23rd Wilhelm Bernhard Workshop on the Cell Nucleus

Session titles
A. Nuclear structure and dynamics
B. Chromatin structure and its regulation
C. Nucleolus, ribosome biogenesis; nuclear bodies
D. Nuclear envelope; nuclear transport processes
E. Gene expression: Transcriptional and posttranscriptional processes
F. DNA replication and repair
G. Plant nuclei and chromatin
H. Nuclear structures as therapeutical targets
+ show speakers and program
Aug. 19:
- 14:00: arrival
14:00 - 18:00: registration
18:00 - 18:15: conference opening
18:15 - 19:15: Wilhelm Bernhard Medal Lecture 2013
19:30 - 22:00: welcome reception in the Hall of the Life Sciences Building

Aug. 20:
08:30 - 12:30: session A/1: Nuclear structure and dynamics
12:30 - 14:00: lunch, poster viewing
14:00 - 18:00: session A/2: Nuclear structure and dynamics
18:00 - 19:00: dinner
Evening: free program, cultural and touristic events of the Debrecen Flower Carnival 2013

Aug. 21:
08:30 - 12:00: session B/1: Chromatin structure and its regulation
12:00 - 13:00: lunch
13:00 - 15:00: session B/2: Chromatin structure and its regulation
15:00 - 15:00: excursion to the "Puszta"; dinner outdoors

Aug. 22:
08:30 - 12:30: session C: Nucleolus, ribosome biogenesis; nuclear bodies
12:30 - 14:00: lunch, poster viewing
14:00 - 16:00: session D: Nuclear envelope; nuclear transport processes
18:00 - 15:00: excursion to Tokaj, sight-seeing; visit to a vine cellar, vine tasting, dinner*
*alternatively, depending on how tight the scientific schedule is going to be: cultural program

Aug. 23:
08:30 - 12:30: session E: Gene expression: Transcriptional and posttranscriptional processes and F: DNA replication and repair
12:30 - 14:00: lunch, poster viewing
14:00 - 18:00: session G: Plant nuclei and chromatin and H: Nuclear structures as therapeutical targets
19:00 - 15:00: Farewell party in the Assembly Hall of the old university building

Aug. 24:
departure
Additional social program:
Sightseeing in Debrecen: visit to the Reformed College of Debrecen, founded in 1538, and the Great Church.
Visit to the thermal bath of Debrecen.

Speakers:
Wilhelm Bernhard Medal Lecture
Tom Misteli (Bethesda, USA)

A. Nuclear structure and dynamics

Ronald Hancock (Québec, Canada)
"New models of the nucleus and chromosomes"

Steven Kosak (Chicago, USA)
"Self-Organization of the Human Genome"

Sergey Razin (Moscow, Russia)
"The role of eukaryotic genome spatial organization in regulation of transcription"

Roel van Driel (Amsterdam, The Netherlands)
"Systems biology of in vivo assembly of chromatin-associated complexes"

Roel van Driel (Amsterdam, The Netherlands)
on large-scale chromatin folding and function

Peter Fraser (Cambridge, UK)
"Three dimensional path of the genome in the nucleus"

Pavel Hozak (Prague, Czech Republic)
"Involvement of nuclear phospholipids in nuclear structure and functions"

Masahiko Harata (Sendai, Japan)
"Actin family proteins involved in the functional organization of the nucleus"

Peter Hemmerich (Jena, Germany)
"The changing nuclear landscape during cellular ageing"

Juan M Vaquerizas (Cambridge, UK)
"Computational approaches to study chromatin organisation"

William Garrard (Dallas, USA)
on: relationships between nuclear organization and gene expression

B. Chromatin structure and its regulation

EMBO lecture:
Geneviéve Almouzni (Paris, France)
"Chromatin assembly and its variation from the basic unit to nuclear domains."

