Cellular Biology of Addiction

Drug addiction is the most costly neuropsychiatric disorder faced by our nation. Acute and repeated exposure to drugs produces neuroadaption and long-term memory of the experience, but the cellular and molecular processes involved are only partially understood. The primary objective of the proposed workshop is to provide an intense dialogue of the fundamentals, state-of-the-art advances and major gaps in the cell and molecular biology of drug addiction.Targeted to new or experienced investigators, the workshop will combine formal presentations and informal discussions to convey the merits and excitement of cellular and molecular approaches to drug addiction research. With the advent of genomics and proteomics, an extraordinary opportunity now exists to develop comprehensive models of neuroadaptative processes fundamental to addiction, withdrawal, craving, and relapse to drug use and to brain function, in general. A range of disciplines and topics will be represented, including noninvasive brain imaging to identify drug targets and adaptive processes; neuroadaptative processes at the molecular and cellular level, neural networks and their modulation, the relevance of genotype to susceptibility and drug response; tolerance and adaptation at the cellular level and approaches to exploiting the daunting volume generated by neuroinformatics. This workshop will provide an integrated view of current and novel research on neuroadaptive responses to addiction, foster discussion on collaboration and integration, provide critical information needed to construct a model of addiction as a disease and novel molecular targets for biological treatments. Beyond the plane of scientific endeavor, the information is vital for formulating public policy and for enlightening the public on the neurobiological consequences of drug use and addiction. The workshop is designed to generate interest in this level of analysis, open conduits for collaborations and present novel routes to investigating the neurobiology of addictive drugs.
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speakers: to be anounced

Instructors:
Antonello Bonci, NIDA
Christopher Evans, University of California, Los Angeles
Brigitte Kieffer, IGBMC, France
Rafael Maldonado, Universitat Pompeu Fabra, Spain
Mark Von Zastrow, University of California, San Francisco

6 Aug - 12 Aug 2013
Cold Spring Harbor
United States of America
meeting website