Cell Biology of Megakaryocytes & Platelets

The Gordon Research Conference (GRC) on the Cell Biology of Megakaryocytes and Platelets is the premier scientific meeting focused on the biology of megakaryocytes and the platelets that arise from them. This will be the 5th biennial meeting that was first organized by Steve Watson and Jon Frampton in 2005 to bring together two groups of scientists with complimentary goals and interests.

Our meeting will begin with processes governing megakaryopoiesis and thrombopoiesis, including from inducible pluripotent and embryonic stem cells, moving to novel computational and screening methods to study theses processes, transitioning to the cell biology of these cells in the context of the cytoskeleton, and then to newly identified signaling, inflammatory and immune functions in megakaryocytes and platelets. This plan then leads smoothly to a session centered on discoveries related to megakaryocyte and platelet pathology. In addition, there is a whole session devoted to presentations of Hot Topics, selected form submitted abstracts. The sessions cover within the same cluster processes that govern megakaryocyte and platelet development and function, thus, allowing convergence of two audiences with overlapping interests, further increasing exchange of perspectives. The translational potential is illustrated in a new session titled: From Bench to Bed Side, and talks, such as on novel therapeutic options for thrombocytosis associated with myeloproliferative neoplasm. Lastly, the program will include, for the first time, a session titled: Breaking Paradigms in Megakaryocyte and Platelet Biology, thus providing opportunities to learn about, and discuss new paradigms that challenge older concepts in the field. Keynote speakers at the end of the conference, Drs. Kenneth Kaushansky and Denisa Wagner, will further discuss ongoing challenges and new findings and perspectives.

