Glycobiology

The 2013 Glycobiology Gordon Research Conference (GRC) will be held March 3-8 at the Ventura Beach Marriott Hotel in Ventura, California. The Glycobiology GRC is one of the most exciting and important meetings in the field and offers a unique opportunity to both contribute to and keep abreast of the latest developments in our multidisciplinary field in a collegial setting. Carbohydrates harbor biological information and many new glycan functions are rapidly emerging from the studies of tissues and organs of humans and model systems, as well as in the area of microbial glycobiology. These advances are fueled by equally dramatic developments in the structural analysis of glycans and proteins interacting with carbohydrates as well as in analytical technologies. This meeting will focus on the roles of glycans in a variety of living systems and processes, including human physiology and pathology. We expect to bring together an outstanding and diverse group of international scientists working at the forefront of research. Twelve scientific sessions are currently planned to cover diverse areas of the field, including structural glycomics, structural glycobiology of enzymes and receptors, chemical glycobiology, glycobiology of viruses, microbes, and parasites, host-microbe interactions, mechanisms of glycosylation and catabolism, epigenetic regulation, glycan diversity, roles of glycobiology in immunology and cancer, and human genetic disorders and vertebrate pathology. In addition to the approximately 31 invited talks, 21 short talks will be selected from poster abstracts, and six Conference Awards will be given for outstanding abstracts submitted by graduate students and post-docs. For the first time, a Glycobiology Gordon Research Seminar will also be held in advance of the GRC that will foster interactions between graduate students, post-docs and established researchers as mentors. All applicants to both meetings are encouraged to present a poster. The size of the GRC has been increased to 175 participants but, since registration is limited, early application is advised. We encourage participation of researchers new to the glycobiology field, as well as junior investigators, scientists from developing countries, racial/ethnic minorities, and disabled persons. Please join us for what promises to be an exciting and interactive meeting.
+ show speakers and program
SUNDAY
4:00 pm - 8:00 pm Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pm Dinner
7:30 pm - 7:40 pm Welcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pm Glycan diversity: biochemistry, regulation and enzymology
Discussion Leader: Robert Haltiwanger (Stonybrook University)
7:40 pm - 8:04 pm Jeff Esko (U California, San Diego)
"Understanding glycan diversity"
8:04 pm - 8:11 pm Discussion
8:11 pm - 8:35 pm Henrik Clausen (U Copenhagen)
"Functional glycomics using Zinc Finger nuclease engineered human cell lines"
8:35 pm - 8:42 pm Discussion
8:42 pm - 9:06 pm Steve Withers (U British Columbia)
"Chemistry and glycobiology: a rewarding relationship"
9:06 pm - 9:13 pm Discussion
9:13 pm - 9:23 pm TBA
9:23 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Glycosylation and Quality Control
Discussion Leaders: Reid Gilmore (U Mass Amherst) and Karen Colley (U Ill Collge of Med)
9:00 am - 9:05 am Introduction: Reid Gilmore (U Mass Amherst) and Karen Colley (U Ill Collge of Med)
9:05 am - 9:28 am Reid Gilmore (U Mass Med School)
"The role of oligosaccharyltransferase isoforms in mammalian cells"
9:28 am - 9:35 am Discussion
9:35 am - 9:58 am Stuart Moore (INSERM, Paris)
"Glycosylation and quality control: a view from the trash can"
9:58 am - 10:05 am Discussion
10:05 am - 10:35 am Group Photo / Coffee Break
10:35 am - 10:45 am TBA
