Neurobiology of Cognition

Recent advances have ushered in a new era for neurobiological studies of complex cognitive functions beyond early sensory processing. Human studies using fMRI and electromagnetic measures have identified brain systems and large scale dynamics important for memory, attention, decision making, emotion regulation, and other aspects of cognition. Neurophysiological studies in nonhuman subjects have discovered neural underpinnings of many of these same cognitive functions. Computational models have been developed to elucidate the dynamics and cellular/ensemble properties of the underlying neural networks. Along with continuing rapid progress in each of these traditional areas, there is accelerated progress in neuronal recording studies in monkeys and rodents targeting other high level processes such as task switching and executive control, which were previously only rarely investigated outside of human studies. There is also increasing attention paid to neuronal dynamics such as oscillations and continuing lively debate on whether and how they may contribute to the brain operations underlying cognition. Relevant to all of these issues, recent application of novel experimental and theoretical approaches are beginning to uncover general principles of the networks that guide cognition at a fundamental level. These advances hold the promise of effectively blending molecular and circuit neurobiology with cognitive neurosciences. Findings in this field have begun to provide important insights into the neural bases of normative cognitive function as well as how disruption of these functions underlie a variety of mental disorders.

This recently inaugurated Gordon Conference series provides a forum for researchers and students to exchange data and discuss ideas on cutting-edge issues in the neurobiology of cognition. Given the broad field, each meeting has a somewhat different focus, to facilitate in-depth discussions and at the same time preserve the breadth. The program and format of the meeting are designed to foster intense interactions among investigators from different fields (e.g., between cognitive neuroscientists using human fMRI and neurophysiologists working with behaving animals) or across levels (from cellular and subcellular physiology, microcircuits, to large-scale brain systems), as well as between experimentalists and theorists.

