2013 American Society for Biochemistry and Molecular Biology Meeting

SCIENTIFIC SESSIONS

Catalytic Mechanisms
Chemical and Systems Biology
Genome Replication and Repair
Glycan Regulation of Signaling Pathways
Lipids and Membranes
Mechanisms of Gene Transcription and Regulation
Mechanisms of Signal Transduction
Protein Modification, Trafficking and Degradation
RNA Function and Protein Synthesis
Triple Negative Breast Cancer


+ show speakers and program
2013 ASBMB ANNUAL MEETING PROGRAM

ASBMB Award & Plenary Lectures

2013 ASBMB AWARD LECTURES

HERBERT TABOR RESEARCH AWARD, Saturday, April 20, 6:00 p.m.
Boston Convention and Exhbition Center (BCEC), West Ballroom
F. Ulrich Hartl, Max Planck Institute for Biochemistry
Molecular chaperones in cellular protein folding: mechanisms and pathways


Arthur L. Horwich, HHMI/Yale School of Medicine
Chaperonin-mediated protein folding


AVANTI AWARD IN LIPIDS, Sunday, April 21 • 8:30 – 9:05 a.m.
BCEC, Room 258, Level Two - East
Susan A. Henry, Cornell University
The dynamic roles of phospholipid and triacylglycerol metabolism in regulation and signaling in yeast


RUTH KIRSCHSTEIN DIVERSITY IN SCIENCE AWARD, Sunday, April 21 • 9:05 – 9:40 a.m
BCEC, Room 258, Level Two - East
Peter Blumberg, National Institutes of Health
Natural products as powerful tools for drug discovery: insights from the phorbol esters


ASBMB AWARD FOR EXEMPLARY CONTRIBUTIONS TO EDUCATION, Sunday, April 21 • 12:30–1:05 p.m.
BCEC, Room 257, Level Two - East
James M. Ntambi, University of Wisconsin – Madison
From the classroom to communities: Connecting students in the sciences to real-world situations


WILLIAM C. ROSE AWARD, Sunday, April 21 • 2:55 – 3:30 p.m.
BCEC, Room 258, Level Two - East
Ivan Dikic, Goethe University School of Medicine
Decoding Ubiquitin Networks in regulation of inflammation and autophagy


ASBMB YOUNG INVESTIGATOR AWARD, Monday, April 22 • 8:30 – 9:05 a.m.
BCEC, Room 258, Level Two - East
Shu-ou Shan, California Institute of Technology
GTPase and ATPase tangos during intracellular protein targeting


ASBMB-MERCK AWARD, Monday, April 22 • 9:05 – 9:40 a.m.
BCEC, Room 258, Level Two - East
Vivek Malhotra, Centre for Genomic Regulation
Biogenesis of transport carriers


ALICE AND C.C. WANG AWARD IN MOLECULAR PARASITOLOGY AND SYMPOSIUM
Monday, April 22 • 12:30-2:30 p.m., BCEC, Room 258, Level Two - East

Daniel E. Goldberg, HHMI/Washington University School of Medicine in St. Louis
Amino acid utilization in intraerythrocytic malaria parasites

Additional symposium presenters:
Audrey R. Odom, Washington University School of Medicine
Scent of a parasite: isoprenoids in malaria
Boris Striepen, University of Georgia
What do human parasites do with a chloroplast anyway?



DELANO AWARD FOR COMPUTATIONAL BIOSCIENCES, Monday, April 22 • 2:55 – 3:30 p.m.
BCEC, Room 258, Level Two - East
Helen M. Berman, Rutgers University
PDB as a public resource for enabling protein science


ASBMB PLENARY LECTURE, Tuesday, April 23 • 8:30 – 9:05 a.m.
BCEC, Room 258, Level Two - East
Melanie Cobb, University of Texas Southwestern Medical Center
ERKonomics: MAPK assets and liabilities


EARL AND THRESSA STADTMAN DISTINGUISHED SCIENTIST AWARD, Tuesday, April 23 • 9:05–9:40 a.m.
BCEC, Room 258, Level Two - East
Brian K. Kobilka, Stanford University School of Medicine
Structural insights into the dynamic process of G-protein–coupled receptor activation


FRITZ LIPMANN LECTURESHIP, Tuesday, April 23 • 2:55 – 3:30 p.m.
BCEC, Room 258, Level Two - East
Olke C. Uhlenbeck, Northwestern University
Tuning tRNA Sequences for Optimal Translation



