Systems Dynamics in Endocytosis

Endocytosis plays a key role during the physiology and the development of cells. Recent work shows that it plays key roles during signaling, homeostasis and mechanics of the cell. The developments in this field during the last couple of years has been spectacular, including the unraveling of the machineries involved in membrane fission and fusion at the plasma membrane and in multivesicular endosomes, the systems biology of the endocytic pathway (which molecules and cellular systems impinge on endosomal dynamics), the role of endosomal structures during infection in disease and during signaling in development, the deep understanding of endosomal motility, etc.
Once the machineries for endocytosis and endosomal trafficking are discovered, the field became mature to understand the system from a more quantitative perspective. These are developments happening right now. While the importance of Endocytosis in neurobiology, immunology and cellular microbiology has been recognized for some years, the almost ubiquitous importance of Endocytosis for cell signalling and tissue morphogenesis has only emerged very recently, and we are now starting to see the importance of Endocytosis for the prevention of diseases such as cancer. Importantly, not only is Endocytosis research becoming increasingly central in biology, it is making giant leaps because of improved technologies within genetics, model systems, imaging and systems biology. Never before have the challenges and opportunities in endocytosis research been of this magnitude.
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PROGRAMME

DAY 1

Session 1. 09:00-12:30
MACHINERIES IN ENDOCYTOSIS

09:00-10:30 Scottie Robinson: Adaptor Coats in endocytosis
Juan Bonifacino: The Beauty of the Coat
Short talk from submitted abstracts
10:30-11:00 Coffee break
11:00-12:30 Sandy Schmidt: Dynamin and Membrane Fission
Harvey McMahon: Platforms at the Membrane Initiate Endocytosis
Short talk from submitted abstracts
12:30 Lunch


Session 2. 16:00-19:30
MECHANISMS OF ENDOCYTIC CONTROL

16:00-17:30 Andrea Ballabio: Transcriptional Control of the Endosomal Machinery
Jennifer Lippincott-Schwartz: Endosomal Machinery in Cytokinesis
Short talk from submitted abstracts
17:30-18:00 Coffee break
18:00-19:30 Andreas Mayer: Membrane Fusion, Membrane Fission and Osmoadaptation
Rob Parton: Caveolae Formation and Function
Short talk from submitted abstracts
19:30-21:00 POSTER SESSION
21:00 Dinner

DAY 2

Session 3. 09:00-12:30
QUANTITATIVE APPROACHES IN ENDOCYTOSIS

09:00-10:30 Marino Zerial: A Systems Approach to Endocytosis
Lucas Pelkmans: Bayesian Analysis of the Endocytic Machinery
Short talk from submitted abstracts
10:30-11:00 Coffee break
11:00-12:30 Tom Kirchhausen: Dynamics of Clathrin Pit Formation
Jitu Mayor: Theory and Quantitation in Endocytosis
Short talk from submitted abstracts
12:30 Lunch

Session 4. 16:00-19:30
ENDOCYTOSIS IN MODEL SYSTEMS

16:00-17:30 Jiri Frimml: Polarized Endocytosis in Arabidopsis
Pietro de Camilli: Endocytosis in Synaptic Vesicle Recycling
Short talk from submitted abstracts
17:30-18:00 Coffee break
18-19:30 Suzanne Eaton: Endocytosis During Hedgehog Signaling
Frances Brodski: New Insights into Clathrin
Short talk from submitted abstracts
19:30-21:00 POSTER SESSION
21:00 Dinner

DAY 3

Session 5. 09:00-12:30
MULTIVESICULAR ENDOSOMES

09:00-10:30 Jean Gruenberg: MVBs and the EGF Receptor
Jim Hurley: Multivesicular Biogenesis
Short talk from submitted abstracts
10:30-11:00 Coffee break
11:00-12:30 Scott Emr: MVBs in Yeast
Harald Stenmark: The Machinery for MVB Formation
Short talk from submitted abstracts
12:30 Lunch

Session 6. 16:00-19:30
INFECTION AND TOXINS

16:00-17:30 Gisou van der Goot: Endocytosis and the Anthrax Toxin
TBA
Short talk from submitted abstracts
17:30-18:00 Coffee break
18:00-19:30 Gillian Griffiths: Endosomal Sorting at the Immunological Synapse
Ludger Johannes: Toxins and Unconventional Endocytosis
Short talk from submitted abstracts
19:30-21:00 POSTER SESSION
21:00 Dinner

DAY 4
Session 7. 09:00-12:30
UBIQUITIN AND SYSTEMS OF ENDOCYTOSIS

09:00-10:30 Jack Neefjes: Endosomes and MHC Class II Antigen Presentation
Sergio Grinstein: Ion Transport and pH in the Endosomal System
Short talk from submitted abstracts
10:30-11:00 Coffee break
11:00-12:30 Pier Paolo di Fiore: Endocytosis and Ubiquitination in EGF Signaling
Aurelien Roux: Mechanisms of Membrane Fission
Short talk from submitted abstracts
12:30 Lunch
14:00-18:00 Excursion.
19:00-21:00 POSTER SESSION
21:00 CONFERENCE DINNER

DAY 5
DEPARTURE

29 Sep - 4 Oct 2013
Villars
Switzerland
meeting website