10:45 am - 10:50 am Discussion
10:50 am - 12:30 pm Glycomics
Discussion Leader: Stuart Haslam (Imperial College)
10:50 am - 10:55 am Introduction: Stuart Haslam (Imperial College)
10:55 am - 11:18 am Carlito Lebrilla (U California, Davis)
"Rapid throughput Glycome and Glycoproteome analysis and its implications to Glycobiology"
11:18 am - 11:25 am Discussion
11:25 am - 11:48 am Kay-Hooi Khoo (Academia Sinica)
"Sulfoglycomics: Technical development and applications to immune cells"
11:48 am - 11:55 am Discussion
11:55 am - 12:05 pm TBA
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:20 pm TBA
12:20 pm - 12:25 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm Structure and Biochemistry
Discussion Leader: Steve Withers (U British Columbia)
7:30 pm - 7:32 pm Introduction: Steve Withers (U British Columbia)
7:35 pm - 7:55 pm Koichi Kato (National Institutes of Natural Sciences, Okazaki)
"Molecular and structural basis for N-glycan-dependent determination of glycoprotein fates in cells"
7:55 pm - 8:01 pm Discussion
8:01 pm - 8:24 pm Kaspar Locher (ETH, Zurich)
"Structure and reaction mechanism of bacterial oligosaccharyltransferase"
8:24 pm - 8:30 pm Discussion
8:30 pm - 8:53 pm Karen Colley (U Ill Coll of Medicine)
"Structural basis for protein-specific polysialylation"
8:53 pm - 8:59 pm Discussion
8:59 pm - 9:09 pm TBA
9:09 pm - 9:14 pm Discussion
9:14 pm - 9:24 pm TBA
9:24 pm - 9:29 pm Discussion
TUESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Chemistry
Discussion Leader: Geert-Jan Boons (U Georgia)
9:00 am - 9:05 am Introduction: Geert-Jan Boons (U Georgia)
9:05 am - 9:28 am Carolyn Bertozzi (U California, Berkeley)
"Imaging glycans in microbes"
9:28 am - 9:35 am Discussion
9:35 am - 9:58 am Sabine Flitsch (Univ of Manchester)
"Investigation of glycoenzyme activity using glycoarrays"
9:58 am - 10:05 am Discussion
10:05 am - 10:35 am Coffee Break
10:35 am - 10:45 am TBA
10:45 am - 10:50 am Discussion
10:50 am - 12:30 pm Glycobiology of Viruses
Discussion Leader: James Paulson (Scripps Res Inst)
10:50 am - 10:55 am Introduction: James Paulson (Scripps Res Inst)
10:55 am - 11:18 am Thierry Hennet (University of Zurich)
"Giant virus glycosylation"
11:18 am - 11:25 am Discussion
11:25 am - 11:48 am Yoshihiro Kawaoka (University of Tokyo, U Wisconsin, Madison)
"Pandemic influenza"
11:48 am - 11:55 am Discussion
11:55 am - 12:05 pm TBA
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:20 pm TBA
12:20 pm - 12:25 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm Parasite & Microbial Glycobiology
Discussion Leader: Chris West (U Oklahoma Coll of Med)
7:30 pm - 7:32 pm Introduction: Chris West (U Oklahoma Coll of Med)
7:35 pm - 7:55 pm Michael Ferguson (University of Dundee)
"Sugar nucleotide metabolism in Trypanosoma brucei"
7:55 pm - 8:01 pm Discussion
8:01 pm - 8:24 pm Sonja-Varena Albers (Max Planck Institute)
"N-glycosylation in crenarchaea"
8:24 pm - 8:30 pm Discussion
8:30 pm - 8:53 pm Tamara Doering (Washington U Med Sch)
"Polysaccharide capsule synthesis in the pathogenic yeast Cryptococcus neoformans"
8:53 pm - 8:59 pm Discussion
8:59 pm - 9:09 pm TBA
9:09 pm - 9:14 pm Discussion
9:14 pm - 9:24 pm TBA
9:24 pm - 9:29 pm Discussion
WEDNESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Glycoconjugate biosynthesis and catabolism
Discussion Leader: Jeff Esko (U California, San Diego)
9:00 am - 9:05 am Introduction: Jeff Esko (U California, San Diego)
9:05 am - 9:28 am Robert Linhardt (Rensselaer Polytech Institute)
"Proteoglycan biochemistry, synthesis, and analysis"
9:28 am - 9:35 am Discussion
9:35 am - 9:58 am Harry Brumer (Univ of British Columbia)
"CAZymology of the human gut microbiome"
9:58 am - 10:05 am Discussion
10:05 am - 10:35 am Coffee Break
10:35 am - 10:45 am TBA
