Cell Senescence in Cancer and Ageing

Cell senescence is a stable arrest of proliferation initiated by a variety of molecular triggers, including activated oncogenes and excess rounds of cell division.In addition, senescent cells secrete a cocktail of inflammatory and stromal regulators (the senescence-associated secretory phenotype) that influences the behaviour of neighbouring cells, including immune cells. Compelling evidence now indicates that cell senescence is a potent tumour suppression mechanism. At the same time, senescence likely contributes to tissue and organismal ageing.

This exciting new conference will bring together senior and junior researchers investigating mechanisms of cell senescence, the impact of senescence on cancer and ageing and avenues to exploit senescence in cancer and disease therapies.

+ show speakers and program
Conference Programme

Saturday, 20 July
15.00 – 16.20 Registration
16:20 - 16:30 Welcome and Introduction
Dorothy C Bennett, St George's, University of London, UK
16.30 – 17.30 Keynote talk 1
Introduced by Peter Adams, Beatson Institute for Cancer Research and University of Glasgow, UK
Judith Campisi: The Buck Institute for Research on Aging & Lawrence Berkeley National Laboratory, California
17.30 – 17.45 Break
17.45 – 19.15 Session 1 - Molecular mechanisms of cell senescence I
Chairs: TBC
17.45 – Molecular mechanisms of cellular senescence
Fabrizio d'Adda di Fagagna,
FIRC Institute of Molecular Oncology, Italy
18.15 - Abstract talk 1
18.30 - Abstract talk 2
18.45 – Interactions between positive feedback loops in cell senescence
Thomas Von Zglinicki
19.15 – 21.00 Welcome reception drinks and dinner

Sunday, 21 July
07.30 – 09.00 Breakfast
09.00 - 10.30 Session 2 - Molecular mechanisms of cell senescence II
Chairs: TBC
09.00 – Chromatin structure and gene regulation in oncogene-induced senescence
Masashi Narita,
Cambridge Research Institute, UK
09.30 - Abstract talk 1
09.45 - Abstract talk 2
10.00 – Epigenome meets Senescence: Dynamics of Noncoding RNAs and Chromatin Organizers in Transcriptional Regulation.
Oliver Bischof, Pasteur Institute, France
10.30 – 11.00 Morning coffee
11.00 – 12.30 Session 3 - Molecular mechanisms of cell senescence III
Chairs: TBC
11.00 - Cellular senescence and NF-kB signalling, Parmjit Jat - Institute of Neurology, University College London, UK
11.30 - Abstract talk 1
11.45 - Abstract talk 2
12.00 – A complex secretory response orchestrated by the inflammasome
controls paracrine senescence,Jesús Gil- MRC Clinical Sciences Centre, UK
12.30 – 14.00 Lunch & Posters
14.00 – 15.00 Keynote talk 2 Introduced by Parmjit Jat, Institute of Neurology, University College London, UK
Jerry Shay: UT Southwestern Medical Center, Texas, USA
15.00 – 16.30 Session 4 – Phenotypes and functions of senescence
Chairs: TBC
15.00 - Cell senescence: a flawed tumor suppressor mechanism?
Peter Adams,
Beatson Institute for Cancer Research and University of Glasgow, UK
15.30 - Abstract talk 1
15.45 - Abstract talk 2
16.00 -
Lars Zender,
University Hospital Tübingen, Germany
16.30 – 17.00 Afternoon tea
17.00 – 19.00 Poster session
19.00 – 20.30 Dinner
20.30 – 21.30 ECSA assembly

