From Unfolded Proteins in the ER to Disease

From Unfolded Proteins in the ER to Disease
+ show speakers and program
Sunday June 16, 2013
4:00PM – 9:00PM Conference Registration
6:00PM – 7:00 PM FASEB Opening Reception
7:00PM – 8:30 PM Dinner
8:45PM – 10:00PM Keynote Speaker Matthew Freeman, Laboratory of Molecular
Biology, MRC Cambridge UK
“The interface between ER quality control and signaling: iRhoms
and their relatives"

Monday June 17, 2013
7:30AM – 9:00AM Breakfast
Session 1:
9:00AM – 12:15PM
Protein Entry and Folding at the ER
Session Chair Jonathan Weissman, University of California, San
Francisco
9:00AM – 9:15AM Welcome from FASEB
9:15AM - 9:45AM Speaker 1, Ramanujan Hegde, LMB, MRC, Cambridge, UK
"Pre-ER Quality Control"
9:45AM –10:15AM Speaker 2, Dan Hebert, University of Massachusetts, Amherst
“Pathways of Co-translational Protein Folding in the ER”
10:15AM – 10:30 AM Short Talk Selected From Submitted Abstracts
10:30AM – 11:00AM Group photo & FASEB Sponsored Coffee Break
11:00AM – 11:30AM Speaker 3, Mark Hochstrasser, Yale University
"Multiple routes of protein degradation at the ER membrane"
11:30AM – 12:00PM Speaker 4, Chris Nicchitta, Duke University Medical Center
"ER associated ribosomes and messages"
12:00PM – 12:15PM Short Talk Selected From Submitted Abstracts
12:15PM – 1:15PM Lunch
Free Afternoon
4:00PM – 6:00PM Poster Session 1
6:00PM – 7:00PM Dinner
Session 2:
7:00PM – 9:45PM
Mechanisms of Protein Maturation in the ER
Session Chair Ineke Braakman, Utrecht University
7:00PM - 7:30PM Speaker 1, Yair Argon, University of Pennsylvania
“Tuning the magnitude of UPR signaling"
7:30PM – 8:00PM Speaker 2, Linda Hendershot, St. Jude’s Children Research
Hospital
“Chaperone-mediated Protein Maturation in the ER”
8:00PM – 8:15PM Short Talk Selected From Submitted Abstracts
8:15PM – 8:30PM Break
8:30PM – 8:45PM Short Talk Selected From Submitted Abstracts
8:45PM – 9:15PM Speaker 3, Neil Bulleid, University of Glasgow, UK
“Redox changes during ER stress”
9:15PM – 9:45PM Speaker 4, Liz Miller, Columbia University
"Getting out of the ER"

Tuesday June 18, 2013
7:30AM – 9:00AM Breakfast
Session 3
9:00AM – 12:15PM
Structure and Function of the ER
Session Chair Erik Snapp, Albert Einstein College of Medicine
9:00AM - 9:30AM Speaker 1, Will Prinz, National Institutes of Health
“Membrane Contact Sites”
9:30PM –10:00AM Speaker 2, Maho Niwa, University of California San Diego
“NF B and the UPR”
10:00AM – 10:15AM Short Talk Selected From Submitted Abstracts
10:15AM – 10:45AM FASEB Sponsored Coffee Break
10:45AM – 11:15PM Speaker 3, Adabella van der Zand, University of Utrecht,
Netherlands
"The ER as a platform for peroxisome biogenesis"
11:15PM – 12:00PM Speaker 4, Jodi Nunnari, University of California, Davis
"The molecular basis and functions of ER-associated mitochondrial
division"
12:00PM – 12:15PM Short Talk Selected From Submitted Abstracts
12:15PM – 1:15PM
1:15PM – 2:15PM
Lunch
Meet the Experts
Free Afternoon
4:00PM – 6:00PM Poster Session 2
6:00PM – 7:00PM Dinner
Session 4:
7:00PM – 9:45PM
Detecting Unfolded Protein Accumulation
Session Chair Feroz Papa, University of California, San Francisco
7:00PM - 7:30PM Speaker 1, Kenji Kohno, Nara Institute of Science and Technology
(NAIST)
“The distinct roles of IRE1 paralogues in mammalian secretory
cells”
7:30PM – 8:00PM Speaker 2, Nica Borgese, University of Milano
"How the ER adjusts to increased expression of native or mutant
membrane proteins"
8:00PM – 8:15PM Short Talk Selected From Submitted Abstracts
8:15PM – 8:30PM Break
8:30PM – 8:45PM Short Talk Selected From Submitted Abstracts
8:45PM – 9:15PM Speaker 3, David Ron, University of Cambridge, UK
"ER adaptation to unfolded protein load"
9:15PM – 9:45PM Speaker 4, Ron Kopito, Stanford
"Function and organization of the mammalian ERAD pathway”

