Matricellular Proteins in Development, Health, and Disease

Matricellular Proteins in Development, Health, and Disease
+ show speakers and program
Sunday, July 28, 2013
4:00PM – 9:00AM Conference Registration
6:00PM – 7:00 PM FASEB Opening Reception
7:00PM – 8:00 PM Dinner
8:00PM – 9:20 PM Matricellular proteins: local and global actions
Session Chair: Themis Kyriakides, Yale University
Deane Mosher, University of Wisconsin
“Periostin: a major player in TH2 immunity conditioned ECM”
Hiromi Yanagisawa, University of Texas Southwestern
“Fibulins and MMPs in regulation of connective tissue integrity””

Monday,July 29, 2013
7:30AM – 9:00AM Breakfast
Session 1:
9:00AM – 12:30 PM
Matricellular protein regulation and receptors
Session Chair: Olga Stenina Adognravi, Cleveland Clinic
9:00AM – 9:15AM Welcome from FASEB
9:15AM - 9:45AM David Roberts (NCI, NIH)
“Thrombospondin-1, c-Myc, and stem cell reprogramming”
9:45AM –10:15AM Olga Stenina Adognravi (Cleveland Clinic)
“Cell and tissue specific regulation of TSP1 production”
10:15AM – 10:30 AM Short talk selected from submitted abstracts
10:30AM – 11:00 AM Group photo & FASEB Sponsored Coffee Break
11:00AM – 11:30 AM Ruth Chiquet-Ehrismann (Friedrich Miescher Institute for
Biomedical Research, Switzerland)
“Discovery of novel Mkl1 target genes co-regulated with
tenascin-C and their role in breast cancer progression”
11:30AM – 12:00 PM Dominik Haudenschild, UC Davis School of Medicine
“Mechanoresponsive COMP promoter regions”
12:00 PM – 12:15 PM Short talk from selected abstracts
12:15PM – 1:15 PM Lunch
Free Afternoon
4:00PM – 6:00PM Poster Session 1
6:00PM – 7:00PM Dinner
Session 2:
7:00PM – 9:45PM
Matricellular proteins in non-mammalian model systems and
development
Session Chair: Josephine Adams, University of Bristol, UK
7:00PM - 7:30PM Jo Adams, University of Bristol
"Thrombospondins in context"
7:30PM – 8:00PM Talila Volk, Weizmann Institute, Israel
“Drosophila collagen 18-like gene TSP repeats and cardiac lumen
formation”
8:00PM – 8:15PM Short talk
8:15PM – 8:30PM Break
8:30PM – 8:45PM Short talk
8:45PM – 9:15PM David Sherwood, Duke University
“SPARC and c. elgans”
9:15PM – 9:45PM Maurice Ringuette, University of Toronto
“SPARC in Xenopus and Drosophila development: impact on collagen
IV in adipose tissue”

Tuesday,July 30, 2013
7:30AM – 9:00AM Breakfast
Session 3
9:00AM – 12:15PM
Matricellular protein regulation of growth factor activity
Session Chair: Andrew Leask, University of Western Ontario
9:00AM - 9:30AM Andrew Leask, University of Western Ontario
“CCN2: a common downstream mediator of fibrosis”
9:30PM –10:00AM Rolf Brekken, University of Texas Southwestern
“SPARC, TGF-β, and EMT”
10:00AM – 10:15AM Short talk
10:15AM – 10:45AM FASEB Sponsored Coffee Break
10:45AM – 11:15AM Jack Lawler, Harvard
“TSP1 and VEGF signaling”
11:15AM – 11:45AM Maria Trojanowska, Boston University
“CCN2 and TGF-β signaling through Smad1/ERK”
12:00PM – 12:15PM Short talk
12:15PM – 1:15PM
1:15PM – 2:15PM
Lunch
Meet the Expert
Free Afternoon
4:00PM – 6:00PM Poster Session 2
6:00PM – 7:00PM Dinner
Session 4:
7:00PM – 9:45PM
Matricellular proteins in inflammation and immunity
Session Chair: Kim Midwood, Oxford University, UK
7:00PM - 7:30PM Kim Midwood, Oxford University
"Matricellular proteins in immunity: a pro-inflammatory niche"
7:30PM – 8:00PM Lester Lau, University of Illinois Chicago
"CCN1 and inflammation"
8:00PM – 8:15PM Short talk
8:15PM – 8:30PM Break
8:30PM – 8:45PM Short talk
8:45PM – 9:15PM Katherine L. Knight, Loyola University
“Periostin and B cell development”
9:15PM – 9:45PM Junko Morimoto, Hokkaido University, Japan
“Interactions between matricellular proteins and integrins modulate
immune responses”

