Ubiquitin and autophagy

Ubiquitin and ubiquitin-like modifiers regulate myriads of cellular processes. In this meeting, we aim to bring together leading researchers from the fields of ubiquitin signaling as well as autophagy, a process that depends on the ubiquitin-like proteins Atg8 and Atg12. It is now clear that many mechanistic aspects and signaling concepts of ubiquitin attachment, recognition and hydrolysis are shared in the autophagy system. More importantly, significant cross-talk exists, as ubiquitination plays a central role in determining cargo for autophagosomal processing. The talks will highlight the most recent developments in the ubiquitin and autophagy arenas, and should stimulate many discussions about where and how the two fields can learn from each other.

• Ubiquitin modification - conjugation, recognition and hydrolysis
• Ubiquitin and Ubiquitin-like modifiers in selective autophagy
• Spatio-temporal regulation of ubiquitination and autophagy events
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Invited speakers
Confirmed speakers
Ivan Dikic (Goethe University, Germany)
Ubiquitin networks in selective autophagy

Zvulun Elazar (Weizmann Institute of Science, Israel)
Relationship between the proteasome and the autophagic systems

Wade Harper (Harvard Medical School, US)
Proteomic exploration of the autophagy system

Ron Hay (University of Dundee, UK)
RNF4: linking the SUMO and ubiquitin pathways

Stefan Jentsch (Max Planck Institute, Germany)
Specificity in the SUMO pathway

David Komander (Medical Research Council, UK)
Structural and functional insights into a Lys11-specific deubiquitinase

Huib Ovaa (Netherlands Cancer Institute, The Netherlands)
Chemical ubiquitination

Matthias Peter (ETH Zurich, Switzerland)
Mechanisms and regulation of selective autophagy

Felix Randow (Medical Research Council, UK)
Autophagy in host-pathogen interactions

David Rubinsztein (University of Cambridge, UK)
The plasma membrane and autophagy

Brenda Schulman (St Jude Children's Research Hospital, US)
Structural insights into E3 ligases

Titia Sixma (Netherlands Cancer Institute, The Netherlands)
Target specificity in the ubiquitin conjugation system

Sharon Tooze (Cancer Research UK, UK)
Molecular mechanisms of mammalian autophagy

Tamotsu Yoshimori (Osaka University, Japan)
Insights into membrane dynamics in autophagy

26 Jun - 27 Jun 2013
Amsterdam
Netherlands
meeting website