Genetic Recombination & Genome Rearrangements

Genetic Recombination & Genome Rearrangements
+ show speakers and program
(All titles are tentative)
Sunday, July 21, 2013
4:00PM – 9:00PM Conference Registration
6:00PM – 7:00 PM FASEB Opening Reception
7:00PM – 8:30 PM Dinner
8:45PM – 10:00PM Keynote Speaker:
Stephen Kowalczykowski, University of California, Davis
“Visualization and mechanism of recombination”

Monday, July 22, 2013
7:30AM – 9:00AM Breakfast
Session 1: 9:00AM – 12:25PM Biochemistry of Recombination and Mechanisms
Stephen West, Cancer Research UK
9:00 Welcome from FASEB
9:05 Stephen West, Cancer Research UK
“Mechanism and regulation of Holliday junction resolution”
9:35 Michael Cox, University of Wisconsin
“A RecA-dependent nuclease: the Ref protein”
10:00 John Rouse, MRC, University of Dundee
“Regulation of DNA repair nucleases in mammals”
10:25-10:55 Group photo & FASEB Sponsored Coffee Break
11:00 Dale Wigley, Institute of Cancer Research, London
“Crystal structure of a complex AddAB with Chi”
11:25 Karl Peter Hopfner, LMU Munich
“Mechanism of sensing and signaling of DNA double-strand
breaks by the MRN complex”
11:40 Eric Greene, Columbia University
"Visualizing protein-DNA interactions at the single-molecule level
using DNA curtains"
11:55 Late breaking abstract
“tba”
12:10 Late breaking abstract
“tba”
12:30PM-1:30PM Lunch
1:30PM-3:00PM Free Time
Session 2: 3:00PM – 6:10PM Replication, repair and recombination in Eukaryotes
Simon Boulton, Cancer Research UK
3:00 Simon Boulton, Cancer Research UK
“Regulation of DSB pathway choice”
3:30 Sue Jinks Robertson, Duke University
“A requirement for translesion synthesis DNA polymerases for
efficient gap repair in yeast”
3:55 Ginger Zakian, Princeton University
“Pif1 family helicases: diverse roles in genome integrity”
4:20-4:50 Coffee Break
4:50 Andres Aguilera, Universidad de Sevilla
“Understanding transcription-associated recombination through
specific RNAPII mutants”
5:15 Maria Jasin, Memorial Sloan Kettering Cancer Center
"Double-strand break repair in mammalian cells"
5:40 Sarah Lambert, Institut Curie, Orsay
“Chromatin assembly in the context of homologous recombination”
5:55 Late breaking abstract
“tba” short
6:15PM – 7:15PM Dinner
Poster Session 1
7:30PM-8:30PM Odd Posters
8:30PM-9:30PM Even Posters

Tuesday, July 23, 2013
7:30AM – 9:00AM Breakfast
Session 3: 9:00AM – 12:15PM Eukaryotic Recombination Genetics
Lorraine Symington, Columbia University
9:00 Lorraine Symington, Columbia University
"DNA end resection and repair pathway choice”
9:30 Tom Petes, Duke University
“Genetic regulation of spontaneous and damage-induced mitotic
recombination events in yeast”
9:55 Jeff Sekelsky, University of North Carolina
“Anti-recombinogenic roles of helicases during DSB repair in
human cells”
10:20-10:50 FASEB Sponsored Coffee Break
10:50 Rodney Rothstein, Columbia University
“Exploring increased chromosome mobility during DSB repair”
11:15 Valerie Borde, Institut Curie, Paris
“Influence of chromatin on meiotic recombination hotspots”
11:30 Late breaking abstract
“tba"
11:45 Late breaking abstract
“tba”
12:00 Late breaking abstract
“tba”
12:20PM-1:20PM Lunch
1:20PM-3:00PM Free Time
1:20PM-2:15PM Meet the Expert Session
(concurrent with free afternoon)
Session 4: 3:00PM – 6:10PM Genome Rearrangements and Evolution
Richard Kolodner, Ludwig Institute for Cancer Research,
San Diego
3:00 Richard Kolodner, Ludwig Institute for Cancer Research,
San Diego
“Elucidation of a large-scale genetic network that suppresses
genome instability in S. cerevisiae”
3:30 Titia de Lange, Rockefeller University
“How telomeres solve the end-protection problem”
3:55 Peter Campbell, Sanger Center
“Interrogating the architecture of cancer genomes”
4:20-4:50 Coffee Break
4:50 John Roth, University of California, Davis
"Formation of gene duplications - reckless recombination"
5:15 Anna Malkova, Indiana University
“Molecular mechanism and destabilizing consequences of breakinduced
replication”
5:40 Kirill Lobachev, Georgia Tech, Atlanta
“Mechanisms of double-strand break formation at the location of
structure-forming repeats”
5:55 Late breaking abstract
“tba”
6:15PM-7:15PM Dinner
Poster Session 2
7:40PM-8:40PM Odd Posters
8:40PM-9:40PM Even Posters

