair: Caroline Hill, Cancer Research UK, London Research Institute, UK
9:00AM – 9:15AM Welcome from FASEB
9:15AM - 9:45AM Joan Massagué, Memorial Sloan-Kettering Cancer Center,
New York, USA,
Smads in stem cell regulation
9:45AM –10:15AM Caroline Hill, Cancer Research UK,
London Research Institute, UK
BMP/Smad signaling in development
10:15AM – 10:30 AM Allan Mullen, Whitehead Institute for Biomedical Research, Cambridge, USA
Master transcription factors determine cell-type-specific responses to TGF-β signaling
10:30AM – 11:00AM Group photo & FASEB Sponsored Coffee Break
11:00AM – 11:30AM Alain Mauviel, Institute Curie, INSERM, Paris, France
TGF-β and Hippo signaling pathways in melanoma
11:30AM – 12:00PM Aristidis Moustakas, Ludwig Institute for Cancer Research, Uppsala, Sweden
Regulation of TGFβ signaling by phosphorylation and ADP-ribosylation
12:00PM – 12:30PM Xin-Hua Feng, Baylor College of Medicine, Houston, TX, USA
Phosphatases in growth factor signaling
12:30PM – 1:30PM Lunch
4:00PM – 6:00PM Poster Session 1
6:00PM – 7:00PM Dinner
Session 2: Vertebrate development
7:00PM – 10:15PM Chair: Michael O Connor, University of Minnesota, Minnesota, USA
7:00PM - 7:30PM To be announced.
7:30PM – 8:00PM Kunxin Luo, University of California, Berkeley, USA
SnoN in development and tissue morphogenesis
8:00PM – 8:30PM Anming Meng, University of Minnesota, Minnesota, USA
BMP in dorsoventral patterning of zebrafish embryos
8:30PM – 9.00PM Break
9.00PM – 9.15PM Short Talk Selected From Submitted Abstracts
9.15PM – 9:45PM Elizabeth J. Robertson, Oxford University, Oxford, UK.
Cell fate decisions in the early mouse embryo
9:45PM – 10:15PM Mary Mullins, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
BMP specifies cranial neural crest progenitor cells in zebrafish

Tuesday,July, 30, 2013
7:30AM – 9:00AM Breakfast
Session3 Stem cells and cancer
9:00AM – 12:15PM Chair: Jeff Wrana, Samuel Lunenfeld Institute, Toronto, Canada
9.00AM - 9:30AM Jeff Wrana, Samuel Lunenfeld Institute, Toronto, Canada
Intersection of Hippo and TGF-β signaling
9:30PM –10:00AM Kohei Miyazono, University of Tokyo, Japan
TGF-β in regulation of cancer stem cells
10:00AM – 10:15AM Ye-Guan Chen, Tsinghua University, Beijing, China
Regulation of TGF-β receptor signaling
10:15AM – 10:45AM FASEB Sponsored Coffee Break
10:45AM – 11:15PM Joan Seoane, Vall d'Hebron University Hospital,
Barcelona, Spain
Targeting TGF-β in glioblastoma
11:15PM – 12:00PM Lalage Wakefield, NCI/NIH, Bethesda, USA
Differential roles Smads in breast cancer tumorigenesis
12:00PM – 12:30PM Mary–Helen Barcellos Hoff, New York University School of Medicine, New York, USA
Consequences of epithelial or stromal TGFβ1 depletion in the mammary gland
12:30PM – 1:30PM Lunch
Free Afternoon
4:00PM – 6:00PM “Meet with the expert session”
6:00PM – 7:00PM Dinner
Session 4: Invertebrate development and morphogenesis
7:00PM – 10:00PM Chair: Markus Affolter, Biocenter of University of Basel, Switzerland
7:00PM - 7:30PM Markus Affolter, Biocenter of University of Basel, Switzerland
BMP morphogen signaling
7:30PM – 8:00PM Michael O Connor, University of Minnesota, Minnesota, USA
Regulation of Drosophila tissue growth
8:00PM – 8:15PM Short Talk Selected From Submitted Abstracts
8:15PM – 8:30PM Break
8:30PM – 9:00PM Laurel Raftery, University of Nevada, Las Vegas, USA
BMP signaling in Drosophila
9:00PM – 9:30PM Richard Padgett, Rutgers University, Piscataway, USA
Smad signaling in C. elegans
9:30PM – 10:00PM Coleen Murphy, Princeton University, Princeton, New Jersey, USA
Sma/Mab signaling mutations uncouple reproductive aging from somatic aging