WALTER A. SHAW YOUNG INVESTIGATOR AWARD IN LIPID RESEARCH, Tuesday, April 23 • 3:45–4:20 p.m.,
lecture scheduled within the symposium Lipid Trafficking and Sorting
BCEC, Room 254, Level Two - East
Tobias Walther, Yale School of Medicine
Cell biology of neutral lipid storage


MILDRED COHN AWARD IN BIOLOGICAL CHEMISTRY, Wednesday, April 24 • 9:00 – 9:35 a.m.
BCEC, Room 258, Level Two - East
Jennifer A. Doudna, HHMI/University of California, Berkeley
Defending the Genome: Regulatory RNA in Humans and Bacteria



SCIENTIFIC SESSIONS:

Catalytic Mechanisms

Theme Organizers
Enrique De La Cruz, Yale Univ and
Catherine Drennan, MIT

Three (3) volunteered talks per session will be selected from the abstracts submitted to ASBMB topic categories #2000-2408, by the November 13 deadline.

Bioenergy
Sunday, April 21, 2013, 3:45 pm - 6:00 pm
Room 253 "C", Level Two - East
Session Chair JoAnne Stubbe, MIT

Water oxidation chemistry of photosystem II
Gary W. Brudvig, Yale Univ

Crystallographic snapshots of metalloenzyme complexes involved in biological carbon dioxide sequestration
Catherine Drennan, MIT

Biogenesis of the H-cluster of the [FeFe]-hydrogenase
Joan Broderick, Montana State Univ

Catalytic and Substrate Promiscuity
Monday, April 22, 2013, 9:55 am - 12:10 pm
Room 253 "C", Level Two - East
Session Chair Shelley D. Copley, Univ of Colorado, Boulder

Multiple catalytic promiscuity: specificity and efficiency in the alkaline phosphatase superfamily
Florian Hollfelder, Univ of Cambridge

Enzyme recruitment and the evolution of new metabolic potential
Brian G. Miller, Florida State Univ

The remarkable pliability and promiscuity of specialized metabolism
Joseph P. Noel, HHMI/Salk Inst for Biological Studies

Cool Catalysis and Radically New Reaction Mechanisms
Tuesday, April 23, 2013, 3:45 pm - 6:00 pm
Room 253 "C", Level Two - East
Session Chair Joan Broderick, Montana State Univ

Novel enzymatic transformations in secondary metabolism and tRNA modification
Vahe Bandarian, Univ of Arizona

Investigating Roles of Reader Domains in Regulating Activity of Jumonji Histone Demethylases
Danica Fujimori, UCSF

Radicals: Your life is in their hands
JoAnne Stubbe, MIT

Molecular Motor Proteins - Force and Work as Products
Wednesday, April 24, 2013, 9:55 am - 12:10 pm
Room 253 "C", Level Two - East
Session Chair Enrique M. De La Cruz, Yale Univ

ATP utilization by DExD/H-box RNA helicases – molecular motor proteins that couple ATPase activity with RNA rearrangement.
Enrique M. De La Cruz, Yale Univ

Kinesins - How the ATPase cycle modulates function
Susan P. Gilbert, Rensselaer Polytechnic Inst

From force-sensing to power generation - How force modulates the ATPase kinetics of myosin motors
E. Michael Ostap, Univ of Pennsylvania


Chemical and Systems Biology

Theme Organizers
Shelley D. Copley, Univ of Colorado, Boulder and
Anna K. Mapp, Univ of Michigan

Three (3) volunteered talks per session will be selected from the abstracts submitted to ASBMB topic categories #2000-2408, by the November 13 deadline.

Function and Evolution of Metabolic Networks
Sunday, April 21, 2013, 9:55 am - 12:10 pm
Room 253 "C", Level Two - East
Session Chair Ralph DeBerardinis, UT Southwestern Med Ctr at Dallas

Promiscuous enzymes and serendipitous metabolic pathways
Shelley D. Copley, Univ of Colorado, Boulder

How do microbes control their metabolic operation
Uwe Sauer, ETH Zurich

Reconstruction and evolution of metabolic networks across a phylogenetic tree
Dennis Vitkup, Columbia Univ

Controlling Cellular Communication
Monday, April 22, 2013, 3:45 pm - 6:00 pm
Room 253 "C", Level Two - East
Session Chair Anna K. Mapp, Univ of Michigan