Wednesday, July 24, 2013
7:30AM – 9:00AM Breakfast
Session 5: 9:00AM – 12:10PM Meiosis
Denise Zickler, Université Paris Sud
9:00 Denise Zickler, Université Paris Sud
"ZMM proteins differentially shape pairing and synapsis during
Sordaria meiosis"
9:30 Scott Keeney, Memorial Sloan-Kettering Cancer Center
“Mechanism and regulation of meiotic recombination initiation”
9:55 Neil Hunter, University of California, Davis
“Regulating the outcome of recombination during meiosis”
10:20-10:50 FASEB Sponsored Coffee Break
10:50 Bernard DeMassy, IGH Montpellier
“Initiation of meiotic recombination in mice”
11:15 Nancy Kleckner, Harvard University
“Making decisions during meiotic recombination”
11:40 Abby Dernburg, University of California, Berkeley
"Crossover regulation in C. elegans meiosis"
12:05 Galina Petukhova, Uniformed Services University, Bethesda
“Initiation of homologous recombination in mammals”
12:30PM-1:30PM Lunch
1:30PM-4:30PM Free Afternoon/Organized activities
Poster session 3
4:30PM-5:15PM Odd Posters
5:15PM-6:00PM Even Posters
6:00PM-7:00PM Dinner
Session 6: 7:30PM – 10:10PM Replication, repair and recombination in prokaryotes
Sue Lovett, Brandeis University
7:30 Sue Lovett, Brandeis University
“RadA, E. coli's RecA paralog”
8:00 David Leach, University of Edinburgh
“DNA double strand break repair at a single break in the E. coli
chromosome”
8:25 David Sherratt, University of Oxford
“In vivo biochemistry of homologous recombination”
8:50-9:20 Coffee Break
9:20 Ken Marians, Memorial Sloan-Kettering Cancer Center
“Mechanisms of replication restart”
9:45 Bénédicte Michel, CNRS, Gif Sur Ivette
“In vivo analysis of homologous recombination and replication fork
arrest by single molecule microscopy"

Thursday, July 25,2013
7:30AM – 9:00AM Breakfast
Session 7: 9:00AM – 11:55PM Maintenance of Genome integrity
Tanya Paull, University of Texas, Austin
9:00 Tanya Paull, University of Texas, Austin
"Regulation of DNA double-strand break repair and signaling by
the MRN complex"
9:30 John Petrini, Memorial Sloan-Kettering Cancer Center
“Genetic analysis of chromosome break metabolism in
eukaryotes"
9:55 Alain Nicolas, Institut Curie, Paris
“G-quadruplexes: structure and function in genome instability”
10:20-10:50 FASEB Sponsored Coffee Break
10:50 Geneviève Almouzni, Institut Curie, Paris
"Chromatin assembly from nucleosome to heterochromatin: the
issue of DNA damage"
11:15 Marco Foiani, IFOM Milano
"Mechanisms coordinating the clash between replication and
transcription"
11:40 Huilin Zhou, Ludwig Institute for Cancer Research,
San Diego
"Post-translational protein modifications in suppressing genome
rearrangements"
12:00 Business Meeting
12:30PM-1:30PM Lunch
1:30PM-3:00PM Free Afternoon
Session 8: 3:00PM – 6:10PM Recombination Mechanisms
Douglas Bishop, University of Chicago
3:00 Douglas Bishop, University of Chicago
“Biochemical reconstitution of meiotic recombination”
3:30 Jim Haber, Brandeis University
"Genome stability and instability during DSB repair"
3:55 Roland Kanaar, University of Rotterdam
“Mechanisms of homologous recombination in mammalian cells”
4:20 -4:50 Coffee Break
4:50 Patrick Sung, Yale University
"Roles of the conserved helicase Mph1 in DNA Repair"
5:15 Akira Shinohara, Osaka University
“Control of meiotic recombination by chromosome dynamics”
5:40 Late breaking abstract
”tba ”
5:55 Late breaking abstract
“tba”
6:15PM-7:15PM Dinner
8:00PM Entertainment

Friday, July 26, 2013
7:30AM – 8:30AM Breakfast
Departure
END OF CONFERENCE

21 Jul - 26 Jul 2013

Steamboat Springs
United States of America
meeting website