Transglutaminases in Human Disease Processes

Transglutaminases are a family of structurally and functionally related proteins that are widely distributed in all living organisms. There has been a recent surge in findings supporting that dysregulated expression and function of transglutaminases contribute to pathological conditions, such as cancer metastasis, tissue fibrosis, celiac disease, neurodegenerative disorders, and diseases related to defective assembly of the stratum corneum of the skin. The 2nd Gordon Conference on "Transglutaminases in Human Disease Processes" will focus on this rapidly expanding field. The meeting will cover cutting-edge research on the biology of transglutaminases and their role in health and disease processes. Sessions will cover recent advances relating to the following topics:

Transglutaminases in growth, development, and differentiation
Transglutaminases as regulators of cell survival and cell death modalities
Transglutaminases in cancer development and metastasis processes
Transglutaminases and cell signal transduction
Transglutaminases in physiological and pathological inflammation
Transglutaminases in celiac, neurodegeneration, and cardiovascular disease
Transglutaminases-induced matrix remodeling in health and disease
Transglutaminases as therapeutic targets
Transglutaminases as a tool for biotechnology

Major focus of this conference is to bring together an international group of experts and new investigators working in this rapidly expanding field with a goal of presenting and discussing the most recent advances in the field. Each talk will be structured to include ample time for discussion. Discussion will cover key issues of current relevance to the field and the implications of the work for future development of this area. Particular attention will be dedicated to fostering open informal debate among attendees during all the meeting. In particular, this conference is designed to provide an opportunity for young investigators to participate and interact with established experts in the field.

+ show speakers and program
Keynote Presentation: Transglutaminases - The Past and Next Decade
(Davies PJA)
Transglutaminases and Celiac Disease
(Laszlo Fesus / Katri Lindfors / L.J. Meyers / Ludwig Sollid)
Transglutaminases and Neurological Disorders
(Anne-Marie Van Dam / Ray Truant / Nancy Muma / Beisha Tang)
Transglutaminases and Cancer
(Daniel Matei / Richard Cerione / R.J. Ablin / Dong-Sup Lee / Soichi Kojima)
Transglutaminases and Inflammation
(T.S. Johnson / Stephanie Watts / Soo-Youl Kim / B.S. Tang / Barry Fanburg)
Transglutaminases in Bone and Skin Pathology
(Mari Kaartinen / Laszlo Muszbek / Richard Eckert / Aki Ichinose / Louis Tong)
Transglutaminases as Transcription Regulators
(Gail Johnson / Tristan Croll / Kevin D. Brown / Santosh Kumar / Rajiv R. Ratan)
Clinical Applications of Transglutaminases
(Mauro Piacentini / Jeff Keillor / Martin Griffin / Keith M. Rich)
Recent Developments in Transglutaminases
(Paul Birckbichler, Kapil Mehta / short talks to be selected from submitted abstracts)

15 Jul - 20 Jul 2012
Davidson
United States of America
meeting website