This GRC is tied in with a two-day Gordon Research Seminar (GRS) for trainees interested in this field and will give them the opportunity to present their research as well as gain insights from senior academic and industry investigators in this area. A Keynote talk will focus on a historical overview of discovery in megakaryocyte/platelet biology. Abstracts submitted by trainees will be scored by a panel, and selected for oral presentations, of which some will also present under Hot Topics in the GRC. Round table discussions with investigators will provide mentoring related to careers in academia and in pharmaceutical companies.
+ show speakers and program
SUNDAY
4:00 pm - 8:00 pm Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pm Dinner
7:30 pm - 7:40 pm Welcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pm Induced Pluripotent Stem Cells and Embryonic Stem Cells towards Megakaryopoiesis and Thrombopoiesis
7:40 pm - 7:45 pm Discussion Leader: Andrew Leavitt (University of California San Francisco)
7:45 pm - 8:10 pm Koji Eto (Kyoto University)
"Self-replicating megakaryocyte progenitors from human induced pluripotent stem cells and embryonic stem cell"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:45 pm George Murphy (Boston University)
"Pluripotent stem cell modeling of normal and abnormal megakaryocyte development"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Mortimer Poncz (University of Pennsylvania)
"Induced pluripotent stem cells and inherited platelet disorders"
9:20 pm - 9:30 pm Discussion
9:30 pm Refreshments
MONDAY
7:30 am - 8:30 am Breakfast
8:30 am Group Photo
9:00 am - 12:30 pm Screening and Computational Approaches to Decoding Megakaryopoiesis and Thrombopoiesis
9:00 am - 9:05 am Discussion Leader: Willem H. Ouwehand (University of Cambridge, UK)
9:05 am - 9:30 am Paul Bray (Jefferson College)
"Master MiRs that regulate megakaryocyte and platelet development"
9:30 am - 9:45 am Discussion
9:45 am - 10:10 am Jun Lu (Yale University)
"A screen for novel micro RNAs in control of megakaryopoiesis and thrombopoiesis"
10:10 am - 10:25 am Discussion
10:25 am - 11:05 am Coffee Break
11:05 am - 11:30 am Ana Cvejic (University of Cambridge, UK)
"Functional Genomic screen of identified GWAS hits towards understanding megakaryopoiesis"
11:30 am - 11:45 am Discussion
11:45 am - 12:10 pm Yoram Groner (The Weizmann Institute of Science)
"Genome-wide and functional studies of Runx-1 and its partners in leading megakaryopoiesis"
12:10 pm - 12:25 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session I
6:00 pm Dinner
7:30 pm - 9:30 pm Cell Biologists New Views of the Cytoskeleton in Megakaryocyte and Platelet Biology
7:30 pm - 7:35 pm Discussion Leader: Diane Krause (Yale University)
7:35 pm - 8:00 pm Hana Raslova (INSERM, France)
"RUNX1 control of cytoskeletal components and megakaryocyte ploidy"
8:00 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Owen McCarty (Oregon Health Science University)
"Regulation of the Rac axis in platelets"
8:40 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Joseph Italiano (Harvard Medical School)
"New cytoskeletal mechanisms that power platelet production"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Common and Distinct Signaling in Megakaryocyte and Platelet Biology
9:00 am - 9:05 am Discussion Leader: Lawrence (Skip) Brass (University of Pennsylvania)
9:05 am - 9:30 am Mark Ginsberg (University of California San Diego)
"New Insights on regulation of platelet adhesive signaling"
9:30 am - 9:45 am Discussion
9:45 am - 10:10 am Peter Newman (Blood Center of Wisconsin)
"Integrin/ITAM connections in platelets"
10:10 am - 10:25 am Discussion
10:25 am - 10:55 am Coffee Break
10:55 am - 11:20 am Susan Smyth (The Gill Heart Institute)
"Lipid signaling and platelet function"
11:20 am - 11:35 am Discussion
11:35 am - 12:00 pm Sidney Whiteheart (University of Kentucky)
"New signals to platelet secretion"
12:00 pm - 12:15 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session II
6:00 pm Dinner
7:30 pm - 9:30 pm Breaking Paradigms in Megakaryocyte and Platelet Biology
7:30 pm - 7:35 pm Discussion Leader: Steve Watson (University of Birmingham)
7:35 pm - 8:00 pm Yumiko Matsubara (Keio University, Japan)
"Generation of megakaryocytes and platelets from adult fat, non-hematopoietic cells"
8:00 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Andy Weyrich (University of Utah)
"Platelets do divide"
8:40 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Robert Flaumenhaft (Harvard Medical School)
"New 'secretes' about platelet granules"
9:20 pm - 9:30 pm Discussion
9:30 pm Refreshments
WEDNESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Platelets and Megakaryocytes as Inflammatory and Immune Cells
9:00 am - 9:05 am Discussion Leader: Jane Freedman (University of Massachusetts)
9:05 am - 9:30 am Craig Morrel (University of Rochester)
"Platelet and T cell interaction"
9:30 am - 9:45 am Discussion
9:45 am - 10:10 am Scott Crist (Purdue University)
"Platelets and megakaryocytes as inflammatory and immune cells"
10:10 am - 10:25 am Discussion
10:25 am - 10:55 am Coffee Break
10:55 am - 11:20 am Jane Freedman (University of Massachusetts)
"Innate immunity and platelet function"
11:20 am - 11:35 am Discussion
11:35 am - 12:00 pm Thomas McIntyre (Cleveland Clinic)
"Watching platelets and their pro-inflammatory IL-1b-rich microparticles"
12:00 pm - 12:15 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session III
6:00 pm Dinner
7:00 pm - 7:30 pm Business Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pm Hot Topics
Discussion Leader: Leslie Parise (University of North Carolina at Chapel Hill)
7:30 pm - 7:40 pm TBA
7:40 pm - 7:45 pm Discussion
7:45 pm - 7:55 pm TBA
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:10 pm TBA
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:25 pm TBA
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:40 pm TBA
8:40 pm - 8:45 pm Discussion
8:45 pm - 8:55 pm TBA
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:10 pm TBA
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm TBA
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Megakaryocytes and Platelets: from Bench to Bed-Side
9:00 am - 9:05 am Discussion Leader: John Crispino (Northwestern University)
9:05 am - 9:30 am Gerd Blobel (University of Philadelphia)
"Molecular mechanisms of thrombocytopenia involving GATA1 mutations"
9:30 am - 9:45 am Discussion
9:45 am - 10:10 am Graham Molineux (Amgen)
"Romiplostim for the treatment of thrombocytopenia: Development and physiology"
10:10 am - 10:25 am Discussion
10:25 am - 10:55 am Coffee Break
10:55 am - 11:20 am Ross Levine (Memorial Sloan Kettering Cancer Center)
"Jak mutations and megakarocyte-induced myelofibrosis"
11:20 am - 11:35 am Discussion
11:35 am - 12:00 pm Ronald Hoffman (Mount Sinai School of Medicine)
"Novel therapeutic options for thrombocytosis associated with myeloproliferative neoplasms"
12:00 pm - 12:15 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session IV
6:00 pm Dinner
7:30 pm - 9:30 pm Keynote Talks: Megakaryopoiesis Thrombopoiesis and Thrombosis: Now and Tomorrow
7:30 pm - 7:35 pm Discussion Leader: Kenneth Kaushansky (Stony Brook University)
7:35 pm - 8:00 pm Denisa Wagner (Harvard Medical School)
"New insight into innate immune response and thrombosis: the role of Neutrophile Extracellular Traps"
8:00 pm - 8:15 pm Discussion
8:15 pm - 8:40 pm Kenneth Kaushansky (Stony Brook University)
"Thrombopoietin and megakaryocyte/platelet development: From Enigmatic to Mimetics"
8:40 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm David Schenkein (Agios Pharmaceuticals)
"Emerging approaches to Precision Medicine in Hematology/Oncology"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 am Breakfast
9:00 am Departure

10 Mar - 15 Mar 2013
Galveston
United States of America
meeting website