Proprotein Processing, Trafficking & Secretion

The 2012 meeting will be the tenth Gordon Conference on this subject, having started in 1994. The 2012 meeting will focus on recent research in the cellular and molecular events in the secretory pathway, including post-translational processing, trafficking and secretion of bioactive peptides and other secretory pathway proteins, as well as the significance of these processes to cellular physiology and human disease. In particular this meeting renews its continuing interest in protein folding events in the endoplasmic reticulum; post-translational processing steps including structural, biochemical, proteomic and cellular analyses of proteolysis and peptide-terminal modifications; intra-Golgi and post-Golgi sorting events including targeting to secretory granules; mechanisms of secretory granule formation and trafficking; and molecular mechanisms of regulated and constitutive secretion. An additional important dimension is on pathologies and diseases whose underlying basis relates to protein processing and/or trafficking (e.g., cancer, diabetes; Alzheimer's; hypercholesterolemia; bacterial toxin activation; viral glycoprotein maturation; and others).

The Conference will bring together investigators at the forefront of their research field and will provide many opportunities for junior scientists to present their work and exchange ideas with leaders in the field. In addition to regular talks, a group of poster presenters will be selected to give short oral presentations. The collegial and inter-disciplinary atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an excellent opportunity for scientists from different disciplines to develop collaborations.

+ show speakers and program
Protein Trafficking and Secretion: Classical and Unconventional Pathways
(Annik Prat / Thomas Braulke / Robert Chow / Janice Mayne)
The Secretory Pathway from ER to Exit - Focus on Proinsulin and Diabetes
(Gary Thomas / Don Steiner / Bill Balch / Chris Rhodes / Joshua Zimmerberg / Peter Arvan / Michele Solimena)
New Developments in Proprotein Processing: PCs and Beyond
(Richard Mains / Iris Lindberg / Lakshmi Devi / Betty Eipper)
Imaging Techniques to Study Protein Trafficking and Secretion
(Ron Holz, Daniel Constam / Jennifer Lippincott-Schwartz / Tom F. Martin / Arun Anantharam / Ed Stuenkel / Daniel Mesnard)
Carboxypeptidases in Peptide Processing and Disease
(Y. Peng Loh / Peter Lyons / William Wetsel / Rina Rosin-Arbesfeld / Yong Cheng)
Protein Trafficking and Signaling
(Jan Christian, Yanzhuang Wang / Scott Emr / Christof Niehrs / Loydie Jerome-Majewska / Mihaela Serpe)
Hot Topics in Proprotein Processing, Trafficking, and Secretion
(John Creemers)
Genetics and the Secretory Pathway
(Bob Fuller, Paul Taghert / John Creemers / Michael Blackman / Deborah Andrews / Michael Nonet / Jason Mills)
Proprotein Processing, Trafficking and Secretion in Disease
(An Zhou / Nabil Seidah / Robert Day / Majid Khatib)

15 Jul - 20 Jul 2012
New london
United States of America
meeting website