Protein Lipidation, Signaling, and Membrane Domains

Protein Lipidation, Signaling, and Membrane Domains
+ show speakers and program
Sunday, July 14, 2013
4:00 PM – 9:00 PM Conference Registration
6:00 PM – 7:00 PM FASEB Opening Reception
7:00 PM – 8:30 PM Dinner
8:45 PM – 9:45 PM Keynote Speaker,
Philip Beachy*, Stanford University
“Dual modification of secreted signaling proteins by
cholesterylation and palmitoylation”

Monday, July 15, 2013
7:30 AM – 9:00 AM Breakfast
Session 1: 9:00 AM – 12:15 PM Membrane-Bound O-Acyl Transferases (MBOATs),
GPI-Linked Proteins, and Secreted Lipidated
Signaling Proteins
Chair: Anthony Magee*, Imperial College, UK
9:00 AM – 9:15 AM Welcome from FASEB and Organizers
9:15 AM – 9:45 AM Rami Hannoush*, Genentech, San Francisco, CA
“Membrane targeting of palmitoylated Wnt and
Hedgehog revealed by chemical probes”
9:45 AM – 10:15 AM Anthony Magee*, Imperial College, UK
“Cholesterylation and cancer”
10:15 AM – 10:45 AM Tongjin Zhao*, University of Texas Southwestern
“Octanoylation of ghrelin and appetite control”
10:45 AM – 11:00 AM Coffee Break
11:00 AM – 11:30 AM Taroh Kinoshita*, Osaka University, Japan
“Remodeling and function of GPI anchors in protein
sorting, trafficking, and dynamics”
11:30 AM – 12:00 PM Satyajit Mayor*, National Center for Biological
Sciences, Bangalore, India
“Cytoskeletal regulation of GPI-anchored proteins in
membranes”
12:00 PM – 12:15 PM Group Photo
12:15 PM – 2:00 PM Lunch
Session 2: 2:00 PM – 4:45 PM Lipid Modification in Health and Disease
Chair: Stephen Young*, UCLA, Los Angeles, CA
2:00 PM - 2:30 PM Eric Verdin, Gladstone Institute, UCSF (tentative)
(TBA)
2:30 PM – 3:00 PM Christine Hrycyna*, Purdue University, Lafayette, IN
“Icmt as therapeutic targets”
3:00 PM – 3:15 PM Break
3:15 PM – 3:45 PM Yoel Kloog*, Tel Aviv University
“Targeting Ras in pancreatic cancer”
3:45 PM – 4:15 PM Channing Der*, University of North Carolina
“Unique roles of RalA and RalB in different types of
cancer”
4:15 PM – 4:45 PM Robert Chapkin*, Texas A&M University
Topic TBD
5:00 PM – 6:00 PM Poster Session 1
Short oral presentations of posters by students
and postdoctoral fellows
6:30 PM – 8:00 PM Dinner
8:00 PM – 9:00 PM Evening Plenary Lecture
Stephen Young*, UCLA, Los Angeles, CA
“Lipid modification of nuclear lamins in progeria”
9:00 PM – Midnight Bar Open (Full Cash Bar)