Wednesday June 19, 2013
7:30AM – 9:00AM Breakfast
Session 5
9:00AM – 12:15PM
Recognizing and Disposing of Misfolded Proteins
Session Chair Liz Miller, Columbia University
9:00AM - 9:30AM Speaker 1, Gisou van der Goot, EPFL-SV-VDG, Switzerland
“Palmitoylation in the ER”
9:30PM –10:00AM Speaker 2, Jeffrey Brodsky, University of Pittsburgh
“Endoplasmic Reticulum Associated Degradation”
10:00AM – 10:15AM Short Talk Selected From Submitted Abstracts
10:15AM – 10:45AM FASEB Sponsored Coffee Break
10:45AM – 11:15PM Speaker 3, Maurizio Molinari, IRB Switzerland
"ERAD tuning"
11:15PM – 12:00PM Speaker 4, Yihong Ye, National Institutes of Health
“Targeting Protein Degradation Pathways in Disease”
12:00PM – 12:15PM Short Talk Selected From Submitted Abstracts
12:15PM – 1:15PM Lunch
Free Afternoon
4:00PM – 6:00PM Poster Session 3
6:00PM – 7:00PM Dinner
Session 6:
7:00PM – 9:45PM
Consequences of Excessive ER Stress
Session Chair Yair Argon, U Penn
7:00PM - 7:30PM Speaker 1, Feroz Papa, University California, San Francisco
"Thioredoxin-Interacting Protein (TXNIP) is an amplifier of the
terminal UPR"
7:30PM – 8:00PM Speaker 2, Hyung Don Ryoo, NYU Langone Medical Center
"UPR and pro-apoptotic Signaling"
8:00PM – 8:15PM Short Talk Selected From Submitted Abstracts
8:15PM – 8:30PM Break
8:30PM – 8:45PM Short Talk Selected From Submitted Abstracts
8:45PM – 9:15PM Speaker 3, Davis Ng, National University of Singapore
"The membrane stress response: remodeling the proteome to
buffer lipid disequilibrium"
9:15PM – 9:45PM Speaker 4, Tom Rutkowski, University of Iowa
"The stress-regulated transcription factor CHOP promotes
hepatocellular carcinoma"

Thursday June 20, 2013
7:30AM – 9:00AM Breakfast
Session 7
9:00AM – 12:15PM
The ER and Cancer
Session Chair Chris Nicchitta, Duke University Medical Center
9:00AM - 9:30AM Speaker 1, Maurizio Zanetti, University of California San Diego
“Cell-extrinsic effects of the tumor UPR on immune cells”
9:30PM –10:00AM Speaker 2, Amy Lee, Keck School of Medicine, USC
“Critical Role of ER chaperone and signaling regulator GRP78/BiP
in tumorigenesis and anti-cancer therapy"
10:00AM – 10:15AM Short Talk Selected From Submitted Abstracts
10:15AM – 10:45AM FASEB Sponsored Coffee Break
10:45AM – 11:15PM Speaker 3, Julio Aguirre-Ghiso, Mount Sinai School of Medicine,
NY
"UPR and autophagy and their connection to tumorigenesis"
11:15PM – 12:00PM Speaker 4, Marianne Koritzinsky, University of Toronto
"Maturation of ER cargo in the tumor microenvironment”
12:00PM – 12:15PM Short Talk Selected From Submitted Abstracts
12:15PM – 12:45PM Business Meeting
12:45PM – 1:45PM Lunch
Free Afternoon
1:00PM – 6:00PM Canoeing, Kayaking, Soccer, Etc.
4:00PM – 6:00PM Poster Session 4
6:00PM – 7:30PM Dinner
Session 8:
7:30PM – 9:30PM
Data Blitz and Hot Topics
Session Chair Ramanujan Hegde, MRC LMB, Cambridge, UK
7:30PM - 8:15PM Selected 5 minute presentations
8:15PM – 8:30PM Break
8:30PM – 9:00PM Speaker 1, Hot Topic TBD
9:00PM – 9:30PM Speaker 2, Hot Topic TBD

Friday June 21, 2013
7:30AM – 8:30AM Breakfast
Session 9
8:30AM – 11:30PM
New pathways in ER Stress
Session Chair David Ron, Cambridge University, UK
8:30AM - 9:00AM Speaker 1, Alejandro Aballay, Duke University Medical Center
"Neural regulation of ER stress pathways during immune activation"
9:00AM – 9:30AM Speaker 2, Jonathan Weissman, University of California, San
Francisco
“Global Analysis of ER Function During Stress"
9:30AM – 9:45AM Short Talk Selected From Submitted Abstracts
9:45AM – 10:00AM Break
10:00AM – 10:15AM Short Talk Selected From Submitted Abstracts
10:15AM – 10:45AM Speaker 3, Doug Cyr, University of North Carolina, Chapel Hill
“Interplay Between Cytosolic Chaperones and ERAD Machinery in
Quality Control of Polytopic Membrane Proteins”
10:45AM – 11:15PM Speaker 4, Patrick Lajoie, Albert Einstein College of Medicine
"Translation Regulation during ER Stress"
11:15AM – 11:30AM Closing Comments
11:30AM Departures
Boxed Lunches Available
END OF CONFERENCE

16 Jun - 21 Jun 2013

Saxtons River
United States of America
meeting website