Glycoproteins: From structure to disease

This workshop will cover different aspects of glycoproteins, going from molecular structure to disease implications. We also want to discuss new techniques that may be applied to the study of glycoproteins. The workshop will cover the following topics:
Glycation and Glycosylation in disease
Production of glycoproteins
Structural aspects of glycoproteins
Computational studies of glycoproteins
New frontiers in glycoprotein studies
+ show speakers and program
PROGRAMME
WEDNESDAY, 24 APRIL 08:30-11:00 Arrival & Registration
Session I Glycoproteins and disease
09:30 - 09:45 Opening and Welcome
09:45 - 10:15 Carlos Cordeiro (Universidade de Lisboa, Lisbon, PT)
Protein glycation: An unexpected journey
10:15 - 10:45 Aphrodite Kapurniotu (CIPSM. Munich, GE)
Designed mimics of islet amyloid polypeptide as inhibitors of protein aggregation in Alzheimer’s disease and type 2 diabetes
10:45 - 11:15 Coffee Break
11:15 - 11:45 Paul J. Thornalley (University of Warwick, Coventry, UK)
Physiological protein glycation by methylglyoxal - the dicarbonyl proteome
11:45 - 12:15 Selected presentation from participants
12:15 - 13:15 Short Talks by selected participants
13:15 - 14:30 Lunch
Session II Production and characterization of Glycoproteins
14:30 - 15:00 R. Leo Brady (University of Bristol, Bristol, UK)
Expression of cell surface adhesion glycoproteins for structural analysis
15:00 - 15:30 Kelley Moreman (University of Georgia, Athens, USA)
Leveraging glycosylation enzyme expression platforms: new structural insights on mammalian glycosyltransferase and glycosidase specificity
15:30 - 16:00 Andrea Carfi Structural Biology of viral envelope glycoproteins and rational antigen design
16:00 - 16:30 Coffee Break
16:30 - 17:00 ChristineM. Szymansky (University of Alberta, Edmonton, CA)
Understanding bacterial N-linked protein glycosylation
17:00 - 20:00 Palma Guided Tour
THURSDAY, 25 APRIL Session III Structure of glycoproteins I
09:30 - 10:00 Frédéric Allain (ETH, Zurich, Switzerland)
Carbohydrate recognition by lectin at high-resolution using NMR spectroscopy
10:00 - 10:30 Jesús Jiménez Barbero (CSIC, Madrid, SP)
Carbohydrate-protein interactions. A 3D view by using NMR.
10:30 - 11:00 Coffee Break
11:00 - 11:30 Mario Schubert (ETH, Zurich, Switzerland)
Glycans rigidified by a C-H⋅⋅⋅O hydrogen bond are found in a large number of glycoepitopes with biological and medical relevance
11:30 - 12:00 Selected presentation from participants
12:30 - 13:00 Short Talks by selected participants
13:00 - 14:30 Lunch
Session IV Structure of glycoproteins II
14:30 - 15:00 Human Rezaei (INRA, Jouy-en-Joses, FR)
Glycan chains modulate prion protein binding to immobilized metal ions and accessibility to new anti-PrP monoclonal antibodies
15:00 - 15:30 Cameron Neylon (RAL. Didcot, UK)
Cameron's conference
15:30 - 16:00 Selected presentation from participants
16:00 - 18:00 Coffee Break & Poster Sesion
20:30 - 23:00 Dinner
FRIDAY, 26 APRIL Session V Computational approaches to Glycoproteins and New Frontiers
09:30 - 10:00 Yaakov Levy (Weizmann Insitute of Science, Rehovot, Israel)
Folding of Glycoproteins: Biophysical consequences of glycosylation
10:00 - 10:30 Ignacio Tuñón (Universidad de Valencia, Valencia, SP)
Protein Motions and Catalysis
10:30 - 11:00 Coffee Break
11:00 - 11:30 Xavier Fernandez Busquets (CRESIB, Barcelona, SP)
Glycosaminoglycans in Alzheimer and malaria and in the origin of Metazoa
11:30 - 12:00 Selected presentation from participants
12:30 - 13:00 Short Talks by selected participants
13:00 - 14:30 Lunch
Session VI New Frontiers
14:30 - 15:30 Kerensa Broensen (University of Twente, Enschede, Netherlands)
Perspectives of protein glycation for food applications
15:30 - 16:00 Louise Serpell (University of Sussex, Brighton, UK)
Self-assembling amyloidogenic proteins: from structure to toxicity
16:00 - 17:00 Coffee Break & Poster Session
17:30 - 18:00 Short Talks by selected participants
18:00 - 18:30 Closing Remarks

24 Apr - 26 Apr 2013
Palma de Mallorca
Spain
meeting website