Tuesday, July 16, 2013
7:30 AM – 9:00 AM Breakfast
Session 3: 9:00 AM – 12:00 PM Biology of Protein Lipidation in Neurons
Chair: Sandra Hofmann*, University of Texas
Southwestern Medical Center, Dallas, TX
9:00 AM – 9:30 AM Gopal Thinakaran*, University of Chicago, IL
“Palmitoylation in Alzheimers Disease”
9:30 AM – 10:00 AM William Green*, University of Chicago, Illinois
Topic TBD
10:00 AM – 10:30 AM Masaki Fukata*, National Institute for Physiological
Sciences, Okazaki, Japan
“Protein palmitoylation in neuronal development and
synaptic plasticity”
10:30 AM – 10:45 AM Coffee Break
10:45 AM – 11:15 AM Mike Shipston*, University of Edinburgh, Scotland
“Ion channel regulation by protein palmitoylation”
11:15 AM – 11:45 AM Sandra Hofmann*, University of Texas Southwestern
Medical Center, Dallas, TX
“Palmitoyl-protein thioesterase defects and neuronal
cell death”
11:45 AM – 12:00 PM Short Talk Selected from Submitted Abstracts
12:00 PM – 1:00 PM Lunch
1:00 PM – 4:00 PM Free Afternoon
4:00 PM – 6:00 PM Poster Session 2
6:00 PM – 7:30 PM Dinner
Session 4: 7:30 PM – 10:00 PM Membrane Trafficking of Lipidated Proteins
Chair: Philippe Bastiaens*, Max Planck Institute
Molecular Physiology, Dortmund, Germany
7:30 PM – 8:00 PM Alistair Hume*, Queen’s Medical Center,
Nottingham, UK
“Regulation of organelle movement by Rab GTPases”
8:00 PM – 8:20 PM Susan Michaelis*, Johns Hopkins University,
Baltimore, MD
“ZMPSTE24 mutations that alter prelamin A
processing in progeroid diseases”
8:20 PM – 8:45 PM Liz Carpenter, University of Oxford, Oxford, UK
“Crystal structure of the CAAX protease ZMPSTE24”
8:45 PM – 9:00 PM Coffee Break
9:00 PM – 10:00 PM Evening Plenary Lecture
Philippe Bastiaens*, Max Planck Institute Molecular
Physiology, Dortmund, Germany
“Intracellular signals propagated by acylationdependent
localization of Ras”
10:00 PM – Midnight Bar Open (Full Cash Bar)

Wednesday, July 17, 2013
7:30 AM – 9:00 AM Breakfast
Session 5: 9:00 AM – 12:00 PM Lipidation in Infectious Diseases
Chair: Luc Berthiaume*, University of Alberta,
Edmonton, AB Canada
9:00 AM – 9:30 AM David M. Engman*, Northwestern University,
Chicago, IL
“Global analysis of protein palmitoylation in African
trypanosomes”
9:30 AM – 10:00 AM TBD
10:00 AM – 10:15 AM Short Talk Selected from Submitted Abstracts
10:15 AM – 10:45 AM FASEB Sponsored Coffee Break
10:45 AM – 11:15 AM David Gray*, University of Dundee, Scotland
“N-myristoyltransferases, Trypanosomes, and cancer”
11:15 AM – 11:45 AM Michael Veit*, Free University Berlin, Germany
“Palmitoylation and membrane localization of viral
proteins”
11:45 AM – 12:00 PM Short Talk Selected from Submitted Abstracts
12:00 PM – 1:30 PM Lunch
1:30 PM – 2:30 PM “Meet the Expert” Session
2:30 PM – 4:00 PM Lipidation Olympics
4:00 PM – 6:00 PM Poster Session 3
6:00 PM – 7:00 PM Dinner
Session 6: 7:00 PM – 9:45 PM Signaling by Lipidated Proteins
Chair: Adrienne Cox, University of North Carolina,
Chapel Hill, NC
7:00 PM – 7:30 PM Martin Bergo*, University of Gottenburg, Sweden
“Hyperactivation of small GTPases by inhibition of
GGTase”
7:30 PM – 8:00 PM Adrienne Cox*, University of North Carolina, Chapel
Hill, NC
“Regulation of signaling by prenylated small
GTPases”
8:00 PM – 8:30 PM Patrick Casey*, Duke University-NUS
“Icmt-mediated methylation in cell migration”
8:30 PM – 8:45 PM Coffee Break
8:45 PM – 9:45 PM Evening Plenary Lecture
Mark Philips*, New York University, NY
“Compartmentalized Ras signaling”
9:45 PM – Midnight Bar Open (Full Cash Bar)