Monday, 22 July
07.30 – 09.00 Breakfast
09.00 - 10.30 Session 5 – Senescence, stem cells and ageing I
Chairs: TBC
09.00 - Skin aging: a role for fibroblast senescence?
Petra Boukamp,
German Cancer Research Centre, Germany
09.30 - Abstract talk 1
09.45 - Abstract talk 2
10.00 - Whole genome iRNA screening identifies aneuploidy-inducing gene knockdowns and telomerase-activation as an aneuploidy survival mechanism in human cells
Lenhard Rudolph, Institute of Molecular Medicine, Germany
10.30 – 11.00 Morning coffee
11.00 – 12.30 Session 6 - Senescence, stem cells and ageing II
Chairs: TBC
11.00 - Global epigenetic changes and derepression of transposable elements in replicative senescence
John Sedivy,
Brown University, USA
11.30 - Abstract talk 1
11.45 - Abstract talk 2
12.00 - The mitotic checkpoint protein BubR1 in Senescence, Cancer and Aging
Jan van Deursen, Mayo Clinic College of Medicine, Rochester, USA
12.30 – 14.00 Lunch & Posters
14.00 – 15.00 Keynote talk 3 Introduced by Dorothy Bennett, St George's, University of London, UK.
Senescence in cancer, aging and ... also development.
Manuel Serrano
National Cancer Research Centre, Spain
15.00 – 16.30 Session 7 – Senescence and cancer I
Chairs: TBC
15.00 – Senescence and melanoma development
Daniel Peeper, Netherlands Cancer Institute, Netherlands
15.30 - Abstract talk 1
15.45 - Abstract talk 2
16.00 – Gene expression in melanocyte senescence and melanoma
Dorothy C Bennett, St George's, University of London, UK
16.30 – 17.00 Afternoon tea
17.00 – 18.30 Session 8 – Open Forum. What is Cell Senescence?
Chairs: John Sedivy & Jerry Shay
All speakers and attendees can participate
19.00 – 22.00 Conference Dinner & Poster Prizes

Tuesday, 23 July
07.30 – 09.00 Breakfast
09.00 - 10.30 Session 9 – Senescence and cancer II
Chairs: TBC
09.00 –
Xin Lu,
Ludwig Institute for Cancer Research, Oxford, UK
09.30 - Abstract talk 1
09.45 - Abstract talk 2
10.00 - Role of FoxM1 in cancer therapy, DNA damage and senescence
Eric Lam, Imperial College London, UK
10.30 – 11.00 Morning coffee
11.00 – 12.30 Session 10 - Therapeutic applications of senescence
Chairs: TBC
11.00 - Screening strategies to unlock targets for senescence drug discovery
Nicol Keith,
Beatson Institute for Cancer Research, UK
11.30 - Abstract talk 1
11.45 - Abstract talk 2
12.00 - Janus-faced senescence in cancer therapy
Clemens Schmitt, Max-Delbrück-Center for Molecular Medicine (MDC)
12.30 – 14.00 Lunch & depart


Keynote speakers
Prof Judith Campisi, The Buck Institute for Research on Aging & Lawrence Berkeley National Laboratory, CA, USA
Dr Manuel Serrano, National Cancer Research Centre, Spain
Dr Jerry Shay, UT Southwestern Medical Center, TX, USA

International Scientific Programme Committee speakers
Prof Petra Boukamp, German Cancer Research Centre, Germany
Dr Fabrizio d'Adda di Fagagna, FIRC Institute of Molecular Oncology, Italy
Prof Xin Lu, Ludwig Institute for Cancer Research, Oxford
Prof Daniel Peeper, Netherlands Cancer Institute, Netherlands
Prof John Sedivy, Brown University, USA

Additional invited speakers
Dr Oliver Bischof, Pasteur Institute, France
Dr Jesús Gil, Imperial College London, UK
Prof Nicol Keith, Beatson Institute for Cancer Research, UK
Prof Eric Lam, Imperial College London, UK
Dr Masashi Narita, Cambridge Research Institute, UK
Prof Clemens Schmitt, Max-Delbrück-Center for Molecular Medicine (MDC), Germany
Dr Jan van Deursen, Mayo Clinic College of Medicine, Rochester, USA
Prof Lars Zender, University Hospital Tuebingen, Germany
Prof. Dr Lenhard Rudolph, Institute of Molecular Medicine, Germany
Prof Thomas von Zglinicki, Institute for Ageing and Health, Newcastle University, UK


20 Jul - 23 Jul 2013
Cambridge
United Kingdom
meeting website