Small molecules, toxins and cell death pathways
Deborah Hung, Broad Inst of MIT and Harvard, Massachusetts General Hospital

Signals from the Surface to Control Cell Fate Decisions
Laura Kiessling, Univ of Wisconsin, Madison

Disrupting Bacterial Communication to Suppress Multidrug Resistant Phenotypes
Christian Melander, North Carolina State Univ

Manipulating Metabolic Networks
Tuesday, April 23, 2013, 9:55 am - 12:10 pm
Room 253 "C", Level Two - East
Session Chair Shelley D. Copley, Univ of Colorado, Boulder

Metabolic Pathway Analysis in Cancer
Ralph DeBerardinis, UT Southwestern Med Ctr at Dallas

Exploiting the synthetic capacity of microbes for the production of novel value-added biochemicals
Kristala L.J. Prather, MIT

Towards a comprehensive understanding of cellular metabolism
Joshua Rabinowitz, Princeton Univ

Assembly and Control of Dynamic Protein Complexes
Wednesday, April 24, 2013, 1:45 pm - 4:00 pm
Room 253 "C", Level Two - East
Session Chair Deborah Hung, Broad Inst of MIT and Harvard, Massachusetts General Hospital

Dynamic complexes of intrinsically disordered proteins and their regulation by post-translational modificaitons
Julie Deborah Forman-Kay, Hospital for Sick Children

Capturing transient transcriptional activator-coactivator complexes with large and small molecules
Anna K. Mapp, Univ of Michigan

Functional interactions of intrinsically disordered proteins in signaling networks
Peter E. Wright, The Scripps Res Inst


Genome Replication and Repair

Theme Organizers
Stephen Bell, MIT and
Lei Li, MD Anderson Cancer Ctr

Three (3) volunteered talks per session will be selected from the abstracts submitted to ASBMB topic categories #2000-2408, by the November 13 deadline.

Coordinating Functions at the Replication Fork
Sunday, April 21, 2013, 3:45 pm - 6:00 pm
Session Chair Stephen Bell, MIT

Chromatin Replication and Epigenome Maintenance
Constance Alabert, Univ of Copenhagen

Mechanism of replication-coupled DNA interstrand cross-link repair
Johannas Walter, Harvard Med Sch

Pif1 helicases: helping replication forks maneuver past replication barriers
Virginia Zakian, Princeton Univ

Mechanism and Control of Replication Initiation
Monday, April 22, 2013, 9:55 am - 12:10 pm
Session Chair Virginia Zakian, Princeton Univ

Forkhead (Fox) transcription factors open a new dimension in understanding the epigenetic control of replication origins in S. cerevisiae
Oscar Aparicio USC

Mechanism of Eukaryotic Helicase Loading and Activation
Stephen Bell, MIT

Controlling genome integrity via post-translational regulation of the eukaryotic replisome
Karim Labib, Univ of Manchester

Activation of DNA Damage Signaling
Tuesday, April 23, 2013, 3:45 pm - 6:00 pm
Session Chair Lei Li, MD Anderson Cancer Ctr

Regulatory ubiquitylation during the response to DNA double-strand breaks
Daniel Durocher, Samuel Lunenfeld Res Inst

Holliday Junction Resolvases: the Good, the Bad and the Ugly
Stephen West, Cancer Research UK

Sensing of DNA breaks by the ATM and ATR checkpoint kinases
Lee Zou, Massachusetts Gen Hosp Cancer Ctr

Mechanisms of Genomic Stability
Wednesday, April 24, 2013, 9:55 am - 12:10 pm
Session Chair KJ Patel, Med Res Council, UK

Genetic Approaches to Cancer
Steve Elledge, Harvard Med Sch

Fanconi anemia protein function
Lei Li, MD Anderson Cancer Ctr

Toxic Metabolism and DNA Repair and Haematopoesis
KJ Patel, Med Res Council, UK



Glycan Regulation of Signaling Pathways

Theme Organizers
Pamela Stanley, Albert Einstein Col of Med and
Lance Wells, Univ of Georgia

Three (3) volunteered talks per session will be selected from the abstracts submitted to ASBMB topic categories #2000-2408, by the November 13 deadline.