EMBO Young Investigator lecture:
Anja Groth (Copenhagen, Denmark)
"Chromatin replication, histone dynamics and epigenome stability."

David P. Bazett-Jones (Toronto, Canada)
on: Electron spectroscopic imaging

Lynn Megeney (Ottawa, Canada)
on: Cell fate determination and chromatin structure

Paul Knoepfler (Davis, CA)
"Histone variant H3.3 function in dynamic chromatin"

Nikolajs Sjakste (Riga, Latvia)
"Enzymatic activities of proteins tightly bound to DNA"

Ivan Raska (Prague, Czech Republic)
on: PcG proteins/molecular crowding

Alexander Sirotkin (Nitra, Slovakia)
"The role of transcription factors in control of ovarian functions"

C. Nucleolus, ribosome biogenesis; nuclear bodies

Thoru Pederson (Worcester, USA)
"More Surprises from the Nucleolus"

Marion Schmidt-Zachman (Heidelberg, Germany)
"Nucleolar demethylases NO52 and NO66: important players in the development of hematological malignancies"

Ivan Raska (Prague, Czech Republic)
on: rRNA processing

D. Nuclear envelope; nuclear transport processes

Harald Herrmann (Heidelber, Germany)
"Assembly and sorting of lamins"

Yosef Gruenbaum (Jerusalem, Israel)
"The nuclear lamina in health and disease"

Elisabeth McNally (Chicago, USA)
"The LINC complex in nuclear function"

E. Gene expression: Transcriptional and posttranscriptional processes

Piotr Widlak (Gliwice, Poland)
"Co-regulation of the NF-kappaB signaling pathway by Heat Shock Factor 1"

Frances Fuller-Pace (Dundee, United Kingdom)
"The multifunctional RNA helicase p68: roles in cancer development"

Karla Neugebauer (Dresden, Germany)
on: transcription, RNA processing

Giovanni Capranico (Bologna, Italy)
"Topoisomerase functions and epigenetic regulation of gene expression"

Fred Dick (London, Ontario, Canada)
"Chromatin regulation by the retinoblastoma tumour suppressor"

Richard G. Pestell (Philadelphia, USA)
"Cell Cycle Control of genomic signaling"

F. DNA replication and repair

Yves Pommier (Bethesda, USA)
"Repair of topoisomerase-induced DNA damage"

Jorge B. Schvartzman (Madrid, Spain)
"The benefits of intertwining during replication and segregation of chromosomal DNA"

Emanuelle Fabre (Paris, France)
on: chromosome organization and genome stability

G. Plant nuclei and chromatin

Peter Shaw (Norwich, United Kingdom)
"A CDC2-like kinase is responsible for homologue pairing specificity during meiosis in hexaploid wheat"

Christine Foyer (Leed, UK)
"Redox regulation of cell cycle and meristem formation in plants"

Susana Moreno Díaz de la Espina (Madrid, Spain)
"Putative plant homologs of lamins in plants"

H. Nuclear structures as potential therapeutic targets

Ivana de la Serna (Toledo, Ohio, USA)
"SWI/SNF Chromatin Remodeling Enzymes in Melanoma"

Kopitar-Jerala (Ljubljana, Slovenia)
"The role of proteinase inhibitors in the nucleus"

Anna von Mikecz (Duesseldorf, Germany)
"Behavior of nanoparticles in the cell nucleus: analysis of the ubiquitin-proteasome system, nuclear amyloid and neurodegeneration"

Alexander Kotlyar (Tel Aviv, Israel)
"DNA cleavage by silver nanoparticles"

Juergen Bode (Hannover, Germany)
"Site-specific recombinases: from tag-and-target- to tag-and-exchange-based genomic modifications"

Thorsten Schmidt (Tuebingen, Germany)
"The nuclear localization of the affected protein in polyglutamine diseases: Pathological relevance and therapeutic opportunities."

19 Aug - 24 Aug 2013
Debrecen
Hungary
meeting website