THE MULTITASKING ENDOPLASMIC RETICULUM IN HEALTH AND DISEASE

The 2013 symposium "The Multi-tasking Endoplasmic Reticulum in Health and Disease" will begin in the afternoon on Wednesday, May 1 and conclude the evening of May 3rd. The endoplasmic reticulum, the ER, is now recognized as a central control point for compartmental organization of the eukaryotic cell. It manages human health span from the germline/stem cell to the aging population directing renewal of tissues and protecting us throughout life from challenges to physiological stress. Beyond managing the folding and degradation of proteins comprising at least one-third of the eukaryotic genome that generate the communication systems that facilitate multicellular organization, it regulates membrane trafficking driving cell specialization during development. It is essential for compartmentalization of the nucleus and the structure of chromatin. It performs specialized functions such as detoxification by the liver and management of the metabolome by the pancreatic Beta-cell. More recently, a flurry of proposed new activities associated with the ER include the regulation of mitochondrial function, peroxisome biogenesis, autophagosome/phagoautosome formation as well as specialized ER domains that link to antigen cross presentation in the immune system, and cross-talk with viral and bacterial pathogens. The apparent old and new multitasking activities of the ER now serve as the catalyst to bring together a diverse pool of investigators to explore in depth and challenge traditional views of ER function that will help define the ER as a heretofore unanticipated central regulator of eukaryotic function from birth to death through its ability to manage and integrate metabolic, biosynthetic and signaling pathways responsible for human health span.
+ show speakers and program
WEDNESDAY, MAY 1
Keynote Lecture, "From Conventional to Non-Conventional: the ER as a Master Regulator of Human Health Span?"
Presented by: Bill Balch, Scripps Research Institute, La Jolla, USA Opening Network Reception
THURSDAY, MAY 2
SESSION 1:
Multitasking the Folding Problem- from Signaling to Degradation The focus will be on the first step in ER function-generating the protein from conventional to non-conventional.
Speakers: Jonathan Weissman, University of California, San Francisco, USA
3 Volunteer Abstracts will be selected
SESSION 2:
Cross-Talk Between the ER and Mitochondria in Health and Disease. The focus will be to review in depth the increasing awareness of the connectivity of the ER with mitochondria and implications for biological integration of endomembrane systems. Speakers: Gia Voeltz, University of Colorado, Boulder, Colorado, USA
3 Volunteer Abstracts will be selected
SESSION 3: The ER in Generating Organelle Sub Specialization This session will be broken down into four parts to highlight increasing evidence that the ER has a large number of direct connectivities that play critical role(s) in endomembrane regulation of cell function. Again highlighting the shift from conventional to non-conventional.
Part 1: Managing Post - ER Eukaryotic Membrane Biology - the ER-Golgi Interface in Health and Disease
Speakers: Rainer Pepperkok, University of Heidelberg, Heidelberg, Germany; Susan Ferro-Novick, University of California, San Diego, California; and Catherine Rabouille, Hubrecht Institute, Utrecht, Netherlands
2 Volunteer Abstracts will be selected
Part 2: Cleaning House- the Auto/ Phago/ Lysosome System
Speakers: Jennifer Lippincott-Schwartz, Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Development, National Institutes of Health, Bethesda, Maryland, USA
3 Volunteer Abstracts will be selected
Part 3: Dealing with Metabolism - the Peroxisome
Speakers: Rick Rachubinski, University of Alberta, Edmonton, Canada and Yukio Fujiki, Kyushu University, Fukuoka, Japan
2 Volunteer Abstracts will be selected
Part 4: Defending the cell, antigen presentation in the immune system The purpose will be to address the central role of the ER in protecting the host from itself, non-self and the environment - new and emerging topics related to construction and operation of the immune system.
Speakers: Michel Desjardins, University of Montreal, Montreal, Quebec, Canada; Peter Cresswell, Yale University School of Medicine, New Haven, Connecticut, USA; and Sebastian Amigorena, Curie Institute, Paris, France
3 Volunteer Abstracts will be selected
FRIDAY, MAY 3
SESSION 4:
The ER in Pathogenesis- Usurping the ER for the Dark Side This session will explore emerging evidence that the ER is adaptable and be usurped by numerous pathogens to promote pathophysiology through conventional and surprising, non-conventional thoughts about the function of the ER.
Speakers: Luke Wiseman, Scripps Institute, La Jolla, California, USA and Randy Kaufman, The Burnham Institute, San Diego, California, USA
2 Volunteer Abstracts will be selected
SESSION 5:
The ER in Change- from Stemness to Differentiation This session will address the emerging role of the ER in managing development and differentiation to manage complex multi-cellular organismal physiologies.
Speakers: Linda Hendershot, St. Jude's Children Research Hospital, Memphis, Tennessee, USA
2 Volunteer Abstracts will be selected
SESSION 6:
ER Lipid Droplet-Golgi This session will explore the impact of the bi-layer and the lipid environment in not only controlling ER function to function as a central regulator cellular lipid biology.
Speakers: Tommy Nilsson, McGill University, Montreal, Quebec, Canada
2 Volunteer Abstracts will be selected
SESSION 7:
Dealing with the Nuclear Envelope and the Health of Chromatin This session will explore both conventional and non-conventional roles of the ER as the gateway to and from the nucleus.
Speakers: Mike Rout, Rockefeller University, N.Y. Nuclear Pore Architecture, USA and Nada Jabado, McGill University, Montreal, Quebec, Canada
2 Volunteer Abstracts will be selected
SESSION 8:
Closing Banquet Dinner and Lecture "Bringing it all Together and the Future of ER Biology?"
Presented by: John Bergeron, McGill University, Montreal, Quebec, Canada The closing lecture will address whether the non-conventional is the conventional and the new view of the ER in human health span.
SATURDAY, MAY 4
Breakfast & Departures

1 May - 4 May 2013
Warrenton
United States of America
meeting website