10:45 am - 10:50 am Discussion
10:50 am - 12:30 pm Glycoconjugate biosynthesis and catabolism
Discussion Leader: Gerald Hart (Johns Hopkins Med Sch)
10:50 am - 10:55 am Introduction: Gerald Hart (Johns Hopkins Med Sch)
10:55 am - 11:18 am Kelth Vosseller (Drexel College of Medicine)
"O-GlcNAc signaling as metabolic sensor; implications in disease"
11:18 am - 11:25 am Discussion
11:25 am - 11:48 am Tetsuya Okajima (Nagoya Univ School of Medicine)
"Biochemical and biological analysis of O-GlcNAc modification of extracellular proteins"
11:48 am - 11:55 am Discussion
11:55 am - 12:05 pm TBA
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:20 pm TBA
12:20 pm - 12:25 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:00 pm - 7:30 pm Business Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pm Immunology and Cancer
Discussion Leader: Michael Pierce (U Georgia)
7:30 pm - 7:32 pm Introduction: Michael Pierce (U Georgia)
7:35 pm - 7:55 pm Richard Cummings (Emory Sch of Med)
"Tn and SialylTn Antigens in Human Cancer: Genetic Regulation and Contributions to Cancer Phenotypes"
7:55 pm - 8:01 pm Discussion
8:01 pm - 8:24 pm Linda Baum (UCLA)
"O-glycans as master switches to regulate leukocyte migration, function and survival"
8:24 pm - 8:30 pm Discussion
8:30 pm - 8:53 pm Dennis Kasper (Harvard)
"Revising our understanding of the role of carbohydrates in immunity"
8:53 pm - 8:59 pm Discussion
8:59 pm - 9:09 pm TBA
9:09 pm - 9:14 pm Discussion
9:14 pm - 9:24 pm TBA
9:24 pm - 9:29 pm Discussion
THURSDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Host-microbe interactions
Discussion Leader: Richard Cummings (Emory Sch Med)
9:00 am - 9:05 am Introduction: Richard Cummings (Emory Sch Med)
9:05 am - 9:28 am Lora Hooper (UT Southwestern)
"Lectin-mediated immune defense of the intestine"
9:28 am - 9:35 am Discussion
9:35 am - 9:58 am Jonathan Hodgkin (Oxford)
"Glycosylation and bacterial infection in the nematode C. elegans"
9:58 am - 10:05 am Discussion
10:05 am - 10:35 am Coffee Break
10:35 am - 10:40 am TBA
10:40 am - 10:45 am Discussion
10:50 am - 12:30 pm Genetic Disorders and Vertebrate Pathology: I
Discussion Leader: Lance Wells (U Georgia) and Hudson Freeze (Sanford Burnham)
10:50 am - 10:55 am Introduction: Lance Wells (U Georgia) and Hudson Freeze (Sanford Burnham)
10:55 am - 11:18 am Gordon Lauc (U of Zagreb)
"Genes affecting N-glycosylation of human proteins show pleiotropy with autoimmune diseases, cancer, diabetes and neuropsychiatric disorders"
11:18 am - 11:25 am Discussion
11:25 am - 11:48 am Peter Roach (Indiana School of Medicine)
"Glycogen Metabolism and Lafora Disease"
11:48 am - 11:55 am Discussion
11:55 am - 12:05 pm TBA
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:20 pm TBA
12:20 pm - 12:25 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm Genetic Disorders and Vertebrate Pathology: II
Discussion Leader: Lance Wells (U Georgia) and Hudson Freeze (Sanford Burnham)
7:30 pm - 7:32 pm Introduction: Lance Wells (U Georgia) and Hudson Freeze (Sanford Burnham)
7:35 pm - 7:55 pm Francois Foulquier (University of Lille)
"Contribution of CDG-II to the understanding of the molecular mechanisms of N-linked protein glycosylation"
7:55 pm - 8:01 pm Discussion
8:01 pm - 8:24 pm Kevin Campbell (U of Iowa Sch of Med)
"Genetics and Glycobiology of Dystroglycanopathies"
8:24 pm - 8:30 pm Discussion
8:30 pm - 8:53 pm Richard Steet (U Georgia)
"Elucidating ML-II Pathogenesis and GlcNAc-1-Phosphotransferase Function Using Zebrafish"
8:53 pm - 8:59 pm Discussion
8:59 pm - 9:09 pm TBA
9:09 pm - 9:14 pm Discussion
9:14 pm - 9:24 pm TBA
9:24 pm - 9:29 pm Discussion
FRIDAY
7:30 am - 8:30 am Breakfast
9:00 am Departure

3 Mar - 8 Mar 2013
Ventura
United States of America
meeting website