Biology of Calpains in Health and Disease

Biology of Calpains in Health and Disease
+ show speakers and program
Sunday,July 21, 2013
4:00PM – 9:00AM Conference Registration
6:00PM – 7:00 PM FASEB Opening Reception
7:00PM – 8:30 PM Dinner
8:45PM – 10:00PM Keynote Talk:
Peter Davies, Queen’s University
“Structure of calpain and calpastatin”

Monday,July 22, 2013
7:30AM – 9:00AM Breakfast
Session 1:
9:00AM – 12:15PM
Bioinformatics of Calpain Substrates Session Chair Name,
Session Chair Hiroyuki Sorimachi, Tokyo Metropolitan Institute of
Medical Science
9:00AM – 9:15AM Welcome from FASEB
9:15AM - 9:45AM Hiroyuki Sorimachi, Tokyo Metropolitan Institute of Medical Science
“Calpain cleavage prediction using multiple kernel learning”
9:45AM –10:15AM Daniel MacQueen*, University of St Andrews, Fife
“Molecular Evolution of Calpains”
10:15AM – 10:30 AM “New and Notable” Talk Selected From Submitted Abstracts
10:30AM – 11:00AM Group photo & FASEB Sponsored Coffee Break
11:00AM – 11:30AM Yi-Shiuan Huang. Institute of Biomedical Sciences, Academia
Sinica
“Calpain 2 activated through the NMDA receptor signaling cleaves
CPEB3”
11:30AM – 12:00PM Tetsumori Yamashima, University Graduate School of Medical
Science, Kanazawa,
“Why are hippocampal CA1 neurons so vulnerable to transient
ischemia?”
12:00PM – 12:15PM “New and Notable” Talk Selected From Submitted Abstracts
12:15PM – 1:15PM Lunch
Free Afternoon
4:00PM – 6:00PM Poster Session 1
6:00PM – 7:00PM Dinner
Session 2:
7:00PM – 9:45PM
Calpains and Cancer
Session Chair Peter Greer, Queen’s University
7:00PM - 7:30PM Stewart Martin, University of Nottingham
“The calpain system and cancer”
7:30PM – 8:00PM Maralice Conacci-Sorrell*, Fred Hutchinson Cancer Research
Center
“Calpain-induced Myc-nick in colon cancer”
8:00PM – 8:15PM “New and Notable” Talk Selected From Submitted Abstracts
8:15PM – 8:30PM Break
8:30PM – 8:45PM “New and Notable” Talk Selected From Submitted Abstracts
8:45PM – 9:15PM Alan Wells, University of Pittsburgh
“Calpains as potential anti-cancer targets”
9:15PM – 9:45PM Peter Greer, Queen’s University
“Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway
in mammary carcinoma”

Tuesday,July 23, 2013
7:30AM – 9:00AM Breakfast
Session 3
9:00AM – 12:15PM
Measuring Calpain Activation
Session Chair Kevin Wang, University of Florida
9:00AM - 9:30AM Kevin Wang, University of Florida
“Calpain substrates as biomarkers for injury and disease”
9:30PM –10:00AM John Anagli, Henry Ford Health System
“Absolute quantitation of neuronal-glial injury biomarkers”
10:00AM – 10:15AM “New and Notable” Talk Selected From Submitted Abstracts
10:15AM – 10:45AM FASEB Sponsored Coffee Break
10:45AM – 11:15PM Kiyotoshi Kaneko*, Tokyo Medical University
“In vivo imaging of prion cleavage by calpain”
11:15PM – 12:00PM Hiroyuki Sorimachi, Tokyo Metropolitan Institute of Medical Science
“Novel aspects of activation mechanisms of CAPN3 and CAPN8/9
and their in vitro assay”
12:00PM – 12:15PM “New and Notable” Talk Selected From Submitted Abstracts
12:15PM – 1:15PM
1:15PM – 2:15PM
Lunch
Meet the Expert
Free Afternoon
6:00PM – 7:00PM Dinner
Session 4:
7:00PM – 9:45PM
Calpain in Cell Death Pathways
Session Chair Jim Geddes, University of Kentucky
7:00PM - 7:30PM Junying Yuan, Harvard University
“Control of basal autophagy by calpain-1 mediated cleavage of
ATG5”
7:30PM – 8:00PM Jinsoo Seo, Picower Institute For Learning and Memory, MIT
“Calpain, CDK5, and neurodegeneration”
8:00PM – 8:15PM “New and Notable” Talk Selected From Submitted Abstracts
8:15PM – 8:30PM Break
8:30PM – 8:45PM “New and Notable” Talk Selected From Submitted Abstracts
8:45PM – 9:15PM Fumi Urano, U. Mass. Medical School
“Calpains, autophagy, ER stress and diabetes”
9:15PM – 9:45PM James Geddes, University of Kentucky
“Calpain 5: An atypical calpain abundant in the CNS”