Thursday, July 18, 2013
7:30 AM – 8:30 AM Breakfast
Session 7: 8:30 AM – 12:15 PM Chemical Biology and Proteomics
Chair: Howard Hang*, Rockefeller University, New
York, NY
8:30 AM – 9:00 AM Howard Hang*, Rockefeller University, New York, NY
“Exploring protein lipidation with chemical biology”
9:00 AM – 9:30 AM Nicholas Davis*, Wayne State University, Detroit, MI
“Palmitoylated proteins in vivo: purification and
identification”
9:30 AM – 10:00 AM Mark Distefano*, University of Minnesota,
Minneapolis, MN
“Peptide libraries for studying protein prenylation”
10:00 AM – 10:30 AM FASEB Sponsored Coffee Break
10:30 AM – 11:00 AM Carol Fierke*, University of Michigan, Ann Arbor, MI
“Identification of novel prenylated proteins within the
human proteome”
11:00 AM – 11:30 AM Edward Tate*, Imperial College, London
“Chemical proteomics as a tool for targeting lipid
transferases in disease”
11:30 AM – 11:45 AM Carmela Giglione*, Institut des Sciences du Vegetal,
France
“Fatty acylation of N-termini fine-tune specific
portioning of soluble proteins at the periphery of plant
membranes”
11:45 AM - 12:00 PM Thierry Meinnel*, Institut des Sciences du Vegetal,
France
“Protein N-myristoylation at the proteome scale”
12:00 PM – 12:30 PM Business Meeting
12:30 PM – 1:30 PM Lunch
1:30 PM – 6:00 PM Organized Group Activity: Canoe Trip
6:00 PM – 7:30 PM Banquet Dinner
Session 8: 7:30 PM – 10:00 PM Clinical Significance of Palmitoylation
Chair: Maurine Linder*, Cornell University, Ithaca,NY
7:30 PM – 8:00 PM Robert Deschenes*, University of South Florida,
Tampa, FL
“Ras palmitoyltransferases in cancer”
8:00 PM – 8:30 PM Maurine Linder*, Cornell University, Ithaca, NY
“Regulation of protein localization and function by
palmitoylation”
8:30 PM – 8:45 PM Short Talk Selected from Submitted Abstracts
8:45 PM – 9:00 PM Coffee Break
9:00 PM – 10:00 PM Evening Plenary Lecture
Luc Berthiaume*, University of Alberta, Edmonton,
AB Canada
“Targeting protein fatty acyltransferases in cancers”
10:00 PM – Midnight Bar Open (Full Cash Bar)

Friday, July 19, 2013
7:30 AM – 8:30 AM Breakfast
Session 9: 8:30 AM – 12:00 PM Membrane Microdomains: From Organization to
Signaling
Chair: Anne Kenworthy*, Vanderbilt University,
Nashville, TN
8:30 AM – 9:00 AM Martin Schwartz* Yale University, New Haven, CT
“Lipid raft components and signaling”
9:00 AM – 9:30 AM John Hancock, University of Texas Health Science
Center, Houston, TX
“Plasma membrane nanostructure and signal
transducation”
9:30 AM – 10:00 AM Rick Cerione*, Cornell University, Ithaca, NY
“Biogenesis of membrane microvesicles and
transformation”
10:00 AM – 10:15 AM Coffee Break
10:15 AM – 10:45 AM Vytas Bankaitis*, Texas A&M Health Science
Center, College Station, TX
“Novel mechanisms of crosstalk between endosomal
lipid signaling and nuclear pathways for growth
control and stress management”
10:45 AM – 11:15 AM Fred Maxfield*, Weill Cornell Medical College, New
York, NY
“Endocytic membrane traffic of receptors, ligands, and
membrane lipid components”
11:15 AM – 11:45 AM Anne Kenworthy*, Vanderbilty University, Nashville,
TN
“Tracking microdomain dynamics in cell membranes”
11:45 AM – 12:00 PM Closing, Luc Berthiaume and Carol Williams
12:00 PM Departures, Boxed Lunches Available
END OF CONFERENCE
*Confirmed speakers

14 Jul - 19 Jul 2013

Saxtons River
United States of America
meeting website