O-Mannose Glycans and Muscular Dystrophy
Sunday, April 21, 2013, 9:55 am - 12:10 pm
Session Chair Pamela Stanley, Albert Einstein Col of Med

Dystroglycanopathy Studies Reveal Novel Glycosylation Pathways
Kevin P. Campbell, HHMI, Univ of Iowa

The role of protein O-mannosylation during mouse development
Sabine Strahl, Univ of Heildelberg

The mammalian O-mannosylation pathway: protein substrates, enzymes, and structures
Lance Wells, Univ of Georgia

Glycosyltransferases that Control Cell Growth and Differentiation
Monday, April 22, 2013, 3:45 pm - 6:00 pm
Session Chair Lance Wells, Univ of Georgia

Molecular Regulation of Protein O-glycosylation and Relevance to Disease and Development
Richard Cummings, Emory Univ Sch of Med

Homeostatic control of cell growth and differentiation by Golgi proofreading
Michael Demetriou, UC, Irvine

Roles for Glycans in Mammalian Development and Spermatogenesis
Pamela Stanley, Albert Einstein Col of Med

Roles for Glycans in Notch Signaling
Tuesday, April 23, 2013, 3:45 pm - 6:00 pm
Session Chair Linda Hsieh-Wilson, HHMI, Caltech

Post-transcriptional regulation of Lunatic fringe provides a critical mechanism to control Notch pathway signaling during somitogenesis
Susan E. Cole, Ohio State Univ

Site specific analysis of O-fucose and O-glucose glycans on Notch
Robert Haltiwanger, Stony Brook Univ

Glycan-dependent control of myelopoiesis
John B. Lowe, Genentech, Inc

Regulation of Gene Expression by O-GlcNAc
Wednesday, April 24, 2013, 9:55 am - 12:10 pm
Session Chair Robert Haltiwanger, Stony Brook Univ

O-GlcNAc Signaling Regulates Cancer Metabolism
Linda Hsieh-Wilson, HHMI, Caltech

O-GlcNAc links cancer metabolism to oncogenic signaling
Keith Vosseller, Drexel Univ Col of Med

Strucutral Insights into O-GlcNAc transferase
Suzanne Walker, Harvard Univ

Lipids and Membranes

Theme Organizers
Tobias Baumgart, Univ of Pennsylvania and
Marion Sewer, UCSD

Three (3) volunteered talks per session will be selected from the abstracts submitted to ASBMB topic categories #2000-2408, by the November 13 deadline.

Lipid Signaling in Health and Disease
Sunday, April 21, 2013, 3:45 pm - 6:00 pm
Session Chair Rosalind Coleman, Univ of North Carolina

PtdIns(4)P, the Golgi, & Cancer
Seth Field, UCSD

Regulation of Glucocorticoid Production by Nuclear Lipid Metabolism
Marion B. Sewer, UCSD

Sphingosine-1-phosphate signaling in inflammation & cancer
Sarah Spiegel, VCU Sch of Med

Lipid Membrane Curvature In Membrane Function
Monday, April 22, 2013, 9:55 am - 12:10 pm
Session Chair Jennifer Lippincott-Schwartz, NIH

Separation of time-scales in the functional biophysics of BAR domain proteins.
Tobias Baumgart, Univ of Pennsylvania

Spatiotemporal Control of Endocytosis by Phosphatidylinositol 3,4-Bisphosphate
Volker Haucke, Leibniz Institut für Molekulare Pharmakologie

Exocytic and Endocytic Mechanisms: Discovering a role for membrane curvature and curvature stress
Harvey McMahon, Cambridge Univ

Lipid Trafficking and Sorting
Tuesday, April 23, 2013, 3:45 pm - 6:00 pm
Session Chair Tobias Baumgart, Univ of Pennsylvania

The role of Lipid transfer proteins in membrane trafficking and signal transduction
Sima Lev, Weizmann Inst

Molecular dynamics of endomembrane structure and function
Jennifer Lippincott-Schwartz, NIH

Endocytic membrane traffic and cell signaling
Mark von Zastrow, UCSF

Lipids In Nutrient Metabolism and Metabolic Dysfunction
Wednesday, April 24, 2013, 9:55 am - 12:10 pm
Session Chair Marion B. Sewer, UCSD

Glycerolipid intermediates alter insulin signaling
Rosalind Coleman, Univ of North Carolina

Dietary Fat Composition Modifies Cell Sphingolipid Biosynthesis to Mediate the consequences of obesity.
L. Ashley Cowart, Med Univ of South Carolina

TGR5, bile acids, & the metabolic syndrome
Kristina Schoonjans, Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland

Mechanisms of Gene Transcription and Regulation

Theme Organizers
Stephen Buratowski, Harvard Med Sch and
Geeta Narlikar, UCSF

Three (3) volunteered talks will be selected from the abstracts submitted to ASBMB topic categories #2000-2408, by the November 13 deadline.

