Notch Signaling in Development, Regeneration & Disease

The goal of the proposed Gordon Research Conference on Notch signaling in development, regeneration and disease is to provide a stimulating, international and cross disciplinary forum for the dissemination and discussion of new research, concepts and therapeutic opportunities at the forefront of Notch related biology. The Notch signaling pathway is a central mediator of short-range inter-cellular communication in metazoans, under study since 1914 in Drosophila, and in all other model organisms since the 1980s. Alteration in Notch activity underlie or contribute to a growing list of developmental syndroms (Alagille, Spondylocostal Dysostosis, aortic valve disease), adult onset diseases (CADASIL, Alzheimer's disease, various heart and valve malformations, muscular dystrophy, multiple sclerosis) and cancers, expending the interest in this pathway well beyond scientists interested in developmental and cell biology to those interested in stem cells, cancer biology and therapy. The meeting will bring together a diverse community of scientists working in every model organism and on nearly every organ system from academia, biotech and the pharmaceutical industry. We aim to create a forum in which cutting edge technologies, ideas and discoveries can be exchanged. Most importantly, we aim to integrate students and postdocs in this academically intense and free environment into the study of Notch signaling.

+ show speakers and program
2:00 pm - 9:00 pm Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pm Dinner
7:30 pm - 7:35 pm Welcome / Introductory Comments by GRC Site Staff
7:35 pm - 9:30 pm Life Around Notch
Session Chair and Discussion Leader: Rafi Kopan
7:35 pm - 8:05 pm David Holtzman (Washington University)
"Advances in the early diagnosis and treatment of Alzheimer's disease"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:45 pm Yuh-Nung Jan (UCSF)
"Life after Notch: control of dendrite development, neuronal morphogenesis and their functional implications"
8:45 pm - 9:00 pm Discussion
9:00 pm - 9:25 pm Olivier Pourquie (IGBMC)
"Somitogenesis"
9:25 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm The Cell Biology Of Notch Signaling
Session Chair and Discussion Leader: Francois Schweisguth (Pasteur,FR)
9:00 am - 9:20 am Ryoichiro Kageyama (Institute for Virus Research Kyoto)
"Hes1 oscillation in neural stem cell differentiation"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am David Sprinzak (TAU, Israel)
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am Hugo Bellen (Baylor)
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Martin Baron (University of Manchester)
"Endocytic regulation of alternate routes to Notch activation"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am Thomas Vaccari (IFOM-IEO, Milan)
"Control of Notch signaling activation at the endosome"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pm Gerry Weinmaster (UCLA)
"Roles for ligand endocytosis and mechanical force in Notch signaling"
12:20 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm Notch in Vascular Biology
Session Chair and Discussion Leader: TBA
7:30 pm - 7:50 pm Holger Gerhardt (MRC)
"Time to branch? - Dynamic patterning of vascular networks by Notch"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Ralf Adams (University of M√ľnster)
"Notch signaling in the vasculature"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Yoshiko Takahashi (Nara Institute of Science and Technology)
"Dynamic cell rearrangements during vascular development"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Michael Potente (Goethe University)
"Controlling the dynamics of endothelial Notch signaling - the sirtuin connection"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Notch in Stem and Progenitor Cells
Session Chair and Discussion Leader: Anna Bigas (Barcelona)
9:00 am - 9:20 am Taka Maeda (City of Hope)
"Notch suppression by LRF in adult HSC maintenance and lymphoid lineage fate determination"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Irma Conboy (UCSF)
"How do muscle stem cells know where and when to wake up?"
9:50 am - 10:00 am Discussion
10:00 am Group Photo / Coffee Break
10:30 am - 10:50 am Andy Groves (Baylor)
"The role of Notch signaling in sensory hair cell development and regeneration"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Ben Ohlstein (Columbia)
"Notch in the drosophila adult stem cell niche"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am Tim Schedl (Washington University)
"GLP-1 signaling specifies the germline proliferative cell fate in C. elegans"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pm Paolo Dotto
12:20 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm Regulating Notch Activity in Disease
Session Chair and Discussion Leader: TBA
7:30 pm - 7:50 pm Chris Seibel (Genentech)
"Therapeutic Modulation of Notch Signaling using Monoclonal Antibodies"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Gavin Thurston (Regeneron)
"The role of Dll4-Notch signaling in tumor angiogenesis"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Christy Fryer (Novartis)
"Screening for inhibitors of Notch signaling"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Yibin Kang (Princeton)
"Notch signaling in breast cancer metastasis"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Immunology
Session Chair and Discussion Leader: TBA
9:00 am - 9:20 am Shahin Raffi (Cornell)
"Vascular niche mediates regeneration of Notch-dependent stem cells"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Freddy Radtke (SIECR, Lausanne)
"Anti-tumor activity induced by loss of Notch proteins in the epidermis"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am Ivan Maillard (Michigan)
"Notch signaling in alloimmunity"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Iannis Aifantis (NYU)
"Visualization and lineage tracing of Notch activity in hematopoieisis"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am Jon Aster (Harvard)
"Notch regulation of gene expression in T cell leukemia"
11:50 am - 12:00 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:00 pm - 7:30 pm Business Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pm Issues Arising Session
Session Chair and Discussion Leader: Alain Israel (Pasteur)
7:30 pm - 7:50 pm Alfonso Martinez Arias (Cambridge)
"Structure and function of Wntch signaling in development"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:10 pm TBA (Selected from Abstract Pool)
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:25 pm TBA (Selected from Abstract Pool)
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:40 pm TBA (Selected from Abstract Pool)
8:40 pm - 8:45 pm Discussion
8:45 pm - 8:55 pm TBA (Selected from Abstract Pool)
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:10 pm TBA (Selected from Abstract Pool)
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm TBA (Selected from Abstract Pool)
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Transcription, Chromatin and Notch
Session Chair and Discussion Leader: Irv Bernstein (Fred Hutchinson Cancer Research Center)
9:00 am - 9:20 am Adolfo Ferrando (Colombia University)
"NOTCH signaling in lymphoid development and transformation"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Warren Pear (Penn)
"Notch targets in T-ALL"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am Brad Bernstein (Harvard)
"Notch - Chromatin Collaborations in Cancer"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Sarah Bray (Cambridge)
"Decoding the notch signal"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am Jane Johnson (UTSW)
"Notch independent function of Rbpj in Neuronal Subtype Specification"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:10pm TBA (Selected from Abstract Pool)
12:10 pm - 12:15 pm Discussion
12:15 pm - 12: 25pm TBA (Selected from Abstract Pool)
12:25 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm Structural Analysis of Components in the Notch Signaling Pathway
Session Chair and Discussion Leader: Doug Barrick (John Hopkins)
7:30 pm - 7:50 pm Rhett Kovall (Cincinnati)
"Structure and function of Notch transcription complexes"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Penny Handford (University of Oxford)
"Molecular basis of Notch-ligand interactions"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Pamela Stanley (Einstein)
"Roles for Glycans in Notch Signaling"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Hamad Jafar-Nejad (MD Anderson)
"Regulation of Notch signaling by O-glycans"

12 Aug - 17 Aug 2012
Lewiston
United States of America
meeting website