Molecular Pharmacology New Opportunities with G-protein Coupled Receptors: From Single Molecules and Signaling Complexes to Physiology and Therapeutic Interventions

The Molecular Pharmacology Gordon Research Conference (GRC) has become a key event gathering scientists from basic, applied and clinical science in G protein coupled receptor (GPCR) research. This field has experienced major discoveries over the last 20 years, bringing or reinforcing new concepts that now apply to many other signaling molecules. The 2013 conference, 24th GRC edition, will emphasize both emerging and rapidly growing areas in the field, from receptor dynamics at molecular level to system-level analysis of receptor function. The 2013 program covers four main areas: i) structural dynamics of receptors and biologically relevant receptor complexes including studies at the single molecule level, ii) ligand-biased signaling in cellulo and in vivo, and novel approaches to physiology with an emphasis on animal models, (iii) novel opportunities for drug development and therapeutics and (iv) orphan and atypical GPCRs, revealing new mode of action of these important signaling proteins. Methodological aspects will include novel physical and computing approaches, the development of innovative biosensors and light-controlled processes, and innovative therapeutic strategies that shed new light on mechanisms of GPCR activation, biology and disease. Traditionally the GCR alternates between US west coast and Italy to encourage the international nature of the conference, and the meeting attracts some of the very best scientists from academic and industrial worlds to discuss major developments in the field. The 2013 conference will be held in Tuscany (Il Ciocco, Italy), and set as to encourage open discussions on latest and also controversial ideas in the field, facilitate collaborative work in areas of translational opportunity, and serve as a highly effective forum at which doctoral students, post-docs and junior scientists share their results and interact with more senior colleagues.
+ show speakers and program
SUNDAY
4:00 pm - 8:00 pm Arrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pm Dinner
7:30 pm - 7:40 pm Welcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pm Novel approaches to physiology
7:40 pm - 7:45 pm Discussion Leader: Joël Bockaert (University of Montpellier - France)
7:45 pm - 8:10 pm Karl Deisseroth (Stanford University Howard Hughes Medical Institute, Stanford CA USA)
"GPCR tools for optogenetic"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:45 pm Brian L. Roth (University of North Carolina at Chapel Hill, Durham, NC USA)
"A non-invasive and generic synthetic biology approach for elucidating GPCR functionality in vivo"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Ehud Isacoff (University of California, Berkeley, CA USA)
"Light-gated glutamate receptors: synaptic transmission and plasticity"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm GPCR in physiology
9:00 am - 9:10 pm Discussion Leader: Marc Caron (Duke University Medical Center, Durham, NC USA)
9:10 am - 9:35 am Giovanni Marsicano (INSERM, Bordeaux, France)
"Type-1 Cannabinoid Receptor Signaling in the Brain: the Where Matters"
9:35 am - 9:45 am Discussion
9:45 am - 10:10 am Stefan Offermanns (Max-Planck-Institute for Heart & Lung Research, Bad Nauheim, Germany)
"Vascular and metabolic regulation through GPCRs"
10:10 am - 10:20 am Discussion
10:20 am - 11:00 am Group Photo / Coffee Break
11:00 am - 11:25 am Stuart Sealfon (Mount Sinai Medical Center, New York, USA)
"GnRH receptor signaling mechanism"
11:25 am - 11:35 am Discussion
11:35 am - 12:00 pm Thomas C. Sudhof (Stanford University, Howard Hughes Medical Institute - Stanford - CA USA)
"Role of Latrophilin in synaptic communication"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm TBA
12:25 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 5:30 pm Poster Session
5:30 pm - 7:30 pm Orphan and atypical GPCRs
5:30 pm - 5:40 pm Discussion Leader: JoAnn Trejo (University of California San Diego, CA USA)
5:40 pm - 6:05 pm George Gaitanaris (Omeros Corporation, Seatle, WA USA)
"GPCR desorphanization"
6:05 pm - 6:15 pm Discussion
6:15 pm - 6:40 pm Kazushige Touhara (University of Tokyo, Tokyo, Japan)
"Chemosensory receptors in insects and vertebrates"
6:40 pm - 6:50 pm Discussion
6:50 pm - 7:15 pm Sarah Assmann (Penn State University, USA)
"Plant GPCRs"
7:15 pm - 7:30 pm Discussion
8:00 pm Dinner
TUESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm GPCR structural dynamics
9:00 am - 9:10 pm Discussion Leader: Paul Insel (University of California San Diego, CA USA) & Brian Kobilka (Beckman Center, Stanford University, CA USA)
9:10 am - 9:55 am Brian Kobilka (Beckman Center, Stanford University, CA USA)
"GPCR complexes: structure and dynamics"
9:55 am - 10:05 am Discussion
10:05 am - 10:45 am Coffee Break
10:45 am - 11:10 am Jonathan A. Javitch (Columbia University, New York, NY USA)
"Single molecule studies"
11:10 am - 11:20 am Discussion
11:20 am - 11:45 am Thomas P. Sakmar (Rockefeller University, New York, NY USA)
"New approaches"
11:45 am - 11:55 am Discussion
11:55 am - 12:20 pm Ron Dror (D.E. Shaw Research, New York, NY USA)
"In silico dynamics"
12:20 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 5:30 pm Poster Session
5:30 pm - 7:30 pm Biased cellular signaling
5:30 pm - 5:40 pm Discussion Leader: Graeme Milligan (University of Glasgow, UK)
5:40 pm - 6:05 pm Charles Chavkin (University of Washington, Seatle, WA USA)
"In vivo biased signaling at kappa opioid receptors"
6:05 pm - 6:15 pm Discussion
6:15 pm - 6:40 pm Bice Chini (CNR Cellular and Molecular Pharmacology - Milan - Italy)
"Ligand biased signaling at cellular level"
6:40 pm - 6:50 pm Discussion
6:50 pm - 7:15 pm Mark Von Zastrow (University of California San Francisco, CA USA)
"GPCR signaling along the endocytic pathway"
7:15 pm - 7:30 pm Discussion
8:00 pm Dinner
WEDNESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm New opportunities for treatment
9:00 am - 9:10 pm Discussion Leader: Alan Smrcka (University of Rochester Medical Center - NY USA)
9:10 am - 9:35 am Martine Smit (Vrije Universiteit, Amsterdam, The Netherlands)
"Nanobodies"
9:35 am - 9:45 am Discussion
9:45 am - 10:10 am Michel Bouvier (Université de Montréal, Canada)
"Biosensors"
10:10 am - 10:20 am Discussion
10:20 am - 11:00 am Coffee Break
11:00 am - 11:25 am Ralf Jockers (Institut Cochin, INSERM, Paris France)
"Exon sequencing"
11:25 am - 11:35 am Discussion
11:35 am - 12:00 pm Gozoh Tsujimoto (Kyoto University, Japan)
"GPR120 and obesity"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm TBA
12:25 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 5:30 pm Poster Session
5:30 pm - 7:30 pm Keynote Lecture
5:30 pm - 5:35 pm Discussion Leader: Joël Bockaert (Institut de Génomique Fonctionnelle, Université de Montpellier, France)
5:35 pm - 6:20 pm Gilbert Vassart (Université Libre de Bruxelles, Belgique)
"LGRs: function, evolution, development, diseases"
6:20 pm - 6:30 pm Discussion
6:30 pm - 7:30 pm TBA
7:30 pm - 8:00 pm Business Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
8:00 pm Dinner
THURSDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Receptor complexes and their dynamics
9:00 am - 9:10 pm Discussion Leader: Martin Lohse (University of Wuerzburg, Germany)
9:10 am - 9:35 am Daniel Choquet (Institut Interdisciplinaire de Neurosciences, CNRS, Bordeaux, France)
"AMPA receptor surface trafficking: a new pharmaceutical target?"
9:35 am - 9:45 am Discussion
9:45 am - 10:10 am Bernd Fakler (Institute of Physiology, University of Freiburg, Germany)
"Proteomics of native GPCR complexosome"
10:10 am - 10:20 am Discussion
10:20 am - 11:00 am Coffee Break
11:00 am - 11:25 am Philippe Marin (Institut de Géomique Fonctionnelle, CNRS, Montpellier France)
"The 5-HT6 Receptor-Associated Complex: Role in Neuronal Differentiation and Cognition"
11:25 am - 11:35 am Discussion
11:35 am - 12:00 pm Anirvan Ghosh (F. Hoffmann-La Roche, Basel, Switzerland)
"Latrophilin and its ligand"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm TBA
12:25 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 5:30 pm Poster Session
5:30 pm - 7:30 pm GPCRs and development
5:30 pm - 5:40 pm Discussion Leader: Thue W. Schwartz (University of Copenhagen, Denmark)
5:40 pm - 6:05 pm Stacey Ogden (St. Jude Children's Research Hospital, Memphis, TN USA)
"Mechanisms of Smoothened Regulation and Signaling"
6:05 pm - 6:15 pm Discussion
6:15 pm - 6:40 pm Alejandro Aballay (Duke University Medical School, Durham, NC USA)
"Role of neuronal GPCR signaling in the control of immune homeostasis and longevity"
6:40 pm - 6:50 pm Discussion
6:50 pm - 7:15 pm Xianhua Piao (Harvard Medical School, Boston, MA USA)
"GPR56 and cortical development"
7:15 pm - 7:30 pm Discussion
8:00 pm Dinner
FRIDAY
7:30 am - 8:30 am Breakfast
9:00 am Departure

28 Apr - 3 May 2013
Barga
Italy
meeting website