Proteases in Hemostasis and Vascular Biology

not specified
+ show speakers and program
Sunday, June 2, 2013
4:00PM – 9:00PM FASEB Office open for Registration
6:00PM – 7:00 PM FASEB Opening Reception
7:00PM – 8:30 PM Buffet Dinner
8:30PM – 9:30PM Keynote Speaker
‘What we know -- and don't know -- about how clotting cascades
are initiated’
James Morrissey, U. of Illinois

Monday, June 3, 2013
7:30AM – 9:00AM Breakfast
Session 1: 9:00AM – 12:15PM Protease structure, function and regulation
Chair: Ken Mann, University of Vermont
9:00AM – 9:10AM Welcome to FASEB
9:10AM – 9:40AM Sriram Krishnaswamy, U. Penn
“The Membrane Binding Enigma-New Insights into how Membranes
Regulate Coagulation Enzyme Function”
9:40AM - 10:10AM Paula Tracy, U. Vermont
“Mechanisms Defining Platelets as Procoagulant Machines”
10:10AM –10:25AM (15 min) Short Talk Selected From Submitted Abstracts
10:25AM – 11:00 AM FASEB Sponsored Coffee Break & Group Photo
11:00AM – 11:30AM Jonas Emsley, U. of Nottingham
”Structural studies of coagulation factor XII and the pathway to
contact activation”
11:30AM – 12:00PM F. Xavier Gomis-Ruth, Mol. Biol. Inst. of Barcelona
“Structural studies of human a2-macroglobulin, a pan-protease
inhibitor from blood”
12:00PM – 12:15PM Short Talk Selected From Submitted Abstracts
12:15PM – 1:15PM Lunch
Free Time
3:00PM – 4:00PM Meet-the-Expert Session
4:00PM – 6:00PM Poster Session 1
6:00PM – 7:00PM Dinner
Session 2: 7:00PM – 10:00PM Platelets I
Chair: JoAnn Trejo, UCSD
7:00PM - 7:30PM Skip Brass, University of Pennsylvania
“Configuring the platelet signaling network to produce an
optimal response to vascular injury”
7:30PM – 8:00PM Jose Lopez,Puget Sound Blood Center
“Regulation of von Willebrand factor self-association and
activity”
8:00PM – 8:15PM Short Talk Selected From Submitted Abstracts
8:15PM – 8:45PM Break
8:45PM – 9:15PM Debra Newman, Blood Research Institute of Wisconsin
“Inhibitory receptor signaling in inflammation and thrombosis”
9:15PM – 9:45PM Leslie Parise, UNC
“Competitive Activity-Based Protein Profiling in Platelet Target
Discovery”
9:45PM – 10:00PM Short Talk Selected From Submitted Abstracts

Tuesday, June 4, 2013
7:30AM – 9:00AM Breakfast
Session 3: 9:00AM – 12:15PM Genetics and O’Mics
Chair: Charles Craik, UCSF
9:00AM - 9:30AM Frits Rosendaal, Leids University
“Genetics of venous thrombosis”
9:30PM –10:00AM Andrew Gale, Scripps
“Proteomic analysis of the coagulation degradome”
10:00AM – 10:15AM Short Talk Selected From Submitted Abstracts
10:15AM – 10:45AM FASEB Sponsored Coffee Break
10:45AM – 11:15AM Monika Stoll, Leibniz University “Role of ADAMTS gene family in
the genetic predisposition to stroke”
11:15AM – 11:45AM Charles Craik, UCSF
“Non-Invasive Imaging of Thrombin Activity by Near-Infrared
Fluorescence and Positron Emission Tomography”
11:45AM – 12:00PM Short Talk Selected From Submitted Abstracts
12:00PM – 1:00PM Lunch
Afternoon free for activities
6:00PM – 7:00PM Dinner
7:00PM – 8:00PM Stuart Stone Lecture
Denisa Wagner, Harvard
“NETs: Linking inflammation and thrombosis”
Session 4: 8:00PM – 10:00PM Collagen and more
Chair: Denisa Wagner, Harvard
8:00PM - 8:30PM Richard Farndale, Univ. of Cambridge
“Triple-helical peptides: probes for MMPs and other collagenbinding
targets in the vessel wall”
8:30PM – 9:00PM Break
9:00PM – 9:30PM Ulrich Baumann, U. of Cologne
“Folding and holding the collagen triple helix: Insights from the
Hsp47:collagen model peptide crystal structure”
9:30PM – 10:00PM Hot Topic (selected from abstracts)