Chromatin Remodeling During Transcription
Sunday, April 21, 2013, 9:55 am - 12:10 pm
Session Chair Geeta Narlikar, UCSF

Regulation and specificity of the Chd1 chromatin remodeler
Gregory Bowman, Johns Hopkins Univ

Regulation of ATP-dependent Chromatin Remodeling
Brad Cairns, Univ of Utah

Chromatin assembly and disassembly
Jessica Tyler, UT MD Anderson Cancer Ctr

Transcription Mechanisms
Monday, April 22, 2013, 3:45 pm - 6:00 pm
Session Chair Robert Kingston, Harvard Med Sch

Analysis of RNA polymerase II transcription initiation and elongation complexes
Stephen Buratowski, Harvard Med Sch

Proteomic Analysis of Pol II Preinitiation Complexes: The Roles of Mediator and SAGA
Michael Carey, UCLA

Post-initiation roles for the sigma subunit of bacterial RNA polymerase
Ann Hochschild, Harvard Med Sch

Co-transcriptional Coupling Mechanisms
Tuesday, April 23, 2013, 9:55 am - 12:10 pm
Session Chair Stephen Buratowski, Harvard Med Sch

The role of the Paf1 complex in controlling transcription-coupled histone modifications
Karen M. Arndt, Univ of Pittsburgh

Regulating CTD-Interactions by Ess1-Dependent Prolyl Isomerization
Steven Hanes, SUNY-Upstate Med Univ

Structural and functional studies of mRNA processing and quality control
Liang Tong, Columbia Univ

Repressive Chromatin
Wednesday, April 24, 2013, 1:45 pm - 4:00 pm
Session Chair Jessica Tyler, UT MD Anderson Cancer Ctr

Talk title TBA
Wendy Bickmore, MRC IGMM, Univ of Edinburgh

Epigenetic mechanism: silent nucleosomal structures and non-coding RNAs.
Robert Kingston, Harvard Med Sch

Mechanisms of HP1 heterochromatin assembly
Geeta Narlikar, UCSF

Mechanisms of Signal Transduction

Theme Organizers
Kun-Liang Guan, UCSD and Carol Lange, Univ of Minnesota Masonic Cancer Ctr

Three (3) volunteered talks per session will be selected from the abstracts submitted to ASBMB topic categories #2000-2408, by the November 13 deadline.

Mechanisms of Cell Growth and Autophagy Regulation
Sunday, April 21, 2013, 3:45 pm - 6:00 pm
Session Chair J. Silvio Gutkind, NIDCR, NIH

AMPK and mTOR in nutrient signaling and autophagy regulation
Kun-Liang Guan, UCSD

Formation and maturation of the authophagosome
Noboru Mizushima, Univ of Tokyo

Reconstitution of the Class III Phosphatidylinositol-3-kinase in autophagy
Qing Zhong, UC, Berkeley

Protein Phosphorylation Networks
Monday, April 22, 2013, 9:55 am - 12:10 pm
Session Chair Carol Lange, Univ of Minnesota Masonic Cancer Ctr

Proteomics and the Control of MAP Kinase Dynamics
Natalie Ahn, Univ of Colorado, Boulder

Signaling by the cJun NH2-terminal kinase
Roger J. Davis, HHMI/Univ of Massachusetts Med Sch

Novel secreted protein kinases
Jack E. Dixon, Howard Hughes Med Inst (HHMI)

G-proteins in Cellular Regulation
Tuesday, April 23, 2013, 3:45 pm - 6:00 pm
Session Chair Kun-Liang Guan, UCSD

RhoA and Rap1 mediate GPCR crosstalk to integrins and cell growth
Joan H. Brown, UCSD

Lysophospholipid GPCRs in medical therapeutics and disease mechanisms
Jerold Chun, The Scripps Res Inst

Novel G protein- and GPCR-Regulated Oncogenic Signaling Circuitries
J. Silvio Gutkind, NIDCR, NIH