Wednesday,July 31, 2013
7:30AM – 9:00AM Breakfast
Session 5
9:00AM – 12:15PM
Matricellular proteins in diabetes and obesity
Session Chair: Joanne Murphy-Ullrich, University of Alabama at
Birmingham
9:00AM - 9:30AM Shuxia Wang, University of Kentucky
“TSP1: role in obesity-induced inflammation and insulin sensitivity”
9:30PM –10:00AM Dwight Towler, Sanford Burnham Medical Research Institute at Lake
Nona
“Osteopontin signaling in diabetic vascular disease”
10:00AM – 10:15AM Short talk
10:15AM – 10:45AM FASEB Sponsored Coffee Break
10:45AM – 11:15AM Stephen Twigg, University of Sydney, Australia
“Growth factors in diabetic complications: focus on the CCN family”
11:15AM – 11:45AM Bruce L. Riser, Rosalind Franklin University of Medicine and
Science/Baxter Healthcare
“CCN interactions: basis for novel treatments in complications of
diabetes and obesity”
12:00PM – 12:15PM Short talk
12:15PM – 1:15PM Lunch
Free Afternoon
4:00PM – 6:00PM Poster Session 3
6:00PM – 7:00PM Dinner
Session 6:
7:00PM – 9:45PM
Matricellular proteins in cardiovascular disease
Session Chair: Jeffrey Isenberg, University of Pittsburgh
7:00PM - 7:30PM Themis Kyriakides, Yale University
“Thrombospondin-2 and the eNOS/Akt axis in vascular remodeling”
7:30PM – 8:00PM Stephane Heymans, Maastricht University Medical Center,
Netherlands
“SPARC and TSP2 in cardiac inflammation”
8:00PM – 8:15PM Short talk
8:15PM – 8:30PM Break
8:30PM – 8:45PM Short talk
8:45PM – 9:15PM Amy Bradshaw, Medical University of South Carolina
“SPARC in vascular/cardiac collagen assembly “
9:15PM – 9:45PM Jeffrey Isenberg, University of Pittsburgh
“Activated CD47 promotes pulmonary arterial hypertension”

Thursday,August 1, 2013
7:30AM – 9:00AM Breakfast
Session 7
9:00AM – 12:15PM
Matricellular proteins in carcinogenesis and angiogenesis
Session Chair: Gertraud Orend, University of Strasbourg, France
9:00AM - 9:30AM Gertraud Orend, University of Strasbourg
“Tenascin-C matrix niches and their multiple roles in cancer”
9:30PM –10:00AM Sajani Lakka, University of Illinois College of Medicine at Chicago
“SPARC in medulloblastoma tumorigenesis”
10:00AM – 10:15AM Short talk
10:15AM – 10:45AM FASEB Sponsored Coffee Break
10:45AM – 11:15AM Paul C Kuo, Loyola University
“Osteopontin and the tumor microenvironment”
11:15AM – 11:45AM Giulia Taraboletti, Mario Negri Institute for Pharmacological
Research, Italy
“TSP1 type 3 repeats and tumorigenesis and angiogenesis”
11:45AM – 12:15PM Business Meeting
12:15PM – 1:15PM Lunch
Free Afternoon or Optional Organized Group Activity
6:00PM-7:00PM Dinner
Session 8:
7:00PM – 9:45PM
Matricellular proteins in neuronal systems
Session Chair: Cagla Eroglu, Duke University
7:00PM - 7:30PM Cagla Eroglu, Duke University
“Astrocyte-secreted matricellular proteins TSP, hevin, and SPARC
orchestrate synaptic development in the central nervous system”
7:30PM – 8:00PM Keith Murai, McGill University
"Role of SPARC in synaptic regulation and central nervous system
disease"
8:00PM – 8:15PM Short talk
8:15PM – 8:30PM Break
8:30PM – 8:45PM Short talk
8:45PM – 9:15PM Lara Kular, Karolinska Hospital, Sweden
“Role of NOV/CCN3 in chronic pain processes and
neuroinflammation”
9:15PM – 9:45PM ZD (David) Luo, UC-Irvine
“How thrombospondin-4 mediates spinal neuron hyperexcitability and
neuropathic pain states”

Friday,August 2, 2013
7:30AM – 8:30AM Breakfast
Session 9
8:30AM – 11:30AM
Matricellular proteins in musculoskeletal disease
Session Chair: Kurt Hankenson, University of Pennsylvania
8:30AM - 9:00AM Enrique Brandan, Catholic University of Chile, Chile
“Inhibition of fibrosis increases skeletal muscle function in Duchenne
Muscular Dystrophy”
9:00AM – 9:30AM Masaharu Takigawa, Okayama University Graduate School of
Medicine, Dentistry, and Pharmaceutical Sciences, Japan
“Roles of CCN2 and CCN3 in skeletal growth”
9:30AM – 9:45AM Short talk
9:45AM – 10:00AM Break
10:00AM – 10:15AM Short talk
10:15AM – 10:45AM Frank Zaucke, University of Cologne, Germany
“The role of the matricellular proteins COMP and matrilin-3 in skeletal
development and disease”
10:45AM – 11:15AM Kurt Hankenson, University of Pennsylvania
“R-spondins enhance BMP-induced bone formation by increasing
canonical Wnt signaling”
11:15AM – 11:30AM Closing Comments
11:30AM Departures
Boxed Lunches Available
END OF CONFERENCE

28 Jul - 2 Aug 2013

Saxtons River
United States of America
meeting website