Wednesday,July 24, 2013
7:30AM – 9:00AM Breakfast
Session 5
9:00AM – 12:15PM
Calpains in Diabetes and Other Disorders
Session Chair Athar Chishti, Tufts University
9:00AM - 9:30AM Ingrid Fleming, Goethe-Universität,
“The role of calpain in diabetes-associated platelet
hyperactivation”
9:30PM –10:00AM Tianqing Peng, University of Western Ontario
“Calpain in diabetes-associated myocardial hypertrophy and
fibrosis”
10:00AM – 10:15AM “New and Notable” Talk Selected From Submitted Abstracts
10:15AM – 10:45AM FASEB Sponsored Coffee Break
10:45AM – 11:15PM Athar Chishti, Tufts University
“Calpain 1 and sickle cell disease”
11:15PM – 12:00PM Adam Goldfarb, University of Virginia
“Calpain-2 promotes megakaropoesis through activation of Cdk9”
12:00PM – 12:15PM “New and Notable” Talk Selected From Submitted Abstracts
12:15PM – 1:15PM Lunch
Free Afternoon
4:00PM – 6:00PM Poster Session 2
6:00PM – 7:00PM Dinner
Session 6:
7:00PM – 9:45PM
Calpains in Neurodegeneration
Session Chair David Park, University of Ottawa
7:00PM - 7:30PM Takaomi Saido, RIKEN Brain Science Institute
“Mouse models of Alzheimer’s disease”
7:30PM – 8:00PM Shin Kwak, University of Tokyo
“Calpain cleavage of TDP-43 in amyotrophic lateral sclerosis”
8:00PM – 8:15PM Break
8:15PM – 8:45PM Yoshiyuki Tamada, Senju Pharmaceuticals
“Calpain activation/inhibition and retinal disease”
8:45PM – 9:15PM Michel Baudry , Western University of Health Sciences
“Novel roles of calpains in synaptic plasticity and
neurodegeneration”
9:15PM – 9:45PM Kathy Saatman, University of Kentucky
“Calpain as a therapeutic target in traumatic brain injury”

Thursday,July 25, 2013
7:30AM – 9:00AM Breakfast
Session 7
9:00AM – 12:15PM
Calpains in Cardiovascular Diseases
Session Chair Kinya Otsu, King’s College
9:00AM - 9:30AM Rosario Scalia, Temple University
“Novel role for calpain in endothelial dysfunction induced by
activation of angiontensin II type I receptor signaling.”
9:30PM –10:00AM Andreas Goette, St. Vincenz Hospital, Paderborn, Germany,
“Physiologic and pathophysiologic roles of calpain: Implications for
the occurrence of atrial fibrillation.”
10:00AM – 10:15AM “New and Notable” Talk Selected From Submitted Abstracts
10:15AM – 10:45AM FASEB Sponsored Coffee Break
10:45AM – 11:15PM Yunchao Su, Medical College of Georgia, Augusta, GA
“Calpain in pulmonary vascular remodeling”
11:15PM – 12:00PM Kinya Otsu, King’s College
“Conventional calpains protect the heart”
12:00PM – 12:15PM “New and Notable” Talk Selected From Submitted Abstracts
12:15PM – 12:45PM Business Meeting
12:45PM – 1:45PM Lunch
Free Afternoon
1:00PM – 6:00PM Optional Organized Group Activity
6:00PM – 7:00PM Dinner
Session 8:
7:00PM – 9:45PM
Calpains in Muscle
Session Chair Elisabeth Huff-Lonergan, Iowa State University
7:00PM - 7:30PM Elisabeth Huff-Lonergan, Iowa State University
“Biochemistry of muscle: Relevance of postmortem changes to
aging”
7:30PM – 8:00PM Melissa Spencer, University of California, Los Angeles
“Blunted signaling pathways in the pathogenesis of calpainopathy”
8:00PM – 8:15PM “New and Notable” Talk Selected From Submitted Abstracts
8:15PM – 8:30PM Break
8:30PM – 8:45PM “New and Notable” Talk Selected From Submitted Abstracts
8:45PM – 9:15PM Carol Lorenzen, University of Missouri
“Calpastatin biosensors”
9:15PM – 9:45PM To Be Determined

Friday,July 26, 2013
7:30AM – 8:30AM Breakfast
Session 9
8:30AM – 11:30PM
Murachi and Goll Awards
Jim Geddes and Peter Greer
8:30AM – 8:40 AM Murachi Award Winner--Predoctoral
8:45AM – 9:00AM Murachi Award Winner--Postdoctoral
9:30AM – 9:45AM Goll Award Winner—Junior Faculty
9:45AM – 10:00AM Break
10:00AM – 11:15AM Discussion and Planning for Next Conference
11:15AM – 11:30AM Closing Comments
11:30AM Departures
Boxed Lunches Available
END OF CONFERENCE

21 Jul - 26 Jul 2013

Saxtons River
United States of America
meeting website