Mechanisms of Signaling Specificity in Cell Fate: Growth, Proliferation or Death?
Wednesday, April 24, 2013, 9:55 am - 12:10 pm
Session Chair Melanie Cobb, UT Southwestern Med Ctr

mTOR, metabolism and cell growth control
John Blenis, Harvard Med Sch

A Common Docking (CD) Domain in Progesterone Receptor-B Links Rapid Signaling Events to JAK/STAT-dependent Gene Expression Required for Breast Cancer Cell Proliferation
Carol Lange, Univ of Minnesota Masonic Cancer Ctr

ERK1/2 regulation of cell fate in human mammary ductal development
Deborah Ann Lannigan, Vanderbilt Univ


Protein Modification, Trafficking and Degradation

Theme Organizers
Daniel Finley, Harvard Med Sch and
Maurine Linder, Cornell Univ

Three (3) volunteered talks per session will be selected from the abstracts submitted to ASBMB topic categories #2000-2408, by the November 13 deadline.

Ubiquitin and Ubiquitin-Like Modifications
Sunday, April 21, 2013, 9:55 am - 12:10 pm
Session Chair Heran Darwin, NYU

Regulation of the proteasome through ubiquitin chain editing
Daniel Finley, Harvard Med Sch

Protein quality control degradation in the nucleus
Richard Gardner, Univ of Washington Sch of Med

Twists and turns in ubiquitin conjugation cascades
Brenda Schulman, HHMI/St. Jude's Children's Res Hosp

The Multivesicular Body and Endocytosis
Monday, April 22, 2013, 3:45 pm - 6:00 pm
Session Chair Brenda Schulman, HHMI/St. Jude's Children's Res Hosp

ESCRTing receptor down-regulation; Assembly and function of the ESCRT-III complex
Scott Emr, Cornell Univ, Weill Inst for Cell and Molecular Biology

Mechanism of Dynamin-Catalyzed Membrane Fission
Sandra Schmid, UT Southwestern Medical Center

The ESCRT Pathway in HIV Budding and Cell Division
Wes Sundquist, Univ of Utah

Mechanisms of Bacterial Pathogenesis
Tuesday, April 23, 2013, 9:55 am - 12:10 pm
Session Chair Neal M. Alto, UT Southwestern Med Ctr

Probing mechanisms of endomembrane trafficking using bacterial effector molecules
Neal M. Alto, UT Southwestern Med Ctr

Mycobacterium tuberculosis proteasomes, pupylation and pathogenesis
Heran Darwin, NYU

Biochemical dissection of bacterial virulence and macrophage innate immunity
Feng Shao, Nat'l Inst of Biological Sci, Beijing



Proteomics of Post-translational Modifications Workshop
Tuesday, April 23, 2013, 12:30 pm - 2:00 pm
Session Chair Steven P. Gygi, Harvard Med Sch

Phosphorylation analysis by mass spectrometry
Steven P. Gygi, Harvard Med Sch

Wheat from Chaff: Finding Modifications That Matter Most
Neil Kelleher, Northwestern Univ

Chemical Proteomics of Cysteine Modifications
Brent Martin, Univ of Michigan



Regulatory Thiol Modifications
Wednesday, April 24, 2013, 1:45 pm - 4:00 pm
Session Chair Maurine Linder, Cornell Univ

Wednesday, April 24, 2013, 1:45 pm - 4:00 pmSession Chair Maurine Linder, Cornell Univ

Redox Control of Chaperone Function
Ursula Jakob, Univ of Michigan

Mechanism and function of DHHC S-Acyltransferases
Maurine Linder, Cornell Univ

Regulation of signal transduction through redox control of protein tyrosine phosphatase function
Nicholas Tonks, Cold Spring Harbor Lab









RNA Function and Protein Synthesis

Theme Organizers
Rachel Green, Johns Hopkins Univ Sch of Med and
Dan Herschlag, Stanford Univ

Three (3) volunteered talks per session will be selected from the abstracts submitted to ASBMB topic categories #2000-2408, by the November 13 deadline.