+ show speakers and program
4:00 pm - 8:00 pm Arrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pm Dinner
7:30 pm - 7:40 pm Welcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pm Oscillations: How do they contribute to cognition?
Discussion Leader: Bob Desimone (MIT)
7:40 pm - 8:30 pm Keynote Speaker: Wolf Singer (Max Planck, Frankfurt)
"Dynamic Coordination of Functional Networks in the Cerebral Cortex: Mechanisms, Development and Psychiatric Diseases"
8:30 pm - 8:45 pm Discussion
8:45 pm - 9:15 pm Jessica Cardin (Yale University)
"Inhibitory Regulation of Cortical Networks"
9:15 pm - 9:30 pm Discussion
9:30 pm - 11:00 pm Informal Social
MONDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Active Sensing
Discussion Leader: Charles Schroeder (Columbia University)
9:00 am - 9:30 am Robert Desimone (MIT)
"Prefrontal-Visual Cortex Interactions with Attention"
9:30 am - 9:45 am Discussion
9:45 am Group Photo / Coffee Break
10:15 am - 10:45 am Marc Sommer (Duke University)
"Neuronal Circuits for Presaccadic Visual Remapping"
10:45 am - 11:00 am Discussion
11:00 am - 11:30 am David Kleinfeld (University of California, San Diego)
"Neuronal Basis for Object Location in a Scanning Sensorimotor System"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pm Christoph Kayser (Max Planck Institute, Tuebingen)
"How Vision Enhances Hearing - Studies on Multisensory Processing in the Temporal Lobe"
12:15 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 5:30 pm Free Time
5:30 pm - 7:30 pm Systems Connections
Discussion Leader: Earl Miller (MIT)
5:30 pm - 5:55 pm Pascal Fries (Ernst Strüngmann Institute, Frankfurt)
"Attentional Selection through Selective Interareal Synchronization"
5:55 pm - 6:10 pm Discussion
6:10 pm - 6:35 pm Stephanie Clarke (University of Vaudois, Lausanne)
"Connectivity and Plasticity within Auditory Processing Streams"
6:35 pm - 6:50 pm Discussion
6:50 pm - 7:15 pm Olaf Sporns (Indiana University)
"Network Architecture of Large-Scale Brain Connectivity"
7:15 pm - 7:30 pm Discussion
8:00 pm Dinner
TUESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Temporal Lobe Memory
Discussion Leader: John O'Keefe (University College, London)
9:00 am - 9:30 am May-Britt Moser (NTNU, Trondheim)
"Brain Maps for Space"
9:30 am - 9:45 am Discussion
9:45 am Coffee Break
10:15 am - 10:45 am A. David Redish (University of Minnesota)
"Deliberation in the Rodent - Just How Vicarious is that 'Vicarious Trial and Error' (VTE) Behavior?"
10:45 am - 11:00 am Discussion
11:00 am - 11:30 am Jill Leutgeb (UCSD)
"Parallel Processing in Neural Circuits for Space and Memory"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pm Eleanor Maguire (University College, London)
"Relating Space and Memory in the Temporal Lobes"
12:15 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 5:30 pm Poster Session
5:30 pm - 7:30 pm Aging Circuits
Discussion Leader: Lynn Nadel (University of Arizona)
5:30 pm - 5:55 pm Scott Small (Columbia University)
"Dissecting the Aging Hippocampal Circuit with Neuroimaging"
5:55 pm - 6:10 pm Discussion
6:10 pm - 6:35 pm Mark D'Esposito (University of California, Berkeley)
"Revisiting Dedifferentiation as a Neural Mechanism Underlying Cognitive Aging"
6:35 pm - 6:50 pm Discussion
6:50 pm - 7:15 pm Cheryl Aine (University of New Mexico)
"So What is Aging, Really?"
7:15 pm - 7:30 pm Discussion
8:00 pm Dinner
WEDNESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Decision Making
Discussion Leader: Tatiana Pasternak (University of Rochester)
9:00 am - 9:30 am Daeyeol Lee (Yale University)
"Primate Prefrontal Cortex and Decision Making"
9:30 am - 9:45 am Discussion
9:45 am Coffee Break
10:15 am - 10:45 am Trevor Robbins (University of Cambridge)
"Neural and neurochemical decomposition of decision-making cognition in humans and other animals"
10:45 am - 11:00 am Discussion
11:00 am - 11:30 am Leslie Fellows (McGill University, Montreal)
"Prefrontal Contributions to Value-Based Learning and Decision-Making: Evidence from Humans with Frontal Lobe Damage"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pm Xiao-Jing Wang (Yale University)
"Neural Circuit Mechanisms of Speed-Accuracy Tradeoff in Flexible Decision-Making"
12:15 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 5:30 pm Poster Session
5:30 pm - 7:30 pm Molecular Tools for Circuit Manipulation
Discussion Leader: Edvard Moser (NTNU, Trondheim)
5:30 pm - 6:20 pm Keynote Speaker: Karl Deisseroth (Stanford University)
"Optogenetics: Development and Application"
6:20 pm - 6:35 pm Discussion
6:35 pm - 7:15 pm Ehud Isacoff (University of California, Berkeley)
"Manipulation of Brain Glutamate Receptors and Plasticity with Light"
7:15 pm - 7:30 pm Discussion
7:30 pm - 8:00 pm Business Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
8:00 pm Dinner
THURSDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Social Cognition
Discussion Leader: Aina Puce (University of Indiana)
9:00 am - 9:30 am TBA
9:30 am - 9:45 am Discussion
9:45 am Coffee Break
10:15 am - 10:45 am Rebecca Saxe (MIT)
"It's the Thought that Counts: Neural Signatures of Thinking About Thoughts"
10:45 am - 11:00 am Discussion
11:00 am - 11:30 am Ralph Adolphs (CalTech)
"Studies of the Human Amygdala: fMRI, Single-Unit, and Lesion Studies"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pm Michael Platt (Duke University)
"Separate Channels for Self and Other Reward in Primate Prefrontal Cortex"
12:15 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 5:30 pm Free Time
5:30 pm - 7:30 pm Molecular Genetics and Disease
Discussion Leader: Robert Knight (University of California, Davis)
5:30 pm - 5:55 pm Dan Geschwind (University of California, Los Angeles)
"Gene Networks Dysregulated in Autism"
5:55 pm - 6:10 pm Discussion
6:10 pm - 6:35 pm Alcino Silva (University of California, Los Angeles)
"Molecular, Cellular and Systems Mechanisms of Memory Allocation"
6:35 pm - 6:50 pm Discussion
6:50 pm - 7:15 pm TBA
7:15 pm - 7:30 pm Discussion

8 Jul - 13 Jul 2012
Lucca
Italy
meeting website