Wednesday,
June 5, 2013
7:30AM – 9:00AM Breakfast
Session 5: 9:00AM – 12:00PM vWF, TTP and proteases
Chair: Flora Peyvandi, Milan
9:00AM - 9:30AM Karen Vanhoorelbeke, KU Leuven
“Relationship between ADAMTS13 and VWF in thrombotic
thrombocytopenic”
9:30PM –10:00AM Vincenzo De Filippis, Padua
“Effects of Met1606 Oxidation on von Willebrand Factor Proteolysis
by ADAMTS13 and Leukocyte Serine Proteases”
10:00AM – 10:15AM Short Talk Selected From Submitted Abstracts
10:15AM – 10:45AM FASEB Sponsored Coffee Break
10:45AM – 11:15AM Flora Peyvandi, Milan
“The ADAMTS13 metalloprotease in hemostasis”
11:15AM – 11:45AM Nigel Mackman, UNC
“Role of PAR-1 in the innate immune response to viral infection”
11:45PM – 12:00PM Short Talk Selected From Submitted Abstracts
12:00PM – 1:00PM Lunch
Free Time
4:00PM – 6:00PM Poster Session 2
6:00PM – 7:00PM Dinner
7:00PM – 7:15PM Business Meeting
Session 6: 7:15PM – 10:00PM Clot Structure and Dissolution
Chair: Alisa Wolberg, UNC
7:15PM - 7:45PM Kathy Hajjar, Cornell
“The Annexin A2 System in Vascular Health and Disease”
7:45PM – 8:15PM Robert Ariëns, Leeds University
“Regulation of fibrin structure and its role in thrombosis”
8:15PM – 8:30PM Short Talk Selected From Submitted Abstracts
8:30PM – 9:00PM Break
9:00PM – 9:30PM John Weisel, UPenn
“Clot mechanical properties and remodeling without proteolysis”
9:30PM – 10:00PM Timothy Stalker, UPenn
“The core of the clot”

Thursday,
June 6, 2013
7:00AM – 9:00AM Breakfast
Session 7: 9:00AM – 12:00PM Tissue Factor
Chair: Wolfram Ruf, Scripps
9:00AM - 9:30AM Florea Lupu, OMRF
“Crosstalk between coagulation and complement systems in
sepsis”
9:30AM –10:00AM James Luyendyk, Michigan State University
“Hepatocyte tissue factor: A match in a dynamite factory!”
10:00AM – 10:15AM Short Talk Selected From Submitted Abstracts
10:15AM – 10:45AM FASEB Sponsored Coffee Break
10:45AM – 11:15AM Alan Mast , BloodCenter of Wisc.
“Recent advances in our understanding of TFPI isoform expression
and anticoagulant function”
11:15AM – 11:45M Tilman Hackeng, Maastrict Univ.
“Modular requirements of TFPI function”
11:45AM – 12:00PM Short Talk Selected From Submitted Abstracts
12:00PM – 1:00PM Lunch
Afternoon free for activities
6:00PM – 7:00PM Dinner
Session 8: 7:00PM – 10:00PM Platelets II
Chair: Susan Smyth, Univ. of Kentucky
7:00PM - 7:30PM Mark Ginsberg, UCSD
“Dynamic Regulation of Vascular Cell Adhesion”
7:30PM – 8:00PM Cheng Zhang, Stanford
“Structural insights into the signaling and pharmacology of PAR1”
8:00PM – 8:15PM Short Talk Selected From Submitted Abstracts
8:15PM – 8:45PM Break
8:45PM – 9:15PM Martine Jandrot-Perrus, INSERM
“Platelet serpinE2/protease nexin-1: role in thrombosis and
thrombolysis”
9:15PM – 9:45PM Mortimer Poncz, U. Penn
“Platelet targeted thrombolytics: Inside and surface strategies”
9:45PM – 10:00PM Short Talk Selected From Submitted Abstracts

Friday, June 7, 2013
7:30AM – 9:00AM Breakfast
Session 9: 9:00AM – 11:05AM Drug Developments: current treatments and unmet needs
Chair: Hartmut Weiler, BloodCenter of Wisc.
9:00AM - 9:30AM Jeffrey Weitz, McMaster University, Canada
“New anticoagulants, new opportunities”
9:30AM – 10:00AM Susan Smyth, Univ. of Kentucky
“The latest in anti-platelets”
10:00AM – 10:30AM Break
10:30AM – 11:00AM TBD
11:00AM – 11:05AM Closing Comments
12:00PM Departure
Boxed Lunches Available

2 Jun - 7 Jun 2013
Nassau
Bahamas
meeting website