How RNA Molecules Behave and Misbehave?
Sunday, April 21, 2013, 3:45 pm - 6:00 pm
Session Chair Dan Herschlag, Stanford Univ

Predictive Understanding of RNA Dynamic Behavior: Bringing Order to Disorder
Hashim Al-Hashimi, Univ of Michigan

'Hidden' states are pervasive in RNA folding: detection and dissection through mutate-and-map experiments
Rhiju Das, Stanford Univ

RNA chaperone activity of DEAD-box 'helicase' proteins
Rick Russell, UT Austin

Making and Using RNA in the Nucleus
Monday, April 22, 2013, 9:55 am - 12:10 pm
Session Chair Jeff Coller, Case Western Reserve Sch of Med

Telomerase holoenzyme assembly
Kathy Collins, UC, Berkeley

Regulation of alternative splicing
Klemens Hertel, UC, Irvine

Mechanisms for regulating splicing through signaling pathways
Kristen Lynch, Univ of Pennsylvania Sch of Med

RNA in the Cytoplasm: Translation and Degradation
Tuesday, April 23, 2013, 9:55 am - 12:10 pm
Session Chair Kristen Lynch, Univ of Pennsylvania Sch of Med

Control of mRNA metabolism by deadenylation
Jeff Coller, Case Western Reserve Sch of Med

mRNA surveillance is driven by translation
Rachel Green, Johns Hopkins Univ Sch of Med

The impact of tRNA amounts on translational fidelity
Tao Pan, Univ of Chicago

Frontiers in RNA Biology
Wednesday, April 24, 2013, 1:45 pm - 4:00 pm
Session Chair Rachel Green, Johns Hopkins Univ Sch of Med

Evolution of RNA Binding Proteins and Their Regulatory Networks
Dan Herschlag, Stanford Univ

CRISPR/Cas, the RNA-based adaptive immune system of prokaryotes
Luciano Marraffini, Rockefeller Univ

Integration of 3'UTR regulatory signals in the worm germline
Sean Ryder, Univ of Massachusetts Med Sch


Triple Negative Breast Cancer

This theme is sponsored by the ASBMB Minority Affairs Committee (MAC).

Theme Organizers
KiTani Parker-Johnson, Xavier University of Louisiana and
Gloria Thomas, Xavier University of Louisiana

Three (3) volunteered talks per scientific session will be selected from the abstracts submitted to ASBMB topic categories #2000-2408, by the November 13 deadline.

Back to the Basics: The Biology of Breast Cancer
Monday, April 22, 2013, 3:45 p.m. - 6:00 p.m.
Session Chair Gloria Thomas, Xavier Univ of Louisiana

Novel targets in advanced breast cancer in African American patients
Stefan Ambs, National Cancer Inst

Exosomal media enhances proliferation, migration, and invasion in triple negative breast cancer
KiTani Parker-Johnson, Xavier Univ of Louisiana

High risk CNIs, race and early stage breast cancer
Patricia Thompson, The Arizona Cancer Ctr

Breast Cancers that Elude Successful Treatments: Triple Negative Breast Cancer
Tuesday, April 23, 2013, 9:55 a.m. - 12:10 p.m.
Session Chair Chindo Hicks, Univ of Mississippi Med Ctr, Arthur Guyton Res Ctr

Molecular classification of triple negative breast cancer
Brian Lehmann, Vanderbilt Univ, Ingram Cancer Ctr

Translational NER and a possible role in triple negative breast cancer
Eddie Reed, Univ of South Alabama

Somatic genetic alterations in lung and breast cancers in different ethnic populations
Matthew Meyerson, Dana-Farber Cancer Inst

Genomics: Successes and Challenges in Identifying Novel Targets in Minority Populations
Wednesday, April 24, 2013, 1:45 p.m. - 4:00 p.m.
Session Chair Eddie Reed, Univ of South Alabama

Integrative Genomics Strategies for Biomarker Discovery in Breast Cancer in Minority Populations
Chindo Hicks, Univ of Mississippi Med Ctr, Arthur Guyton Res Ctr

Ethnogenetic layering to link and predict African American breast cancer patient outcomes with specific African origins
Fatimah L.C. Jackson, UNC - Chapel Hill

Use of GWAS to predict targets associated with cancer in African Americans
Rick Kittles, Univ of Illinois at Chicago

Jobs in Industry
Sunday, April 21, 2013, 9:55 a.m. - 12:10 p.m.
Session Chair Nestor Concha, GlaxoSmithKline

Talk title tba
Nestor Concha, GlaxoSmithKline

Life as a minority scientist in industry and academia
Garry D. Dotson, Univ of Michigan

What are the advantages/disadvantages of postdoctoral training in industry?
Lana Saleh, New England Biolabs

20 Apr - 24 Apr 2013
Boston
United States of America
meeting website