Wednesday,July, 31, 2013
7:30AM – 9:00AM Breakfast
Session 5 Smad and non-Smad signaling
9:00AM – 12:30PM Chair: Carl-Henrik Heldin, Ludwig Institute for Cancer Research, Uppsala, Sweden
9:00AM - 9:30AM Carl-Henrik Heldin, Ludwig Institute for Cancer Research, Uppsala, Sweden
TGF-β/TRAF6 signaling in cancer
9:30PM –10:00AM Rik Derynck, University of California, San Francisco, USA
Activation of TGF-β signaling
10:00AM – 10:30AM Xiao-Fan Wang, Duke University Medical Center, Durham, USA
Micro RNAs and tumor metastasis
10:30AM – 11.00AM FASEB Sponsored Coffee Break
11.00AM – 11:30PM Peter ten Dijke, Leiden Unicversity Medical Center, Leiden,
The Netherlands
Novel regulators of TGF-β/Smad signaling in breast cancer
11:30PM – 12:00PM Ying E. Zhang, National Cancer Institute, USA
Controlling chromatin landscape and genome stability through RNF20.
12:00PM – 12:30PM Gareth J Inman, University of Dundee, UK
DAB2 in TGF-β-induced breast cancer intravasation
12:30PM – 1:30PM Lunch
Free Afternoon
4:00PM – 6:00PM Poster Session 2
6:00PM – 7:00PM Dinner
Session 6: Bone and endocrine diseases and young investigators
7:00PM – 10:00PM Chair: Aristidis Moustakas, Ludwig Institute for Cancer Research, Uppsala, Sweden
7:00PM - 7:30PM Chester Brown, Baylor College of Medicine, Houston,
Texas, USA
TGF-β regulation in adiposity and energy expenditure
7:30PM – 8:00PM Eileen M. Shore, University of Pennsylvania, Philadelphia, USA.
An Acvr1 R206H knock-in mouse has fibrodysplasia
ossificans progressiva
8:00PM – 8:30PM Wanjun Chen, National Institutes of Health/NIDCR,
Bethesda, USA
TGF-β in Immune Responses
8:30PM – 9:00PM Break
9:00PM – 9:15PM Damian Medici, Warren Alpert Medical School of Brown University, Providence, RI, USA.
Role of endothelial-mesenchymal transition in heterotopic ossification.
9:15PM – 9:30PM An Zwijsen, KU Leuven, Leuven, Belgium
Stalk cell phenotype depends on integration of Notch and Smad signaling
9:30PM – 9:45PM Short Talk Selected From Submitted Abstracts
9:45PM – 10:00PM Short Talk Selected From Submitted Abstracts

Thursday,August, 1, 2013
7:30AM – 9:00AM Breakfast
Session 7 Systems and structural biology
9:00AM – 12:15PM Chair: Rik Derynck, University of California, San Francisco, USA
9:00AM - 9:30AM Markos Gonzalez Gaitan, University of Geneva, Geneva, Switzerland
Understanding morphogenetic growth control -- lessons from flies
9:30PM –10:00AM Xuedong Liu, University of Colorado at Boulder, USA
Systems biology approach to TGF-β signaling
10:00AM – 10:30AM Timothy Springer, Harvard Medical School, Boston, Massachusetts 02115, USA
Latent TGF-β structure and activation
10:30AM – 11.00AM FASEB Sponsored Coffee Break
11:00AM – 11:30PM Jay Groppe, Baylor College of Dentistry, Texas A & M Health Science Center, Dallas, Texas, USA
Activities of ALK2 receptor kinases
11:30PM – 12:00PM Stewart Newfeld, Arizona State University, Tempe, USA
Dpp morphogen gradient during dorsal-ventral axis formation
12:00PM – 12:15PM Alex Bullock, University of Oxford, Oxford, UK.
Structural basis for inhibition of TGF-b receptors with small compounds
12:15PM – 12:45PM Business Meeting
12:45PM – 1:45PM Lunch
Free Afternoon
1:00PM – 6:00PM Optional Organized Group Activity
6:00PM – 7:00PM Dinner
Session 8:
7:00PM – 9:45PM
Cardiovascular diseases and cancer
Chair: Akiko Hata, University of California, San Francisco, USA
7:00PM - 7:30PM Akiko Hata, University of California, San Francisco, USA
Mechanism of Smad-dependent microRNA maturation
7:30PM – 8:00PM Helen Arthur, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK
TGF-β in cardiovascular diseases
8:00PM – 8:30PM Rosemary Akhurst, University of California at San Francisco, San Francisco, California, USA
` Genetic modifiers of hereditary haemorrhagic telangiectasia
8:30PM – 8:45PM Break
8:45PM – 9:15PM Harold Moses, Vanderbilt-Ingram Cancer Center
Mechanisms of TGF-β enhancement of tumor progression
9:15PM – 9:30PM Xiao-Jing Wang, University of Colorado, Denver, USA
Smads in skin and head and neck cancer
9:30PM – 10.00PM Jonathan Yingling, Eli Lilly and Co, Indianapolis, USA
Clinical trials progress of TGF-β receptor kinase inhibitors

Friday,August, 2, 2013
7:30AM – 8:30AM Breakfast
END OF CONFERENCE

28 Jul - 2 Aug 2013

Steamboat Springs
United States of America
meeting website